Long non-coding RNA RGMB-AS1 represses nasopharyngeal carcinoma progression via binding to forkhead box A1

Zhang, Tian; Jin, Ying; Luo, Xiangmei

doi:10.1080/21655979.2022.2039495

Cited by 2 publications

(3 citation statements)

References 48 publications

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“…43 It has also been reported to inhibit nasopharyngeal carcinoma development by modulating the YBX1/snail axis. 44 However, the role of LINC01133 in cancer progression is context-dependent, as it has been found to accelerate cancer progression in certain malignancies, such as cervical cancer and pancreatic cancer. 45,46 In CRC, studies have demonstrated that LINC01133 not only inhibits metastasis but also serves as a predictive marker.…”

Section: Discussionmentioning

confidence: 99%

Propofol‐induced LINC01133 inhibits the progression of colorectal cancer via miR‐186‐5p/NR3C2 axis

Yao,

Zhang,

Liu

et al. 2023

Environmental Toxicology

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Colorectal cancer (CRC) is a formidable threat to human well‐being, characterized by a largely enigmatic occurrence and progression mechanism. A growing body of literature has underscored the potential influence of propofol, a frequently administered anesthetic, on clinical outcomes in malignant tumor patients. However, the precise molecular mechanisms underlying the impact of propofol on the progression of CRC have yet to be fully elucidated. This study reveals a notable upregulation of LINC01133 expression in CRC cells subsequent to propofol treatment, which is mediated by FOXO1. Subsequently, a series of experiments were conducted to elucidate the role and mechanisms underlying propofol‐induced LINC01133 in CRC development. Our study uncovers that the upregulation of LINC01133 exerts a substantial inhibitory effect on the proliferation, migration, and invasion of CRC cells. Further investigation revealed that LINC01133 can attenuate the proliferation, invasion, and migration of CRC cell lines through the miR‐186‐5p/NR3C2 axis. Results from in vivo experiments unequivocally demonstrated a significant reduction in the growth rate of subcutaneous implant tumors upon LINC01133 overexpression in CRC cells. These findings posit that propofol induces LINC01133 expression, leading to the inhibition of CRC progression. This revelation offers a novel perspective on propofol's antitumor properties and underscores the potential of LINC01133 as a promising therapeutic target for CRC.

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Section: Discussionmentioning

confidence: 99%

Propofol‐induced LINC01133 inhibits the progression of colorectal cancer via miR‐186‐5p/NR3C2 axis

Yao,

Zhang,

Liu

et al. 2023

Environmental Toxicology

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“…In addition to the above effects on the proliferation and invasion of tumor cells, in 2018, Sanders and his group found that RGMb can also regulate the human vascular endothelial cells' responsiveness to hepatocyte growth factor, thereby inhibiting the generation of tumor neovascularization and ultimately affecting the deterioration of tumors [26]. In 2022，Zhang et al also found that RGMb affected the clinical prognosis of patients by affecting the epithelialmesenchymal transition and the malignant degree of tumors in nasopharyngeal carcinoma, through their research of the mechanism of LncRNA RGMb-AS1 in nasopharyngeal carcinoma [27]. In a nutshell, RGMb can inhibit cell proliferation, transformation, migration and invasion, initiate cell apoptosis, and interfere with tumor neovascularization so as to inhibit tumor progression.…”

Section: Tumor Progressionmentioning

confidence: 99%

“…Although due to the wide distribution of RGMb in vivo, it has aroused intense discussion in various fields worldwide, the interaction between it signaling pathways is still unclear, even contradictory. For example, in terms of tumor progression, RGMb can inhibit cell proliferation, transformation, migration and invasion, initiate cell apoptosis, and interfere with tumor neovascularization in NSCLC [23], breast cancer [19,23], liver cancer [47], squamous cell carcinoma [25], nasopharyngeal carcinoma [27] and other related tumors, so as to inhibit tumor progression and even improving survival ratio. However, Song et al mentioned in their study that LncRNA RGMb-ASI promoted cell proliferation and migration through miR-574-3p/PIM3 and inhibited cell apoptosis, thus leading to the progression of pancreatic cancer [48].…”

Section: Complexity and Contradictionmentioning

confidence: 99%

Research Progress on RGMb and its Signaling Pathway

Li¹,

Zhang²,

Zhang³

et al. 2023

IJBLS

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Repulsive guidance molecule b (RGMb) is a member of RGM family, which is structurally composed of an N-terminal signal peptide, a vWFD domain and a C-peptide. RGMb is widely expressed in different systems in order to regulate various physiological and pathophysiological processes. So RGMb involves in tumor progression, immune regulation, retinal network, neural network reconstruction and other important aspects. Recently, numerous studies reflect the diversity and complexity of RGMb signaling pathway. This paper will focus on RGMb, and introduce its molecule structure, function, related signaling pathway, and above all, the research progresses.

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Long non-coding RNA RGMB-AS1 represses nasopharyngeal carcinoma progression via binding to forkhead box A1

Cited by 2 publications

References 48 publications

Propofol‐induced LINC01133 inhibits the progression of colorectal cancer via miR‐186‐5p/NR3C2 axis

Propofol‐induced LINC01133 inhibits the progression of colorectal cancer via miR‐186‐5p/NR3C2 axis

Research Progress on RGMb and its Signaling Pathway

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