Long non-coding RNA XIST promotes cell growth and metastasis through regulating miR-139-5p mediated Wnt/β-catenin signaling pathway in bladder cancer

Hu, Yangyang; Deng, Chuiwen; Zhang, He; Zhang, Jing; Peng, Bo; Hu, Chuanyi

doi:10.18632/oncotarget.21791

Cited by 74 publications

(80 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Numerous studies have suggested the importance of Wnt-b-catenin signaling in several cancers (44). Furthermore, Wnt-b-catenin has been shown to play important roles during epithelial-mesenchymal transition (45), cell proliferation and metastasis (24), and drag resistance (46) in bladder cancer. In the present study, RBM5 knockdown activated the Wnt-b-catenin pathway by promoting the expression of b-catenin and cyclin D1 while decreasing the apoptosis marker caspase-3 at the protein level.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Down‐regulated RBM5 inhibits bladder cancer cell apoptosis by initiating an miR‐432‐5p/β‐catenin feedback loop

et al. 2019

View full text Add to dashboard Cite

RNA‐binding motif protein 5 (RBM5) acts as a tumor suppressor in various human cancers and presents with several important characteristics, such as the potentiation of apoptosis, inhibition of the cell cycle, and alternative splicing of Fas and caspase‐2 precursor mRNA. However, its role in bladder urothelial carcinoma (BUC) remains unknown. In this study, we found that RBM5 expression was significantly down‐regulated in BUC tissues when compared with the adjacent nontumor tissues. The down‐regulation of RBM5 activates ²‐catenin, which binds to the T‐cell factor/lymphocyte enhancer factor element of the miR‐432‐5p promoter and elevates the expression of miR‐432‐5p in bladder cancer cells. The up‐regulated miR‐432‐5p directly targets 3′‐UTR and depresses RBM5 expression. Thus, RBM5–miR‐432‐5p–²‐catenin forms a feedback loop in regulating bladder cancer cell apoptosis. Our findings provide evidence that the regulatory feedback loop among RBM5, miR‐432‐5p, and Wnt–²‐catenin is responsible for the progress of bladder cancer cells.—Zhang, Y.‐P., Liu, K.‐L., Wang, Y.‐X., Yang, Z., Han, Z.‐W., Lu, B.‐S., Qi, J.‐C, Yin, Y.‐W., Teng, Z.‐H., Chang, X.‐L., Li, J.‐D., Xin, H., Li, W. Down‐regulated RBM5 inhibits bladder cancer cell apoptosis by initiating an miR‐432‐5p/²‐catenin feedback loop. FASEB J. 33, 10973–10985 (2019). http://www.fasebj.org

show abstract

Section: Discussionmentioning

confidence: 99%

“…MicroRNAs (miRNAs) play a critical role in tumor progression by regulating gene expression at the posttranscriptional level. Several miRNAs, including miR-22 (20), miR-21 (21), miR-429 (22), miR-34a (23), and miR-139-5p (24), have been implicated in bladder cancer. miR-432-5p has been reported to play an important role in tumor progression.…”

mentioning

confidence: 99%

Down‐regulated RBM5 inhibits bladder cancer cell apoptosis by initiating an miR‐432‐5p/β‐catenin feedback loop

et al. 2019

View full text Add to dashboard Cite

show abstract

“…More and more studies have confirmed that lncRNAs could regulate the malignant behaviours of tumour cells through its regulation of gene expression and functions . For instance, in bladder cancer, Hu et al reported that XIST promotes cell growth and metastasis through regulating miR‐139‐5p mediated Wnt/β‐catenin signalling pathway in bladder cancer . LncRNA UCA1 Promotes mitochondrial function of bladder cancer via the miR‐195/ARL2 signalling pathway .…”

Section: Discussionmentioning

confidence: 99%

LncRNA GAS6‐AS2 promotes bladder cancer proliferation and metastasis via GAS6‐AS2/miR‐298/CDK9 axis

Xin

Wang

Pan

et al. 2018

J Cellular Molecular Medi

View full text Add to dashboard Cite

Long noncoding RNAs (lncRNAs) have been proved to play important roles in carcinogenesis and development of numerous cancers, but their biological functions in bladder cancer remain largely unknown. In this study, a novel lncRNA termed GAS6‐AS2 were primary identified, and its roles as well as mechanisms in regulating proliferation and metastasis of bladder cancer cells were investigated. Clinically, GAS6‐AS2 was significantly up‐regulated in bladder cancer tissues and positively correlated with tumour stages and poor prognosis. Moreover, expression of GAS6‐AS2 was also increased in bladder cancer cells compared with normal bladder cells. Further investigating the roles of GAS6‐AS2, we found GAS6‐AS2 regulated proliferation and proliferative activity of bladder cancer cells via inducing G1 phase arrest. What's more, we found that GAS6‐AS2 contributed to metastatic abilities of cells. In mechanism, GAS6‐AS2 could function as a competitive endogenous RNA (ceRNA) via direct sponging miR‐298, which further regulating the expression of CDK9. Finally, we also proved that GAS6‐AS2 knockdown suppressed tumour growth and metastasis in vivo. In conclusion, our study proved that GAS6‐AS2 could function as a ceRNA and promote the proliferation and metastasis of bladder cancer cells, which provided a novel prognostic marker for bladder cancer patients in clinic.

show abstract

“…As we mentioned, Wnt/β-catenin signaling was involved in TGFβ1-mediated fibrosis, and miR-139 could target to inhibit several crucial factors in Wnt signaling pathway, such as CTNNB1, FZD4 (Long et al, 2017), TCF-4 (Gu et al, 2014), and Wnt1 (Hu et al, 2017). Apart from these factors, Kaiso/CTNND1 complex has been regarded as a modulator of the canonical Wnt/β-catenin signaling pathway (Kantidze, Kamalyukova, & Razin, 2009).…”

Section: Smad2/3/4 Complex Inhibits the Transcription Of Mir-139 Bymentioning

confidence: 99%

“…Under TGFβ1 stimulation, miRNA‐200b stimulates the proliferation of HTFs by targeting p27/kip1 and RND3 (Tong et al, ). More important, miR‐139 has been reported to regulate several crucial factors in Wnt signaling, including CTNNB1, FZD4 (Long et al, ), TCF‐4 (Gu, Li, & Wang, ), and Wnt1 (Hu et al, ), which inspired us to speculate that miR‐139 may participate in TGFβ1‐mediated HTF activation and proliferation through Wnt signaling.…”

Section: Introductionmentioning

confidence: 99%

The Smad2/3/4 complex binds miR‐139 promoter to modulate TGFβ‐induced proliferation and activation of human Tenon's capsule fibroblasts through the Wnt pathway

Deng

Hou

Tong

et al. 2019

Journal Cellular Physiology

View full text Add to dashboard Cite

The activation and proliferation of human Tenon's fibroblasts (HTFs) play a vital role in the fibrosis in the pathology of the scar formation after the glaucoma filtration surgery. Transforming growth factor β1 (TGFβ1)/Smads signaling has been reported to promote fibrosis. In our previous study, we revealed that TGFβ1‐induced orbital fibroblast activation and proliferation through Wnt/β‐catenin signaling. As microRNA (miR)‐139 could target several factors in Wnt signaling to modulate fibrosis, here, the effect and mechanism of miR‐139 in HTF activation and proliferation were investigated. miR‐139 overexpression significantly reversed the TGFβ1‐induced increase in collagen I and α‐smooth muscle actin contents and proliferation in HTFs. CTNNB1 and CTNND1 were direct downstream of miR‐139 and can significantly restore the suppressive effect of miR‐139 on the activation and proliferation in HTFs under TGFβ1 stimulation. Smad2/3/4 complex inhibits the transcription activity of miR‐139, most possibly by Smad4 binding to the miR‐139 promoter. Taken together, we demonstrated a new mechanism of HTF activation and proliferation from the perspective of miRNA regulation, which may provide new strategies for improving the fibrosis after the glaucoma filtration surgery.

show abstract

Long non-coding RNA XIST promotes cell growth and metastasis through regulating miR-139-5p mediated Wnt/β-catenin signaling pathway in bladder cancer

Cited by 74 publications

References 45 publications

Down‐regulated RBM5 inhibits bladder cancer cell apoptosis by initiating an miR‐432‐5p/β‐catenin feedback loop

Down‐regulated RBM5 inhibits bladder cancer cell apoptosis by initiating an miR‐432‐5p/β‐catenin feedback loop

LncRNA GAS6‐AS2 promotes bladder cancer proliferation and metastasis via GAS6‐AS2/miR‐298/CDK9 axis

The Smad2/3/4 complex binds miR‐139 promoter to modulate TGFβ‐induced proliferation and activation of human Tenon's capsule fibroblasts through the Wnt pathway

Contact Info

Product

Resources

About