Long Non-coding RNA ST8SIA6-AS1 Promotes Lung Adenocarcinoma Progression Through Sponging miR-125a-3p

Cao, Qiang; Yang, Weiqin; Ji, Xili; Wang, Wei

doi:10.3389/fgene.2020.597795

Cited by 9 publications

(9 citation statements)

References 25 publications

(26 reference statements)

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“…ST8Sia6 generates disialic acid structures, eventually by transfer of a sialic acid moiety onto a NeuAca2,3 (6)Gal disaccharide on acceptor substrates, which include glycolipids, but preferentially O-linked glycoproteins (234). Some investigators suggest that ST8SIA6 Antisense RNA 1 (ST8SIA6-AS1) is associated with poor prognosis and enhances the proliferative and metastatic potential of cancer cells (235)(236)(237)(238)(239)(240). Furthermore, ST8Sia6 may increase the chemosensitivity of tumor cells at least to certain drugs (226).…”

Section: St8sia6mentioning

confidence: 99%

The Distinct Roles of Sialyltransferases in Cancer Biology and Onco-Immunology

et al. 2021

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Aberrant glycosylation is a key feature of malignant transformation. Hypersialylation, the enhanced expression of sialic acid-terminated glycoconjugates on the cell surface, has been linked to immune evasion and metastatic spread, eventually by interaction with sialoglycan-binding lectins, including Siglecs and selectins. The biosynthesis of tumor-associated sialoglycans involves sialyltransferases, which are differentially expressed in cancer cells. In this review article, we provide an overview of the twenty human sialyltransferases and their roles in cancer biology and immunity. A better understanding of the individual contribution of select sialyltransferases to the tumor sialome may lead to more personalized strategies for the treatment of cancer.

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Section: St8sia6mentioning

confidence: 99%

The Distinct Roles of Sialyltransferases in Cancer Biology and Onco-Immunology

et al. 2021

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“…Some of these are pseudogenes, but the majority are non-protein coding genes—small nuclear RNAs, small nucleolar RNAs or long noncoding RNAs—with the exception being WDR74, a 60S ribosome assembly factor which has been shown to promote lung cancer growth and metastasis ( 69 ). Of the noncoding genes among the top 20, SNORD13 ( 70 ), ST8SIA6-AS1 ( 71 , 72 ) and Y RNA ( 73 ) have been shown to have altered expression in NSCLC or in lung adenocarcinoma specifically.…”

Section: Resultsmentioning

confidence: 99%

Identification of differentially distributed gene expression and distinct sets of cancer-related genes identified by changes in mean and variability

Roberts¹,

Catchpoole²,

Kennedy³

2022

NAR Genomics and Bioinformatics

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There is increasing evidence that changes in the variability or overall distribution of gene expression are important both in normal biology and in diseases, particularly cancer. Genes whose expression differs in variability or distribution without a difference in mean are ignored by traditional differential expression-based analyses. Using a Bayesian hierarchical model that provides tests for both differential variability and differential distribution for bulk RNA-seq data, we report here an investigation into differential variability and distribution in cancer. Analysis of eight paired tumour–normal datasets from The Cancer Genome Atlas confirms that differential variability and distribution analyses are able to identify cancer-related genes. We further demonstrate that differential variability identifies cancer-related genes that are missed by differential expression analysis, and that differential expression and differential variability identify functionally distinct sets of potentially cancer-related genes. These results suggest that differential variability analysis may provide insights into genetic aspects of cancer that would not be revealed by differential expression, and that differential distribution analysis may allow for more comprehensive identification of cancer-related genes than analyses based on changes in mean or variability alone.

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“…It has been reported that lncRNAs exert biological functions in regulating genes that influence tumor cell proliferation, migration, invasion and apoptosis (Chen et al, 2017;Cao et al, 2020;Huang et al, 2020;Zeng et al, 2020). For instance, in bladder cancer, Liu et reported that lncRNA SPRY4-IT1 promote bladder cancer cells proliferation and metastasis (Liu et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

KCNMB2-AS1 Promotes Bladder Cancer Progression Through Sponging miR-374a-3p to Upregulate S100A10

et al. 2021

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Long non-coding RNAs (lncRNAs) have been reported to play a crucial role in the pathogenesis of numerous cancers. However, the function of lncRNA KCNMB2-AS1 in bladder cancer (BC) remains unclear. In the present study, we aimed to explore the role and underlying mechanisms of KCNMB2-AS1 in bladder cancer progression. We found that lncRNA KCNMB2-AS1 was significantly upregulated both in BC tissues and cell lines, the expression level was highly correlated with pathological TNM stage. Functionally, knockdown of lncRNA KCNMB2-AS1 dramatically inhibited the proliferation, migration, and invasion and of BC cells in vitro, and suppressed tumor growth in vivo. Mechanistically, lncRNA KCNMB2-AS1 could function as a competitive endogenous RNA (ceRNA) through direct sponging miR-374a-3p, which regulated the expression of S100A10. In conclusion, our results demonstrated that lncRNA KCNMB2-AS1 can promote the progression of bladder cancer through regulation of miR-374a-3p/S100A10.

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Long Non-coding RNA ST8SIA6-AS1 Promotes Lung Adenocarcinoma Progression Through Sponging miR-125a-3p

Cited by 9 publications

References 25 publications

The Distinct Roles of Sialyltransferases in Cancer Biology and Onco-Immunology

The Distinct Roles of Sialyltransferases in Cancer Biology and Onco-Immunology

Identification of differentially distributed gene expression and distinct sets of cancer-related genes identified by changes in mean and variability

KCNMB2-AS1 Promotes Bladder Cancer Progression Through Sponging miR-374a-3p to Upregulate S100A10

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