Long non‑coding RNA00887 reduces the invasion and metastasis of non‑small cell lung cancer by causing the degradation of miRNAs

Abstract

Long non-coding RNAs (lncRNAs) can act as carcinogenic or cancer suppressive factors during the pathogenesis, invasion and metastasis of non-small cell lung cancer (NSCLC). The current study explored the role of long intergenic non-protein coding RNA 00887 (LINC00887) and competing endogenous RNAs (ceRNAs). It was revealed that LINC00887 interacts with several microRNAs (miRs), which regulates downstream genes such as fibronectin 1, MET proto-oncogene, receptor tyrosine kinase and mothers against decapentaplegic homolog 4, which are associated with the spread of lung cancer. The experimental results also suggested that LINC00887 can stimulate miR-613, miR-206 and miR-1-2 to become competing endogenous RNAs, which may regulate the epithelial-mesenchymal transition of NSCLC cells through the transforming growth factor-â signal transduction pathway, and therefore promote the migration of cells and the acquisition of stem cell characteristics. Therefore, it can be concluded that high levels of LINC00887 can accelerate the malignant transformation ability of NSCLC cells.

<p>miR-613 Suppresses Chemoresistance and Stemness in Triple-Negative Breast Cancer by Targeting FAM83A</p>

“…10 miR-613 has been demonstrated to be downregulated in several types of cancers including renal cell carcinoma, glioma, lung cancer, and cervical cancer, implying that miR-613 may act as a tumor suppressor gene. [11][12][13][14] For instance, miR-613 targeted CDK9 to inhibit proliferation and invasion. 15 It was also reported that downregulation of miR-613 facilitated liver cancer stem cells, indicating that miR-613 was involved in tumor stemness.…”

Long noncoding RNA POU6F2-AS1 regulates lung cancer aggressiveness through sponging miR-34c-5p to modulate KCNJ4 expression

“…In a variety of cancers, lncRNAs are involved in a broad range of molecular mechanisms containing functioning as ceRNAs, scaffolds and signals to regulate the expression of gene (Tsai et al, 2010;Wang K and Chang, 2011). Numerous publications have elaborated that lncRNAs, served as competitive endogenous RNAs (ceRNAs), can directly sponge miRNAs and regulate key genes, thereby modulating the processes of physiological and pathological in human Tian et al, 2019;Zhang Y et al, 2019). Thus, we then screened the possible lncRNAs of miR-34c-5p and KCNJ4 to form a ceRNA mechanism.…”

Linc00887 suppresses tumorigenesis of cervical cancer through regulating the miR-454-3p/FRMD6-Hippo axis

“…For example, lncRNA STXBP5-AS1 inhibited cervical cancer progression by targeting miR-96-5p [23], lncRNA FOXF1 Adjacent Non-Coding Developmental Regulatory RNA (FENDRR) inhibited non-small cell lung cancer progression by targeting miR-76 [24], and lncRNA HAND2 antisense RNA 1 (HAND2-AS1) inhibited colorectal cancer progression by targeting miR-1275 [25]. It was reported that linc00887 inhibited cell invasion in non-small cell lung cancer by causing the degradation of miR-1-2, miR-206 or miR-613 [14]. In our research, we revealed that linc00887 level was downregulated in tumor tissues of patients with cervical cancer or cervical cancer cell lines, compared with epithelial cell line normal tissues or normal epithelial cell line.…”

“…Linc00887 (NR_024480.1), located at chr3q29, has a length of 3021 nucleotides and consists of three exons. Previous studies showed that linc00887 played an anti-cancer role in lung cancer [14]. In addition, it has been reported that linc00887 plays an important role in nasopharyngeal carcinoma, non-small cell lung cancer and renal cell carcinoma [15,16], but the role of linc00887 was largely unknown in cervical cancer.…”