Long non‑coding RNA ZFPM2‑AS1 promotes colorectal cancer progression by sponging miR‑137 to regulate TRIM24

Xiao, Meihua; Liu, Zhi; Yin, Zhihui

doi:10.3892/mmr.2020.11737

Cited by 10 publications

(3 citation statements)

References 29 publications

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“…Only one (C9orf170) of the six lncRNAs met the criteria for expression validation, co-expression analysis, and survival analysis. Emerging evidence suggests that lncRNAs may have critical effects on cancer progression and development [41,42]. However, there are few reports on the effects of C9orf170 on diseases.…”

Section: Discussionmentioning

confidence: 99%

Identification of a novel competing endogenous RNA network linked to the prognosis of prostate cancer

Song

et al. 2023

Preprint

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According to mounting evidence, competing endogenous RNAs (ceRNA) play a significant role in the tumorigenesis and development of cancer. Prostate cancer (PCa) is a common malignancy among men. Nevertheless, reliable indicators for the early diagnosis and prognosis of Pca are still lacking. Therefore, this study aimed to identify competing endogenous RNA networks as novel prognostic predictors of PCa. The Cancer Genome Atlas was used to download the RNA transcriptome and clinical data of 498 Pca and 52 non-Pca tissues. Differentially expressed messenger RNAs (DEmRNAs) were identified using the edgeR package. Kaplan–Meier analysis was used to evaluate the correlation with survival. TargetScan and MiRDB were used to predict potential DRD5‒targeting microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). In addition, StarBase and GEPIA2 were used to validate regulatory and prognostic relationships. DEmRNAs, target miRNAs, and lncRNAs were identified, and a ceRNA network in PCa was constructed. A total of 1,603 Pca-specific differentially expressed genes (767 upregulated and 836 downregulated) were identified. In addition, 3 hub mRNAs, 26 miRNAs,and 2 lncRNAs were identified as a result of stepwise prediction and validation from mRNA to lncRNA. Finally, C9orf170/hsa-miR-153-5p/DRD5 was identified as a prognosis-related network in PCa through further screening. In this study, we constructed a novel ceRNA network in PCa in which each component was prognosis-related.

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Section: Discussionmentioning

confidence: 99%

Identification of a novel competing endogenous RNA network linked to the prognosis of prostate cancer

Song

et al. 2023

Preprint

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“…For example, studies have demonstrated that dysregulation of lncRNA ZFPM2-AS1 is implicated in the initiation and development of a variety of malignant tumors; lncRNA ZFPM2-AS1 is located at the 8q23 region, an aggregate of cancer susceptibility loci, ( Okamoto et al, 2003 ), and can act as an oncogene to promote HCC cell proliferation, invasion, and metastasis. As discovered by Xiao et al, lncRNA ZFPM2-AS1 can promote colorectal cancer progression by sponging miR-137 to regulate TRIM24 ( Xiao et al, 2021 ). Similarly, LUCAT1 also plays a key role in the progression and metastasis of HCC.…”

Section: Discussionmentioning

confidence: 99%

The Pyroptosis-Related Long Noncoding RNA Signature Predicts Prognosis and Indicates Immunotherapeutic Efficiency in Hepatocellular Carcinoma

Wang

Yang

Sun

et al. 2022

Front. Cell Dev. Biol.

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Pyroptosis was recently demonstrated to be an inflammatory form of gasdermin-regulated programmed cell death characterized by cellular lysis and the release of several proinflammatory factors and participates in tumorigenesis. However, the effects of pyroptosis-related long noncoding RNAs (lncRNAs) on hepatocellular carcinoma (HCC) have not yet been completely elucidated. Based on the regression coefficients of ZFPM2-AS1, KDM4A-AS1, LUCAT1, NRAV, CRYZL2P-SEC16B, AL031985.3, SNHG4, AL049840.5, AC008549.1, MKLN1-AS, AC099850.3, and LINC01224, HCC patients were classified into a low- or high-risk group. The high-risk score according to pyroptosis-related lncRNA signature was significantly associated with poor overall survival even after adjusting for age and clinical stage. Receiver operating characteristic curves and principal component analysis further supported the accuracy of the model. Our study revealed that a higher pyroptosis-related lncRNA risk score was significantly associated with tumor staging, pathological grade, and tumor-node-metastasis stages. The nomogram incorporating the pyroptosis-related lncRNA risk score and clinicopathological factors demonstrated good accuracy. Furthermore, we observed distinct tumor microenvironment cell infiltration characteristics between high- and low-risk tumors. Notably, based on the risk model, we found that the risk score is closely related to the expression of immune checkpoint genes, immune subtypes of tumors, and the sensitivity of HCC to chemotherapy drugs and immunotherapy. In conclusion, our novel risk score of pyroptosis-related lncRNA can serve as a promising prognostic biomarker for HCC patients and provide help for HCC patients to guide precision drug treatment and immunotherapy.

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“…In addition, the elevated levels of another lncRNA FOG family member 2 antisense RNA 1 (ZFPM2-AS1) were demonstrated to be correlated with cell proliferation, migration, and invasion in CRC. The ZFPM2-AS1 acts as competing endogenous RNA (ceRNA) and competitively binds with miR-137 and in turn, upregulates the expression of tripartite motifcontaining 24 (TRIM24) which is a downstream target of miR-137 [135]. Previous studies showed that the upregulation of TRIM24 is associated with increased proliferation and inhibition of apoptosis in CRC cells, Moreover, the knockdown of TRIM24 leads to a decrease in the expression of Bcl-2 and a significant increase in the expression of caspase 3 and PARP [136,137].…”

Section: Intrinsic Apoptosis (Mitochondrial Pathway)mentioning

confidence: 99%

Apoptosis evasion via long non-coding RNAs in colorectal cancer

et al. 2022

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Long non-coding RNA (LncRNA) is a novel and diverse class of regulatory transcripts that are frequently dysregulated in numerous tumor types. LncRNAs are involved in a complicated molecular network, regulating gene expression, and modulating diverse cellular activities in different cancers including colorectal cancer (CRC). Evidence indicates that lncRNAs can be used as a potential biomarker for the prognosis and diagnosis of CRC as they are aberrantly expressed in CRC cells. The high expression or silencing of lncRNAs is associated with cell proliferation, invasion, metastasis, chemoresistance and apoptosis in CRC. LncRNAs exert both pro-apoptotic and anti-apoptotic functions in CRC. The expression of some oncogene lncRNAs is upregulated which leads to the inhibition of apoptotic pathways, similarly, the tumor suppressor lncRNAs are downregulated in CRC. In this review, we describe the function and mechanisms of lncRNAs to regulate the expression of genes that are involved directly or indirectly in controlling cellular apoptosis in CRC. Furthermore, we also discussed the different apoptotic pathways in normal cells and the mechanisms by which CRC evade apoptosis.

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Long non‑coding RNA ZFPM2‑AS1 promotes colorectal cancer progression by sponging miR‑137 to regulate TRIM24

Cited by 10 publications

References 29 publications

Identification of a novel competing endogenous RNA network linked to the prognosis of prostate cancer

Identification of a novel competing endogenous RNA network linked to the prognosis of prostate cancer

The Pyroptosis-Related Long Noncoding RNA Signature Predicts Prognosis and Indicates Immunotherapeutic Efficiency in Hepatocellular Carcinoma

Apoptosis evasion via long non-coding RNAs in colorectal cancer

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