Long non-coding RNA SNHG15 interacts with and stabilizes transcription factor Slug and promotes colon cancer progression

Jiang, Hao; Li, Tingting; Qu, Yi; Wang, Xiang; Li, Bing; Song, Jianguo; Sun, Xiaoran; Tang, Yan; Wan, Junhu; Yu, Yu; Zhan, Jun; Zhang, Hongquan

doi:10.1016/j.canlet.2018.03.038

Cited by 113 publications

(154 citation statements)

References 26 publications

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“…16,18 Although association between SNHG15 expression and overall survival time have been explored in various human cancers such as lung cancer, 12,13 breast cancer, 14 hepatocellular carcinoma, 15 gastric cancer, 16 colon cancer, 17 and pancreatic cancer, 18 little is known about the prognostic value of SNHG15 expression in patients with thyroid cancer. 14 Moreover, SNHG15 overexpression also has been showed to act as poor prognostic factor in digestive system tumors including hepatocellular carcinoma, 15 gastric cancer, 16 colon cancer, 17 and pancreatic cancer. On the contrary, patients with non-small-cell lung cancer with low SNHG15 expression had obviously longer disease-free survival and overall survival than patients with high SNHG15 expression.…”

Section: Discussionmentioning

confidence: 99%

SNHG15 functions as a tumor suppressor in thyroid cancer

Liu

et al. 2019

J of Cellular Biochemistry

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Small nucleolar RNA host gene 15 (SNHG15) has been suggested to be overexpressed, and function as an oncogenic long noncoding RNA (lncRNA) in various types of human malignancies. However, the expression status and function of SNHG15 were still unknown in thyroid cancer. In our study, we assessed the expression status and clinical value in thyroid cancer samples, and explored the effect of SNHG15 on thyroid cancer cell proliferation, migration, and invasion. In results, SNHG15 expression was downregulated in thyroid cancer tissues and cells, and correlated with age, pathology classification, clinical stage, tumor size, distant metastasis, and disease‐free survival. The in vitro studies suggested SNHG15 overexpression suppressed cell proliferation, migration, and invasion in thyroid cancer. In summary, SNHG15 serves as tumor suppressive role in thyroid cancer.

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Section: Discussionmentioning

confidence: 99%

SNHG15 functions as a tumor suppressor in thyroid cancer

Liu

et al. 2019

J of Cellular Biochemistry

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“…DANCR could upregulate colon cancer cell proliferation and migration ability by sponging MIR577 and increase the expression of HSPB1 . Huang et al and Zhang et al concluded that SNHG15 and SNHG16 were both highly expressed in colon cancer samples . SNHG15 could only increase the protein level of SNAI2 but not the mRNA level through preventing SNAI2’s ubiquitin .…”

Section: Biological Functions and Mechanisms Of Snhgs In Digestive Camentioning

confidence: 99%

“…Huang et al and Zhang et al concluded that SNHG15 and SNHG16 were both highly expressed in colon cancer samples . SNHG15 could only increase the protein level of SNAI2 but not the mRNA level through preventing SNAI2’s ubiquitin . Wnt signaling pathway and ceRNA mechanism might participate in the progression of SNHG16 .…”

Section: Biological Functions and Mechanisms Of Snhgs In Digestive Camentioning

confidence: 99%

Long non‐coding small nucleolar RNA host genes in digestive cancers

et al. 2019

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Although long noncoding RNAs (lncRNAs) do not have protein coding capacities, they are involved in the pathogenesis of many types of cancers, including hepatocellular carcinoma, cervical cancer, and gastric cancer. Notably, the roles of lncRNAs are vital in nearly every aspect of tumor biology. Long non‐coding small nucleolar RNA host genes (lnc‐SNHGs) are abnormally expressed in multiple cancers, including urologic neoplasms, respiratory tumors, and digestive cancers, and play vital roles in these cancers. These host genes could participate in tumorigenesis by regulating proliferation, migration, invasion and apoptosis of tumor cells. This review focuses on the overview of the roles that lnc‐SNHGs play in the formation and progression of digestive cancers.

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“…Long noncoding RNAs (lncRNAs) are a class of non‐protein‐coding transcriptions with the length of more than 200 nucleotides . It is widely reported that lncRNAs are involved in multiple malignant tumors including OS . Metastasis‐associated lung adenocarcinoma transcript 1 (MALAT1) is located at chromosome 11q13.1 and is discovered as a new cancer‐associated lncRNAs in various cancers .…”

Section: Introductionmentioning

confidence: 99%

Long noncoding RNA MALAT1 regulates HDAC4‐mediated proliferation and apoptosis via decoying of miR‐140‐5p in osteosarcoma cells

Sun

Qin

2018

Cancer Medicine

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Noncoding RNAs regulate the initiation and progression of osteosarcoma (OS). The role of long noncoding RNA metastasis‐associated lung adenocarcinoma transcript 1 (MALAT1) playing in OS and whether the function it working out was achieved through HDAC4 pathway remain uncovered. In this study, we illustrated that MALAT1 was upregulated and was correlated with poor prognosis in OS patients. Meanwhile, we demonstrated that a depression of MALAT1 suppressed proliferation and promoted apoptosis in OS cell line HOS and 143B. Further, we verified that MALAT1 exerting its function via upregulating of histone deacetylase 4 (HDAC4). Through an online prediction, a series of luciferase assays and RNA pull‐down assays, we demonstrated that both MALAT1 and HDAC4 were the targets of microRNA‐140‐5p (miR‐140‐5p) via sharing a similar microRNA responding elements. Even further, we revealed that MALAT1 served as a ceRNA of HDAC4 via decoying of miR‐140‐5p. Finally, we proved that MALAT1 promoted OS tumor growth in an in vivo animal study. In summary, the outcomes of this study demonstrated the complex ceRNA network among MALAT, miR‐140‐5p, and HDAC4‐mediated proliferation and apoptosis in OS. This study might provide a new axial in molecular treatment of OS.

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Long non-coding RNA SNHG15 interacts with and stabilizes transcription factor Slug and promotes colon cancer progression

Cited by 113 publications

References 26 publications

SNHG15 functions as a tumor suppressor in thyroid cancer

SNHG15 functions as a tumor suppressor in thyroid cancer

Long non‐coding small nucleolar RNA host genes in digestive cancers

Long noncoding RNA MALAT1 regulates HDAC4‐mediated proliferation and apoptosis via decoying of miR‐140‐5p in osteosarcoma cells

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