Long non-coding RNA NONMMUG014387 promotes Schwann cell proliferation after peripheral nerve injury

Pan, Bin; Shi, Zhongju; Yan, Jiayin; Li, Jiahe; Feng, Shiqing

doi:10.4103/1673-5374.221168

Cited by 26 publications

(15 citation statements)

References 48 publications

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“…The silence of MALAT-1 could also inhibit the expression of CTHRC1 which is a positive regulator of ESCC [ 40 ]. Further, another lncRNA named NONMMUG014387 could also regulate CTHRC1 and activate the Wnt/PCP pathway to promote Schwann cell proliferation at the site of injury [ 44 ].…”

Section: The Molecules That Regulate the Expression Of Cthrc1mentioning

confidence: 99%

The Role of CTHRC1 in Regulation of Multiple Signaling and Tumor Progression and Metastasis

Mei

Zhu

Zhang

et al. 2020

Mediators of Inflammation

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Collagen triple helix repeat containing-1 (CTHRC1) has been identified as cancer-related protein. CTHRC1 expresses mainly in adventitial fibroblasts and neointimal smooth muscle cells of balloon-injured vessels and promotes cell migration and tissue repair in response to injury. CTHRC1 plays a pivotal role in some pathophysiological processes, including increasing bone mass, preventing myelination, and reversing collagen synthesis in many tumor cells. The ascended expression of CTHRC1 is related to tumorigenesis, proliferation, invasion, and metastasis in various human malignancies, including gastric cancer, pancreatic cancer, hepatocellular carcinoma, keloid, breast cancer, colorectal cancer, epithelial ovarian cancer, esophageal squamous cell carcinoma, cervical cancer, non-small-cell lung carcinoma, and melanoma. And molecules that regulate the expression of CTHRC1 include miRNAs, lncRNAs, WAIF1, and DPAGT1. Many reports have pointed that CTHRC1 could exert different effects through several signaling pathways such as TGF-β, Wnt, integrin β/FAK, Src/FAK, MEK/ERK, PI3K/AKT/ERK, HIF-1α, and PKC-δ/ERK signaling pathways. As a participant in tissue remodeling or immune response, CTHRC1 may promote early-stage cancer. Several recent studies have identified CTHRC1 as an effectual prognostic biomarker for predicting tumor recurrence or metastasis. It is worth noting that CTHRC1 has different cellular localization and mechanisms of action in different cells and different microenvironments. In this article, we focus on the advances in the signaling pathways mediated by CTHRC1 in tumors.

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Section: The Molecules That Regulate the Expression Of Cthrc1mentioning

confidence: 99%

The Role of CTHRC1 in Regulation of Multiple Signaling and Tumor Progression and Metastasis

Mei

Zhu

Zhang

et al. 2020

Mediators of Inflammation

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“…Since SCs are important glial cells in peripheral nerve and they have attractive application prospects in cell transplantation for the therapy of nervous system injury, the biology and application of SCs have been attracting a great deal of attention (Belin et al, 2017 ). Recent decades, lots of publications focused on the study of SC proliferation (Atanasoski et al, 2004 ; Deng et al, 2017 ; Pan et al, 2017 ; Piñero et al, 2017 ). As molecular switches that control the organization and dynamics of the actin cytoskeleton, Rho GTPases are considered to be key regulators of proliferation of various cells (Hu et al, 2014 ; Wang et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

“…Peripheral nerves are composed not only of axons but also of Schwann cells (SCs), which wrap around the axons and form myelin sheath (Tricaud, 2017 ). SCs are the first cells activated following PNI and play vital roles in nerve regeneration through dedifferentiation and proliferation (Pan et al, 2017 ). The proliferated SCs can organize the clearance of broken axons and myelin debris by promoting macrophage recruitment or via phagocytosis by themselves, secrete neurotrophins to facilitate the axonal regrowth, form bands of Bunger in the distal stump to provide a permissive microenvironment for axon regeneration and ensuing remyelination (Monk et al, 2015 ; Jessen and Mirsky, 2016 ; Wong et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Inhibition of RhoA-Subfamily GTPases Suppresses Schwann Cell Proliferation Through Regulating AKT Pathway Rather Than ROCK Pathway

Tan

Wen

et al. 2018

Front. Cell. Neurosci.

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Inhibiting RhoA-subfamily GTPases by C3 transferase is widely recognized as a prospective strategy to enhance axonal regeneration. When C3 transferase is administered for treating the injured peripheral nerves, Schwann cells (SCs, important glial cells in peripheral nerve) are inevitably impacted and therefore SC bioeffects on nerve regeneration might be influenced. However, the potential role of C3 transferase on SCs remains elusive. Assessed by cell counting, EdU and water-soluble tetrazolium salt-1 (WST-1) assays as well as western blotting with PCNA antibody, herein we first found that CT04 (a cell permeable C3 transferase) treatment could significantly suppress SC proliferation. Unexpectedly, using Y27632 to inhibit ROCK (the well-accepted downstream signal molecule of RhoA subfamily) did not impact SC proliferation. Further studies indicated that CT04 could inactivate AKT pathway by altering the expression levels of phosphorylated AKT (p-AKT), PI3K and PTEN, while activating AKT pathway by IGF-1 or SC79 could reverse the inhibitory effect of CT04 on SC proliferation. Based on present data, we concluded that inhibition of RhoA-subfamily GTPases could suppress SC proliferation, and this effect is independent of conventional ROCK pathway but involves inactivation of AKT pathway.

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“…Further investigation identified several potential lncRNAs for SC modulation. LncRNA NONMMUG014387 was upregulated after peripheral nerve injury and could promote SC proliferation by increasing collagen triple helix repeat containing 1 (Cthrc1) and activating Wnt/PCP pathway (Pan et al, 2017a). LncRNA BC088327 was increased with the exposure time of heregulin-1β in SCs under hypoxic conditions.…”

Section: Lncrnas In Nerve Injurymentioning

confidence: 99%

Role of Long Noncoding RNAs and Circular RNAs in Nerve Regeneration

Yao

2019

Front. Mol. Neurosci.

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Nerve injuries may cause severe disability and affect the quality of life. It is of great importance to get a full understanding of the biological processes and molecular mechanisms underlying nerve injuries to find and target specific molecules for nerve regeneration. Numerous studies have shown that noncoding RNAs (ncRNAs) participate in diverse biological processes and diseases. Long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) are two major groups of ncRNAs, which attract growing attention. The altered expression patterns of lncRNAs and circRNAs following nerve injury suggest that these ncRNAs might be associated with nerve regeneration. This review will give a brief introduction of lncRNAs and circRNAs. We then summarize the current studies on lncRNAs and circRNAs following peripheral nerve injury and spinal cord injury (SCI). Typical lncRNAs and circRNAs are introduced to illustrate the diverse molecular mechanisms for nerve regeneration. In addition, we also discuss some issues to be addressed in future investigations on lncRNAs and circRNAs.

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Long non-coding RNA NONMMUG014387 promotes Schwann cell proliferation after peripheral nerve injury

Cited by 26 publications

References 48 publications

The Role of CTHRC1 in Regulation of Multiple Signaling and Tumor Progression and Metastasis

The Role of CTHRC1 in Regulation of Multiple Signaling and Tumor Progression and Metastasis

Inhibition of RhoA-Subfamily GTPases Suppresses Schwann Cell Proliferation Through Regulating AKT Pathway Rather Than ROCK Pathway

Role of Long Noncoding RNAs and Circular RNAs in Nerve Regeneration

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