Long non‑coding RNAs are novel players in oral inflammatory disorders, potentially premalignant oral epithelial lesions and oral squamous cell carcinoma (Review)

Zhang, Kaiying; Qiu, Wei; Wu, Buling; Fang, Fuchun

doi:10.3892/ijmm.2020.4628

Cited by 13 publications

(12 citation statements)

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“…However, the scarcity in the literature studying lncRNAs in OLP was noticed. Accordingly, the review encouraged researchers to further investigate lncRNAs in these disorders to unveil their role [ 36 ]. At the best of the authors’ knowledge, there is only one study investigating the expression of DQ786243 in OLP [ 24 ], concluding that the expression of DQ786243 was significantly upregulated in the CD4+ cells from the peripheral blood of OLP patients compared with controls.…”

Section: Discussionmentioning

confidence: 99%

Salivary expression of lncRNA DQ786243 and IL-17 in oral lichen planus: case–control study

2022

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Background A growing number of studies has investigated IL-17 in OLP. However, its exact role and interactions are not fully determined. In addition, the literature investigating its salivary expression is limited. The scarcity in the literature studying lncRNAs was noticed, particularly with regards to correlating them with cytokines in OLP. In the current study, the salivary expression of lncRNA DQ786243 and IL-17 was assessed among different forms of OLP. Methods The study included 52 participants in four equal groups: reticular OLP, erythematous OLP, ulcerative OLP, and control group. All eligible OLP patients underwent conventional oral examination, along with basic charting of their demographic data, pain intensity using a visual analogue scale, and clinical evaluation using the Thongprasom et al. scale. The salivary expression of lncRNA DQ786243 and IL-17 was evaluated for all participants using qRT-PCR. Unstimulated whole saliva samples were used. Data were analyzed for statistical significance. Results No statistically significant difference was observed when comparing the mean age and gender distribution of the studied groups. A statistically significant difference was detected when comparing pain and clinical scores in the three OLP forms. The highest expression of both salivary biomarkers was noticed in ulcerative OLP, followed by erythematous OLP and reticular OLP, then the controls, with a significant difference between the studied groups. Upon comparing the salivary expression of DQ786243 in ulcerative and erythematous OLP, no significant difference was detected. No significant difference was detected when comparing salivary expression of IL-17 in erythematous OLP to the other OLP forms. Conclusions The salivary expression of lncRNA DQ786243 and IL-17 was upregulated in OLP compared to healthy individuals. Besides, their expression increased when the severity of OLP was at its highest level in ulcerative OLP. There was a positive correlation between DQ786243 and IL-17. Trial registration The protocol was registered at ClinicalTrials.gov (NCT04503824). The date of registration is 07/08/2020.

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Section: Discussionmentioning

confidence: 99%

Salivary expression of lncRNA DQ786243 and IL-17 in oral lichen planus: case–control study

2022

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“…The expression and abundance of lncRNAs is tissue specific; they have specific cellular localization, and have the ability to alter signaling pathways by interacting with nucleic acids and proteins. They are involved in gene expression regulation at the pre-, post-, and transcriptional level via changes in the chromatin state, and transcriptional activity, splicing, and translation [ 11 , 12 ]. LncRNAs can be subclassified into the groups of very long intergenic RNAs longer than 10 kb, and macroRNAs, which are pathway specific [ 13 ].…”

Section: Non-coding Rna Transcriptomementioning

confidence: 99%

Clinical Perspectives of Non-Coding RNA in Oral Inflammatory Diseases and Neuropathic Pain: A Narrative Review

Roganović

Petrović

2022

IJMS

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Non-coding RNAs (ncRNAs) represent a research hotspot by playing a key role in epigenetic and transcriptional regulation of diverse biological functions and due to their involvement in different diseases, including oral inflammatory diseases. Based on ncRNAs’ suitability for salivary biomarkers and their involvement in neuropathic pain and tissue regeneration signaling pathways, the present narrative review aims to highlight the potential clinical applications of ncRNAs in oral inflammatory diseases, with an emphasis on salivary diagnostics, regenerative dentistry, and precision medicine for neuropathic orofacial pain.

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“…Noncoding RNA (ncRNA), accounting for 90% of the human transcriptome, has been revealed to play a pivotal role in various biological processes via interference with gene expression [ 8 , 9 ]. Emerging evidence has shown that the dysregulated expression of ncRNAs is associated with numerous diseases [ 10 , 11 ]. lncRNAs with a length of more than 200 nucleotides were initially regarded as “transcriptional noise” and nonfunctional [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Comprehensive analysis of the long noncoding RNA-associated competitive endogenous RNA network in the osteogenic differentiation of periodontal ligament stem cells

Lai¹,

Wang

Qiu

et al. 2022

BMC Genomics

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Backgroud The mechanism implicated in the osteogenesis of human periodontal ligament stem cells (PDLSCs) has been investigated for years. Previous genomics data analyses showed that long noncoding RNA (lncRNA), microRNA (miRNA) and messenger RNA (mRNA) have significant expression differences between induced and control human PDLSCs. Competing for endogenous RNAs (ceRNA), as a widely studied mechanism in regenerative medicine, while rarely reported in periodontal regeneration. The key lncRNAs and their ceRNA network might provide new insights into molecular therapies of periodontal regeneration based on PDLSCs. Results Two networks reflecting the relationships among differentially expressed RNAs were constructed. One ceRNA network was composed of 6 upregulated lncRNAs, 280 upregulated mRNAs, and 18 downregulated miRNAs. The other network contained 33 downregulated lncRNAs, 73 downregulated mRNAs, and 5 upregulated miRNAs. Functional analysis revealed that 38 GO terms and 8 pathways related with osteogenesis were enriched. Twenty-four osteogenesis-related gene-centred lncRNA-associated ceRNA networks were successfully constructed. Among these pathways, we highlighted MAPK and TGF-beta pathways that are closely related to osteogenesis. Subsequently, subnetworks potentially linking the GO:0001649 (osteoblast differentiation), MAPK and TGF-beta pathways were constructed. The qRT-PCR validation results were consistent with the microarray analysis. Conclusion We construct a comprehensively identified lncRNA-associated ceRNA network might be involved in the osteogenesis of PDLSCs, which could provide insights into the regulatory mechanisms and treatment targets of periodontal regeneration.

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Long non‑coding RNAs are novel players in oral inflammatory disorders, potentially premalignant oral epithelial lesions and oral squamous cell carcinoma (Review)

Cited by 13 publications

References 100 publications

Salivary expression of lncRNA DQ786243 and IL-17 in oral lichen planus: case–control study

Salivary expression of lncRNA DQ786243 and IL-17 in oral lichen planus: case–control study

Clinical Perspectives of Non-Coding RNA in Oral Inflammatory Diseases and Neuropathic Pain: A Narrative Review

Comprehensive analysis of the long noncoding RNA-associated competitive endogenous RNA network in the osteogenic differentiation of periodontal ligament stem cells

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