Long non-coding RNA MINCR regulates the growth and metastasis of human osteosarcoma cells via Wnt/β-catenin signaling pathway

Bai, Sunpeng; Li, Yongjiang; Wang, Yuancheng; Zhou, Gaoli; Liu, Cheng; Wen, Xiaoqing; Chen, Junfeng

doi:10.18388/abp.2020_5804

Cited by 3 publications

(2 citation statements)

References 25 publications

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“…In osteosarcoma, the knockdown of MINCR inhibited cell proliferation and migration and promoted apoptosis. Furthermore, c-Myc and cell cycle-related genes were downregulated after knockdown of MINCR expression in osteosarcoma cells (Bai et al, 2022).…”

Section: Other Types Of Cancermentioning

confidence: 97%

Oncogenic roles and related mechanisms of the long non-coding RNA MINCR in human cancers

Chao

Tang

Zhao

et al. 2023

Front. Cell Dev. Biol.

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Long non-coding RNAs (lncRNAs) play vital roles in regulating epigenetic mechanisms and gene expression levels, and their dysregulation is closely associated with a variety of diseases such as cancer. Several studies have demonstrated that lncRNAs are dysregulated during tumor progression. Recently, the MYC-induced long non-coding RNA MINCR, a newly identified lncRNA, has been demonstrated to act as an oncogene in different cancers, including gallbladder cancer, hepatocellular cancer, colorectal cancer, non-small cell lung cancer, oral squamous cell carcinoma, nasopharyngeal cancer, and glioma. Moreover, MINCR has been reported to act as a biomarker in the prognosis of patients with different cancers. In this review, we summarize and analyze the oncogenic roles of MINCR in a variety of human cancers in terms of its clinical significance, biological functions, cellular activities, and regulatory mechanism. Our analysis of the literature suggests that MINCR has potential as a novel biomarker and therapeutic target in human cancers.

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Section: Other Types Of Cancermentioning

confidence: 97%

Oncogenic roles and related mechanisms of the long non-coding RNA MINCR in human cancers

Chao

Tang

Zhao

et al. 2023

Front. Cell Dev. Biol.

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“…Similarly, lncLINC01128 regulates OS development by sponging microRNA-299-3p to mediate MMP2 expression and activate the Wnt/β-catenin signaling pathway [87]. Long non-coding RNA MINCR governs the growth and metastasis of human OS cells via the Wnt/β-catenin signaling pathway [88]. Overexpression of microRNA-135b, an oncogenic microRNA in OS, can promote OS invasion and metastasis in vitro and in vivo by activating the Wnt/β-catenin signaling pathway via directly targeting GSK-3β, APC, β-TrCP, and CK1α [89].…”

Section: Wnt/β-catenin Signaling Pathwaymentioning

confidence: 99%

Deciphering the Signaling Mechanisms of Osteosarcoma Tumorigenesis

Nirala

Yamamichi

Yustein

2023

IJMS

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Osteosarcoma (OS) is the predominant primary bone tumor in the pediatric and adolescent populations. It has high metastatic potential, with the lungs being the most common site of metastasis. In contrast to many other sarcomas, OS lacks conserved translocations or genetic mutations; instead, it has heterogeneous abnormalities, including somatic DNA copy number alteration, ploidy, chromosomal amplification, and chromosomal loss and gain. Unfortunately, clinical outcomes have not significantly improved in over 30 years. Currently, no effective molecularly targeted therapies are available for this disease. Several genomic studies showed inactivation in the tumor suppressor genes, including p53, RB, and ATRX, and hyperactivation of the tumor promoter genes, including MYC and MDM2, in OS. Alterations in the major signaling pathways, including the PI3K/AKT/mTOR, JAK/STAT, Wnt/β-catenin, NOTCH, Hedgehog/Gli, TGF-β, RTKs, RANK/RANKL, and NF-κB signaling pathways, have been identified in OS development and metastasis. Although OS treatment is currently based on surgical excision and systematic multiagent therapies, several potential targeted therapies are in development. This review focuses on the major signaling pathways of OS, and we propose a biological rationale to consider novel and targeted therapies in the future.

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Progress in understanding of relationship between inflammation and tumors

Chi

2024

WCJD

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Long non-coding RNA MINCR regulates the growth and metastasis of human osteosarcoma cells via Wnt/β-catenin signaling pathway

Cited by 3 publications

References 25 publications

Oncogenic roles and related mechanisms of the long non-coding RNA MINCR in human cancers

Oncogenic roles and related mechanisms of the long non-coding RNA MINCR in human cancers

Deciphering the Signaling Mechanisms of Osteosarcoma Tumorigenesis

Progress in understanding of relationship between inflammation and tumors

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