Long Non-coding RNA ZFPM2-AS1: A Novel Biomarker in the Pathogenesis of Human Cancers

Sasa, Gabriel B. K.; Chen, Xuan; Lyu, Guoliang; Ding, Xiaohu; Fang, Man

doi:10.1007/s12033-021-00443-3

Cited by 5 publications

(2 citation statements)

References 152 publications

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“…Numerous reports demonstrated that TMPO-AS1 has been revealed to be a key biomarker for evaluating the prognosis of LUAD ( Li et al, 2016 ; Wang et al, 2019 ). ZFPM2-AS1 is an oncogene in gastric cancer ( Sasa et al, 2022 ), but it has also been shown to be involved in the regulation of LUAD cell growth, which can be used as a new potential target for LUAD treatment ( Han et al, 2020 ). As a potential lncRNA in human LUAD, LINC00472 has been proved to be a tumor suppressor, which could suppress LUAD cells viability ( Sui et al, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Construction of a ferroptosis scoring system and identification of LINC01572 as a novel ferroptosis suppressor in lung adenocarcinoma

Wang

Cui

et al. 2023

Front. Pharmacol.

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Background: Ferroptosis is a novel process of programmed cell death driven by excessive lipid peroxidation that is associated with the development of lung adenocarcinoma. N6-methyladenosine (m6a) modification of multiple genes is involved in regulating the ferroptosis process, while the predictive value of N6-methyladenosine- and ferroptosis-associated lncRNA (FMRlncRNA) in the prognosis of patients remains with LUAD remains unknown.Methods: Unsupervised cluster algorithm was applied to generate subcluster in LUAD according to ferroptosis-associated lncRNA. Stepwise Cox analysis and LASSO algorithm were applied to develop a prognostic model. Cellular location was detected by single-cell analysis. Also, we conducted Gene set enrichment analysis (GSEA) enrichment, immune microenvironment and drug sensitivity analysis. In addition, the expression and function of the LINC01572 were investigated by several in vitro experiments including qRT-PCR, cell viability assays and ferroptosis assays.Results: A novel ferroptosis-associated lncRNAs-based molecular subtype containing two subclusters were determined in LUAD. Then, we successfully created a risk model according to five ferroptosis-associated lncRNAs (LINC00472, MBNL1-AS1, LINC01572, ZFPM2-AS1, and TMPO-AS1). Our nominated model had good stability and predictive function. The expression patterns of five ferroptosis-associated lncRNAs were confirmed by polymerase chain reaction (PCR) in LUAD cell lines. Knockdown of LINC01572 significantly inhibited cell viability and induced ferroptosis in LUAD cell lines.Conclusion: Our data provided a risk score system based on ferroptosis-associated lncRNAs with prognostic value in LUAD. Moreover, LINC01572 may serve as a novel ferroptosis suppressor in LUAD.

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Section: Discussionmentioning

confidence: 99%

Construction of a ferroptosis scoring system and identification of LINC01572 as a novel ferroptosis suppressor in lung adenocarcinoma

Wang

Cui

et al. 2023

Front. Pharmacol.

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“…Long non-coding RNAs(lncRNAs) are among non-coding RNAs(ncRNAs), lncRNAs consisting of more than 200 nucleotides are engaged in several biological characteristics such as tumor growth and control of gene expression [5][6][7].With the progress of science and technology, microarray and transcriptome study have helped us find many lncRNAs that are associated with cancer [8,9].while lncRNAs have been reported to have cancer-promoting and cancer-suppressing actions in malignancies(e.g., liver, breast, and colon cancers)among others [6]. Several lncRNAs have been confirmed to as biomarkers for detecting and treating HCC [8] (e.g.,ZFPM2-AS1 [10], LIN0572 [11] and SNHG17 [12]). Furthermore, lncRNAs take on a critical significance for immune cell activation, infiltration, and migration [13].…”

Section: Introductionmentioning

confidence: 99%

Establishment of an endoplasmic reticulum stress-associated lncRNAs model to predict prognosis and immunological characteristics in hepatocellular carcinoma

Shen,

Wu,

Yang

et al. 2023

PLoS ONE

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Background The endoplasmic reticulum stress (ERS) and unfolded protein response (UPR) pathways play an essential role in the pathophysiology of hepatocellular carcinoma (HCC), and activation of the UPR pathway is strongly associated with tumor growth. However, the function of ERS-associated long non-coding RNAs (lncRNAs) in HCC is less recognized. Methods We have used TCGA (The Cancer Genome Atlas) to obtain clinical and transcriptome data for HCC patients and the GSEA (Gene Set Enrichment Analysis) molecular signature database to get the ERS gene. ERS-associated prognostic lncRNA was determined using univariate Cox regression study. Then, least absolute shrinkage and selection operator and multivariate Cox regression study were used to construct ERS-associated lncRNAs risk model. Next, we use Kaplan-Meier (KM) survival study, time-dependent receiver operating characteristic (ROC) curve, univariate and multivariate Cox regression study to validate and evaluate the risk model. GSEA reveals the underlying molecular mechanism of the risk model. In addition, differences in Immune cell Infiltration Study, half-maximal inhibitory concentration (IC50) and immune checkpoints blockade (ICB) treatment between high and low risk groups were analyzed. Results We constructed a risk model consisting of 6 ERS-associated lncRNAS (containingMKLN1-AS, LINC01224, AL590705.3, AC008622.2, AC145207.5, and AC026412.3). The KM survival study showed that the prognosis of HCC patients in low-risk group was better than that in high-risk group. ROC study, univariate and multivariate Cox regression study showed that the risk model had good predictive power for HCC patients. Our verification sample verified the aforesaid findings. GSEA suggests that several tumor- and metabolism-related signaling pathways are associated with risk groups. Simultaneously, we discovered that the risk models may help in the treatment of ICB and the selection of chemotherapeutic drugs. Conclusions In this article, we created an ERS-associated lncRNAs risk model to help prognostic diagnosis and personalized therapy in HCC.

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Gliomas with Downregulation of lncRNA SLC25A21-AS1 Carry a Dismal Prognosis and an Accelerated Progression in Cell Proliferation, Migration and Invasion

Zhu

Zhang

2022

Mol Biotechnol

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Long Non-coding RNA ZFPM2-AS1: A Novel Biomarker in the Pathogenesis of Human Cancers

Cited by 5 publications

References 152 publications

Construction of a ferroptosis scoring system and identification of LINC01572 as a novel ferroptosis suppressor in lung adenocarcinoma

Construction of a ferroptosis scoring system and identification of LINC01572 as a novel ferroptosis suppressor in lung adenocarcinoma

Establishment of an endoplasmic reticulum stress-associated lncRNAs model to predict prognosis and immunological characteristics in hepatocellular carcinoma

Gliomas with Downregulation of lncRNA SLC25A21-AS1 Carry a Dismal Prognosis and an Accelerated Progression in Cell Proliferation, Migration and Invasion

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