Long non-coding RNA Opa interacting protein 5-antisense RNA 1 binds to micorRNA-34a to upregulate oncogenic PD-L1 in non-small cell lung cancer

Qiao, Xinwei; Zhao, Feng

doi:10.1080/21655979.2022.2036904

Cited by 7 publications

(4 citation statements)

References 39 publications

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“…In co-culture with lung cancer A549 cells, CAFs transfer programmed death ligand (PD-L)1 via exosomes to the cancer cells and decrease the apoptotic effects of peripheral blood mononuclear cells (PBMC) [ 273 ]. CAF exosomes also contain high levels of Opa-interacting protein 5 antisense RNA (OIP5-AS)1, which significantly downregulates miR-142-5p [ 273 ] and miR-34a [ 274 ] by acting as a sponge, thereby upregulating PD-L1, suppressing PBMS killing activity and promoting tumor progression.…”

Section: Cancer-associated Fibroblastsmentioning

confidence: 99%

Fibroblasts as Turned Agents in Cancer Progression

Wieder

2023

Cancers

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Differentiated epithelial cells reside in the homeostatic microenvironment of the native organ stroma. The stroma supports their normal function, their G0 differentiated state, and their expansion/contraction through the various stages of the life cycle and physiologic functions of the host. When malignant transformation begins, the microenvironment tries to suppress and eliminate the transformed cells, while cancer cells, in turn, try to resist these suppressive efforts. The tumor microenvironment encompasses a large variety of cell types recruited by the tumor to perform different functions, among which fibroblasts are the most abundant. The dynamics of the mutual relationship change as the sides undertake an epic battle for control of the other. In the process, the cancer “wounds” the microenvironment through a variety of mechanisms and attracts distant mesenchymal stem cells to change their function from one attempting to suppress the cancer, to one that supports its growth, survival, and metastasis. Analogous reciprocal interactions occur as well between disseminated cancer cells and the metastatic microenvironment, where the microenvironment attempts to eliminate cancer cells or suppress their proliferation. However, the altered microenvironmental cells acquire novel characteristics that support malignant progression. Investigations have attempted to use these traits as targets of novel therapeutic approaches.

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Section: Cancer-associated Fibroblastsmentioning

confidence: 99%

Fibroblasts as Turned Agents in Cancer Progression

Wieder

2023

Cancers

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“…Lung cancer is the most common cancer with high morbidity and mortality, [1][2][3][4] and it is classified as small-cell lung cancer and nonsmall cell lung cancer (NSCLC) according to histopathology. [5] It is estimated that there are 2.2 million new cases and 1.79 million deaths of lung cancer each year. [6,7] NSCLC accounts for approximately 85% of lung cancer, [8][9][10] which has the second highest incidence rate and a 5-year survival rate is less than 15%.…”

Section: Introductionmentioning

confidence: 99%

Rational design and synthesis of 2,4‐dichloro‐6‐methyl pyrimidine derivatives as potential selective EGFR^T790M/L858R inhibitors for the treatment of non‐small cell lung cancer

Duan,

Chu,

Huang

et al. 2024

Archiv der Pharmazie

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Many patients with non‐small cell lung cancer (NSCLC) initially benefit from epidermal growth factor receptor (EGFR) targeted therapy. Unfortunately, varying degrees of resistance or side effects eventually develop. Overcoming and preventing the resistance and side effects of EGFR inhibitors has become a hot topic of research today. Based on the previous studies on AZD‐9291, we designed and synthesized two series of 2,4‐dichloro‐6‐methylpyrimidine derivatives, 19 compounds in total, as potential inhibitors of the EGFR kinase. The most promising compound, L‐18, showed better inhibitory activity (81.9%) and selectivity against EGFRT790M/L858R kinase. In addition, L‐18 showed strong antiproliferative activity against H1975 cells with an IC50 value of 0.65 ± 0.06 μM and no toxicity to normal cells (LO‐2). L‐18 was able to dose‐dependently induce the apoptosis of H1975 cells and produced a cell‐cycle‐blocking effect, and it can also dose‐dependently inhibit the migration and invasion of H1975 cells. L‐18 also showed in vivo anticancer efficacy in H1975 cells xenograft mice. We also performed a series of in vivo and in vitro toxicological evaluations of compound L‐18, which did not cause obvious injury in mice during administration. These results suggest that L‐18 may be a promising drug candidate that warrants further investigation.

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“…OIP5-AS1 inhibited miR-92a and increased cell growth and metastasis via upregulation of ITGA6 in ovarian cancer ( 19 ). OIP5-AS1 interacted with miR-34a and increased the PD-L1 expression in NSCLC cells ( 20 ). Depletion of OIP5-AS1 retarded cell growth, migration and stimulated apoptosis via targeting miR-129-5p and SOX2 in breast cancer ( 21 ).…”

Section: Introductionmentioning

confidence: 99%

LncRNA OIP5-AS1 Knockdown Targets miR-183-5p/GLUL Axis and Inhibits Cell Proliferation, Migration and Metastasis in Nasopharyngeal Carcinoma

Tang

Zen

et al. 2022

Front. Oncol.

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Nasopharyngeal carcinoma (NPC) is often associated with the infection of Epstein-Barr virus in nasopharynx and is mainly happened in South China and Southeast Asia. Recently, noncoding RNAs have been reported to regulate NPC carcinogenesis. LncRNA OIP5-AS1 participates in tumorigenesis and progression; however, the inherent mechanism of OIP5-AS1-mediated progression of NPC is unclear. In the current study, we aimed to explore the role of OIP5-AS1 in NPC progression. We measured the cell viability, apoptosis, migration, and invasion in NPC cells after OIP5-AS1 modulation. Moreover, we determined whether OIP5-AS1 exerts its oncogenic functions via sponging miR-183-5p in NPC. Furthermore, we determined whether glutamate ammonia ligase (GLUL) was a downstream target of miR-183-5p. We found that OIP5-AS1 downregulation inhibited the viability, migration and invasion of NPC via targeting miR-183-5p. We also identified that GLUL might be a potential downstream target of miR-183-5p in NPC cells. Mechanistically, OIP5-AS1 promotes cell motility via regulating miR-183-5p and GLUL in NPC cells. We concluded that OIP5-AS1 performed its biological functions via targeting miR-183-5p and GLUL in NPC cells.

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Long non-coding RNA Opa interacting protein 5-antisense RNA 1 binds to micorRNA-34a to upregulate oncogenic PD-L1 in non-small cell lung cancer

Cited by 7 publications

References 39 publications

Fibroblasts as Turned Agents in Cancer Progression

Fibroblasts as Turned Agents in Cancer Progression

Rational design and synthesis of 2,4‐dichloro‐6‐methyl pyrimidine derivatives as potential selective EGFR^T790M/L858R inhibitors for the treatment of non‐small cell lung cancer

LncRNA OIP5-AS1 Knockdown Targets miR-183-5p/GLUL Axis and Inhibits Cell Proliferation, Migration and Metastasis in Nasopharyngeal Carcinoma

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Long non-coding RNA Opa interacting protein 5-antisense RNA 1 binds to micorRNA-34a to upregulate oncogenic PD-L1 in non-small cell lung cancer

Cited by 7 publications

References 39 publications

Fibroblasts as Turned Agents in Cancer Progression

Fibroblasts as Turned Agents in Cancer Progression

Rational design and synthesis of 2,4‐dichloro‐6‐methyl pyrimidine derivatives as potential selective EGFRT790M/L858R inhibitors for the treatment of non‐small cell lung cancer

LncRNA OIP5-AS1 Knockdown Targets miR-183-5p/GLUL Axis and Inhibits Cell Proliferation, Migration and Metastasis in Nasopharyngeal Carcinoma

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Rational design and synthesis of 2,4‐dichloro‐6‐methyl pyrimidine derivatives as potential selective EGFR^T790M/L858R inhibitors for the treatment of non‐small cell lung cancer