Long non-coding RNA UASR1 promotes proliferation and migration of breast cancer cells through the AKT/mTOR pathway

Cao, Zhe; Wu, Ping; Su, Min; Ling, Hong-Yan; Khoshaba, Ramina; Huang, Chenfei; Han, Gao Rong; Zhao, Yan; Chen, Jinjun; Liao, Qianjin; Cao, Deliang; Jin, Junfei; Zhang, Xuewen

doi:10.7150/jca.29457

Cited by 15 publications

(14 citation statements)

References 37 publications

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“…[ 24 25 26 ] For example, UASR1 has a high expression in BC tissues and promotes cancer cell growth, proliferation, wound healing and migration through the AKT/mTOR signaling pathway. [27] MALAT1 is considered an oncogenic regulator of BC, which accelerates angiogenesis through miR-145 in MCF-7 cells to enhance aggressiveness of BC. [28] Its worth noting that some lncRNAs have been regarded as potential prognosis markers for BC, according to the previous researches.…”

Section: Discussionmentioning

confidence: 99%

Long non-coding RNA-based signatures to improve prognostic prediction of breast cancer

Zhang¹,

Wang²,

Tian

et al. 2020

Medicine

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Section: Discussionmentioning

confidence: 99%

Long non-coding RNA-based signatures to improve prognostic prediction of breast cancer

Zhang¹,

Wang²,

Tian

et al. 2020

Medicine

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“…The functionality of UASR1 has only been investigated in breast cancer ( 13 ). It was observed that UASR1 was upregulated in breast cancer and that it interacted with the AKT/mTOR pathway to promote the migration and proliferation of CRC cells.…”

Section: Discussionmentioning

confidence: 99%

“…However, the functions of most lncRNAs remain elusive. lncRNA UASR1 (UASR1) has been characterized as an oncogenic lncRNA in breast cancer ( 13 ). In a recent study, UASR1 was reported to promote the proliferation of CRC cells by interacting with the mTOR pathway ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

lncRNA UASR1 sponges miR‑107 in colorectal cancer to upregulate oncogenic CDK8 and promote cell proliferation

Zhang

Chen

2020

Oncol Lett

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lncRNA UASR1 (UASR1) has been characterized as an oncogenic lncRNA in breast cancer. UASR1 was predicted to interact with miR-107, which serves tumor suppressive roles mainly by targeting CDK8. The present study was performed to investigate the interactions among UASR1, miR-107 and CDK8 in colorectal cancer (CRC). A total of 62 patients with CRC, including 40 males and 22 females (age range, 38–67 years; mean age, 57.2±7.6 years) were enrolled at the Second Hospital of Shandong University between July 2012 and July 2014. The expression of UASR1 in tissues and cells were detected by reverse transcription-quantitative polymerase chain reaction. The interaction between UASR1 and miR-107 was investigated by performing dual luciferase activity assay, and the effects of overexpression of UASR1, miR-107 and CDK8 on the proliferation of CR4 cells were analyzed by performing cell proliferation analysis. It was observed that UASR1 is upregulated in CRC and its high expression levels predicted poor survival in patients with CRC. RNA-RNA interaction prediction demonstrated that UASR1 may interact with miR-107. In CRC cells, overexpression of UASR1 and miR-107 did not affect each other. However, the expression of CDK8, a target of miR-107, was upregulated following overexpression of UASR1. Notably, overexpression of UASR1 decreased the inhibitory effects of miR-107 on cell proliferation and the expression of CDK8. Therefore, UASR1 may sponge miR-107 to upregulate oncogenic CDK8, thereby promoting CRC cell proliferation.

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“…Until now, there are only several literatures correlated with UNC5B-AS1 in cancers can be searched. These studies reveal that UNC5B-AS1 is upregulated and relevant to proliferation, migration and invasion in ovarian cancer, breast cancer, thyroid cancer and colon cancer [28][29][30][31]. However, there have no reports of UNC5B-AS1 in GBM.…”

Section: Discussionmentioning

confidence: 99%

A long non-coding RNA signature predicts survival for glioblastoma as prognostic biomarkers

Z¹,

Z²,

Lu³

et al. 2020

Preprint

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Background: Glioblastoma (GBM) is one of the most fatal tumors in the central nervous system. Its prognosis is very poor. There is increasing evidence that long noncoding RNA (lncRNA) participates in the biological process of glioblastoma. Nevertheless, the role of lncRNA in predicting the prognosis of GBM is still uncertain. Methods: In this study, using RNA-Seq and clinical follow-up data of GBM patients from The Cancer Genome Atlas (TCGA), we performed differential analysis of lncRNA, univariable and multivariable Cox regression analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, and Gene Ontology (GO) analysis.Results: We identified four lncRNAs closely interrelated with survival and prognosis of GBM patients. This lncRNA signature was effective in both the training set and the testing set, and it was independent to clinical factors.Conclusions: Our data suggested that the four lncRNAs could be used as promising biomarkers for predicting prognosis in GBM patients.

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Long non-coding RNA UASR1 promotes proliferation and migration of breast cancer cells through the AKT/mTOR pathway

Cited by 15 publications

References 37 publications

Long non-coding RNA-based signatures to improve prognostic prediction of breast cancer

Long non-coding RNA-based signatures to improve prognostic prediction of breast cancer

lncRNA UASR1 sponges miR‑107 in colorectal cancer to upregulate oncogenic CDK8 and promote cell proliferation

A long non-coding RNA signature predicts survival for glioblastoma as prognostic biomarkers

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