Long non-coding RNA PVT1 indicates a poor prognosis of glioma and promotes cell proliferation and invasion via target EZH2

Yang, Anqiang; Wang, Handong; Yang, Xiaobing

doi:10.1042/bsr20170871

Cited by 35 publications

(23 citation statements)

References 24 publications

(27 reference statements)

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“…For instance, Xue et al [41] unraveled that knockdown of PVT1 weakened the malignant behaviors of glioma cells via the inhibition of cell motility and invasiveness. Yang et al [42] also substantiated that downregulation of PVT1 expression resulted in decreased cell viability and mobility and increased apoptosis. In addition, lncRNAs can act as competing endogenous RNA sponges for miRNAs to regulate the degradation of miRNA targets, thereby influencing post-transcriptional regulation [43].…”

Section: Discussionmentioning

confidence: 90%

LncRNA PVT1 Facilitates Tumorigenesis and Progression of Glioma via Regulation of MiR-128-3p/GREM1 Axis and BMP Signaling Pathway

Zhang

et al. 2018

Neurotherapeutics

133

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The current research was aimed at probing into the role of long noncoding RNA (lncRNA) PVT1 in the pathogenesis of glioma and the regulatory mechanism of PVT1/miR-128-3p/GREM1 network in glioma via regulation of the bone morphogenetic protein (BMP) signaling pathway. Microarray analysis was used for preliminary screening for candidate lncRNAs and mRNAs in glioma tissues. Real-time quantitative polymerase chain reaction, Western blot, MTT assay, flow cytometry, migration and invasion assays, and xenograft tumor model were utilized to examine the influence of the lncRNA PVT1/miR-128-3p/GREM1 network on the biological functions of glioma cells. Luciferase assay and RNA-binding protein immunoprecipitation assay were used to validate the miR-128-3p-target relationships with lncRNA PVT1 or GREM1. In addition, the impact of GREM1 on BMP signaling pathway downstream proteins BMP2 and BMP4 was detected via Western blot. LncRNA PVT1 was highly expressed in human glioma tissues and significantly associated with WHO grade (I-II vs III-IV; p < 0.05). There existed a regulatory relationship between lncRNA PVT1 and miR-128-3p as well as that between miR-128-3p and GREM1. MiR-128-3p was downregulated, whereas GREM1 was upregulated in glioma tissues in comparison with para-carcinoma tissues. Overexpression of GREM1 promoted the proliferation and metastatic potential of glioma cells, whereas miR-128-3p mimics inhibited the glioma cell activity through targeting GREM1. Furthermore, lncRNA PVT1 acted as a sponge of miR-128-3p and, thus, influenced the BMP signaling pathway downstream proteins BMP2 and BMP4 through regulating GREM1. LncRNA PVT1 modulated GREM1 and BMP downstream signaling proteins through sponging miR-128-3p, thereby promoting tumorigenesis and progression of glioma.

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Section: Discussionmentioning

confidence: 90%

LncRNA PVT1 Facilitates Tumorigenesis and Progression of Glioma via Regulation of MiR-128-3p/GREM1 Axis and BMP Signaling Pathway

Zhang

et al. 2018

Neurotherapeutics

133

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“…[7][8][9] Originally, NF-κB interacting lncRNA (NKILA) was found to be as a lncRNA mediated by NF-κB signaling pathway inducing inflammatory cytokines such as TNF-α and IL-1β in breast cancer cell. [7][8][9] Originally, NF-κB interacting lncRNA (NKILA) was found to be as a lncRNA mediated by NF-κB signaling pathway inducing inflammatory cytokines such as TNF-α and IL-1β in breast cancer cell.…”

Section: Introductionmentioning

confidence: 99%

LncRNA NKILA correlates with the malignant status and serves as a tumor‐suppressive role in rectal cancer

Tao

Yang

et al. 2018

J of Cellular Biochemistry

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NF-κB interacting lncRNA (NKILA) has been found to function as a tumor-suppressive role in various human cancers. However, the role of NKILA in rectal cancer is still unknown. The objective of this study is to investigate the clinical value and biological function of NKILA in rectal cancer. The association between NKILA expression and clinical variables including prognosis was estimated in rectal cancer patients. The gain-of-function study of NKILA in rectal cancer cell was conducted to evaluate the effect of NKILA on cell proliferation, migration, invasion, and NF-κB signaling pathway. The results suggested NKILA expression was decreased in rectal cancer tissues and cells, and correlated with clinical stage, T classification, N classification and M classification. NKILA low-expression was an independent poor prognostic factor in rectal cancer patients. NKILA-inhibited rectal cancer cell proliferation, migration, and invasion via suppressing NF-κB signaling. In conclusion, NKILA serves as an antioncogenic lncRNA in rectal cancer.

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“…Long non-coding RNAs (LncRNAs) is a wide variety of RNA transcripts of sizes greater than 200 nucleotides (nt) that lack significant protein-coding capacity [ 8 ]. Recently, several lncRNAs have been suggested to as key elements of glioma tumorigenesis, such as DANCR [ 9 , 10 ], PVT1 [ 11 ], SNHG6 [ 12 ], XIST [ 13 ], HOTTIP [ 14 ], H19 [ 15 ], HULC [ 16 ] and so on.…”

Section: Introductionmentioning

confidence: 99%

LINC00675 is a prognostic factor and regulates cell proliferation, migration and invasion in glioma

Wang

2018

Bioscience Reports

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LINC00675 has been suggested to be dysregulated in gastric cancer, colorectal cancer and pancreatic cancer. However, the expression status and biological function of LINC00675 in glioma were still unknown. Thus, we reported LINC00675 was overexpressed in glioma tissues and cell lines, and positively associated with advanced WHO grade, large tumor size and poor prognosis. Moreover, univariate and multivariate analyses suggested that high-expression of LINC00675 was an independent unfavorable prognostic predictor for glioma. In addition, levels of LINC00675 expression were positively correlated with TRIP6 mRNA and protein expressions. The in vitro experiment showed that silencing of LINC00675 inhibits glioma cell proliferation, migration and invasion through regulating TRIP6. In conclusion, LINC00675 acts as a tumor promoter in glioma progression.

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Long non-coding RNA PVT1 indicates a poor prognosis of glioma and promotes cell proliferation and invasion via target EZH2

Cited by 35 publications

References 24 publications

LncRNA PVT1 Facilitates Tumorigenesis and Progression of Glioma via Regulation of MiR-128-3p/GREM1 Axis and BMP Signaling Pathway

LncRNA PVT1 Facilitates Tumorigenesis and Progression of Glioma via Regulation of MiR-128-3p/GREM1 Axis and BMP Signaling Pathway

LncRNA NKILA correlates with the malignant status and serves as a tumor‐suppressive role in rectal cancer

LINC00675 is a prognostic factor and regulates cell proliferation, migration and invasion in glioma

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