Long non-coding RNA regulating androgen receptor signaling in breast and prostate cancer

Kumar, Shashank; Prajapati, Kumari Sunita; Singh, Atul Kumar; Kushwaha, Prem Prakash; Shuaib, Mohd; Gupta, Sanjay

doi:10.1016/j.canlet.2020.11.039

“…PRICKLE2-AS1, FAM13A-AS1, C15orf54, and LINC00304 were identified as high-risk DESRlncRNAs that correlated with high ESCA severity. Previous study has demonstrated that LINC00304 directly promotes cell proliferation and cell cycle progression in prostate cancer (47). PRICKLE2-AS1 has been shown to be differentially methylated in vulvar squamous cell carcinoma (48) and FAM13A-AS1 is involved in regulating RNA splicing and mRNA processing in thyroid cancer (49).…”

Section: Discussionmentioning

confidence: 94%

Stemness-related gene signature for predicting therapeutic response in patients with esophageal cancer

Zhu¹,

Zhang²,

You³

et al. 2022

Transl Cancer Res TCR

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Background: Extensive research has indicated that tumor stemness promotes tumor progression. However, the underlying role of stemness-related genes (SRGs) in esophageal cancer (ESCA) remains unclear.Methods: This study identified differentially expressed stemness-related (DESR) messenger RNAs (mRNAs), microRNAs (miRNAs), and long non-coding RNAs (lncRNAs) in ESCA, and correlated them with the clinical features of patients with ESCA to develop a prognostic risk assessment model. Functional analysis, protein-protein interaction (PPI) analysis, competing endogenous RNA (ceRNA) networks, and tumor-infiltrating immune cell analyses were performed to corroborate the results obtained from the model.Results: Correlation analysis of the stemness enrichment scores revealed 1,106 DESR genes (DESRGs), 84 DESRmiRNAs, and 320 DESRlncRNAs were identified from The Cancer Genome Atlas Esophageal Carcinoma (TCGA-ESCA) dataset. Network clustering was performed and the top 20 connection points were identified, including CDC20 that connects to 136 adjacent nodes. A ceRNA network was constructed, including 17 DESRmiRNAs, 44 DESRlncRNAs, and 55 DESRGs.Conclusions: NCAPG [log 2 fold change (FC) =1.81; q value =2.68×10 −11 ] was significantly upregulated in ESCA and positively correlated with resting natural killer (NK) cells, suggesting that human NK cells rest via the overexpression of NCAPG in ESCA. hsa-miR-1269a is significantly upregulated in ESCA patients with poor prognostic features. CD4 + resting memory T cells (P<0.01) were significantly negatively correlated with hsa-miR-1269a. The insights presented in this study will contribute to the development of innovative therapeutics for the treatment of patients with ESCA.

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“…The current research and application of AR are mainly in prostate cancer and breast cancer ( Heinlein and Chang, 2002 ; Li et al, 2019 ). Several studies have been reported on the involvement of LncRNA in the regulation of AR ( Collina et al, 2019 ; Kumar et al, 2021 ). In Philling et al study, activation of AR increased cell viability and survival and attenuated G2/M arrest.…”

Section: Discussionmentioning

confidence: 99%

Systematic pan-cancer analysis on the expression and role of regulator of chromatin condensation 1/small nucleolar RNA host gene 3/small nucleolar RNA host gene 12

Hu

¹

,

Yu

²

,

Liu

³

et al. 2022

Front. Mol. Biosci.

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Regulator of chromatin condensation 1 (RCC1) is the major guanine nucleotide exchange factor of RAN GTPase, which plays a key role in various biological processes such as cell cycle and DNA damage repair. Small nucleolar RNA host gene 3 (SNHG3) and small nucleolar RNA host gene12 are long-stranded non-coding RNAs (lncRNAs) and are located on chromatin very close to the sequence of Regulator of chromatin condensation 1. Many studies have shown that they are aberrantly expressed in tumor tissues and can affect the proliferation and viability of cancer cells. Although the effects of Regulator of chromatin condensation 1/small nucleolar RNA host gene 3/small nucleolar RNA host gene12 on cellular activity have been reported, respectively, their overall analysis on the pan-cancer level has not been performed. Here, we performed a comprehensive analysis of Regulator of chromatin condensation 1/small nucleolar RNA host gene 3/small nucleolar RNA host gene12 in 33 cancers through the Cancer Genome Atlas and Gene Expression Database. The results showed that Regulator of chromatin condensation 1/small nucleolar RNA host gene 3/small nucleolar RNA host gene12 were highly expressed in a variety of tumor tissues compared to normal tissues. The expression of Regulator of chromatin condensation 1/small nucleolar RNA host gene 3/small nucleolar RNA host gene12 in BRCA, LGG and LIHC was associated with TP53 mutations. In addition, Regulator of chromatin condensation 1/small nucleolar RNA host gene 3/small nucleolar RNA host gene12 expression was closely associated with the prognosis of patients with multiple tumors. Immunocorrelation analysis indicated that Regulator of chromatin condensation 1/small nucleolar RNA host gene 3/small nucleolar RNA host gene12 showed a correlation with multiple immune cell infiltration. The results of enrichment analysis suggested that Regulator of chromatin condensation 1/small nucleolar RNA host gene 3/small nucleolar RNA host gene12 was involved in the regulation of cell cycle, apoptosis and other pathways. We found that these effects were mainly mediated by Regulator of chromatin condensation 1, while the trend of small nucleolar RNA host gene 3/small nucleolar RNA host gene12 regulation was also consistent with regulator of chromatin condensation 1. The important role played by Regulator of chromatin condensation 1 in tumor diseases was further corroborated by the study of adjacent lncRNAs.These findings provide new and comprehensive insights into the role of Regulator of chromatin condensation 1/small nucleolar RNA host gene 3/small nucleolar RNA host gene12 in tumor development and show their potential as clinical monitoring and therapy.

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“…The current research and application of AR are mainly in prostate cancer and breast cancer [51,52]. Several studies have been reported on the involvement of LncRNA in the regulation of AR [53,54]. In Philling et al study, activation of AR increased cell viability and survival and attenuated G2/M arrest.…”

Section: Discussionmentioning

confidence: 99%

Systematic Pan-cancer Analysis on the Expression and Role of RCC1/SNHG3/SNHG12

Zhang

¹

,

Hu

²

,

Yu

³

et al. 2022

Preprint

0

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Regulator of chromatin condensation 1 (RCC1) is the major guanine nucleotide exchange factor of RAN GTPase, which plays a key role in various biological processes such as cell cycle and DNA damage repair. Small nucleolar RNA host gene 3 (SNHG3) and SNHG12 are long-stranded non-coding RNAs (lncRNAs) and are located on chromatin very close to the sequence of RCC1. Many studies have shown that they are aberrantly expressed in tumor tissues and can affect the proliferation and viability of cancer cells. Although the effects of RCC1/SNHG3/SNHG12 on cellular activity have been reported, respectively, their overall analysis on the pan-cancer level has not been performed. Here, we performed a comprehensive analysis of RCC1/SNHG3/SNHG12 in 33 cancers through the Cancer Genome Atlas and Gene Expression Database. The results showed that RCC1/SNHG3/SNHG12 were highly expressed in a variety of tumor tissues compared to normal tissues. The expression of RCC1/SNHG3/SNHG12 in BRCA, LGG and LIHC was associated with TP53 mutations. In addition, RCC1/SNHG3/SNHG12 expression was closely associated with the prognosis of patients with multiple tumors. Immunocorrelation analysis indicated that RCC1/SNHG3/SNHG12 showed a correlation with multiple immune cell infiltration. The results of enrichment analysis suggested that RCC1/SNHG3/SNHG12 was involved in the regulation of cell cycle, apoptosis and other pathways. We found that these effects were mainly mediated by RCC1, while the trend of SNHG3/SNHG12 regulation was also consistent with RCC1. We refer to this phenomenon as "homodomain effect". These findings provide new and comprehensive insights into the role of RCC1/SNHG3/SNHG12 in tumor development and show their potential as clinical monitoring and therapy.

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Long non-coding RNA regulating androgen receptor signaling in breast and prostate cancer

Cited by 23 publications

References 73 publications

Stemness-related gene signature for predicting therapeutic response in patients with esophageal cancer

Stemness-related gene signature for predicting therapeutic response in patients with esophageal cancer

Systematic pan-cancer analysis on the expression and role of regulator of chromatin condensation 1/small nucleolar RNA host gene 3/small nucleolar RNA host gene 12

Systematic Pan-cancer Analysis on the Expression and Role of RCC1/SNHG3/SNHG12

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