Long Non-coding RNA MINCR Regulates miR-876-5p/GSPT1 Axis to Aggravate Glioma Progression

Li, Zheng; Xiao-xia, Xie; Fan, Xiangyun; Li, Xing

doi:10.1007/s11064-020-03029-8

Cited by 17 publications

(9 citation statements)

References 35 publications

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“…The role of MINCR has been studied in some types of cancer, where it has been found to inhibit the activity of some miRNAs through the ceRNA function [ 24 , 28 , 29 , 30 ]. For example, in bladder cancer cells, MINCR regulates the expression of EZH2 through miR-26a-5p, while silencing MINCR decreases cell proliferation and invasion and increases apoptosis [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

The E6 Oncoprotein of HPV16 AA-c Variant Regulates Cell Migration through the MINCR/miR-28-5p/RAP1B Axis

Perez-Bacho

Beltrán-Anaya

Aréchaga-Ocampo

et al. 2022

Viruses

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The E6 oncoprotein of HPV16 variants differentially alters the transcription of the genes involved in migration and non-coding RNAs such as lncRNAs. The role of the lncRNA MINCR in cervical cancer and its relationship with variants of oncogenic HPV remain unknown. Therefore, the objective of this study was to analyze the effect of the E6 oncoprotein of the AA-c variant of HPV16 in cell migration through the MINCR/miR-28-5p/RAP1B axis. To explore the functional role of MINCR in CC, we used an in vitro model of C33-A cells with exogenous expression of the E6 oncoprotein of the AA-c variant of HPV16. Interfering RNAs performed MINCR silencing, and the expression of miR-28-5p and RAP1B mRNA was analyzed by RT-qPCR. We found that C33-A/AA-c cells expressed MINCR 8-fold higher compared to the control cells. There is an inverse correlation between the expression of miR-28-5p and RAP1B in C33-A/AA-c cells. Our results suggest that MINCR might regulate the expression of RAP1B through the inhibition of miR-28-5p in CC cells expressing the E6 oncoprotein of HPV16 AA-c. We report, for the first time, that the MINCR/miR-28-5p/RAP1B axis positively regulates cell migration in CC-derived cells that express the E6 oncoprotein of the AA-c variant of HPV16.

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Section: Discussionmentioning

confidence: 99%

The E6 Oncoprotein of HPV16 AA-c Variant Regulates Cell Migration through the MINCR/miR-28-5p/RAP1B Axis

Perez-Bacho

Beltrán-Anaya

Aréchaga-Ocampo

et al. 2022

Viruses

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“…To our knowledge, the association of the other six key lncRNAs ( MINCR , LINC01094 , DLGAP1-AS1 , BABAM2-AS1 , PAX8-AS1 , and ZFHX4-AS1 ) has not been the specific focus of investigations in the context of mental disorders. MINCR is a Myc-induced lncRNA related to some cancers via acting as a ceRNA 59 . Similarly, recent studies report that LINC01094 60 , DLGAP1-AS1 61 , and PAX8-AS1 62 can act as a ceRNA in some cancers.…”

Section: Discussionmentioning

confidence: 99%

Bioinformatics analysis of long non-coding RNA-associated competing endogenous RNA network in schizophrenia

Sabaie

Moghaddam

et al. 2021

Sci Rep

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Schizophrenia (SCZ) is a serious psychiatric condition with a 1% lifetime risk. SCZ is one of the top ten global causes of disabilities. Despite numerous attempts to understand the function of genetic factors in SCZ development, genetic components in SCZ pathophysiology remain unknown. The competing endogenous RNA (ceRNA) network has been demonstrated to be involved in the development of many kinds of diseases. The ceRNA hypothesis states that cross-talks between coding and non-coding RNAs, including long non-coding RNAs (lncRNAs), via miRNA complementary sequences known as miRNA response elements, creates a large regulatory network across the transcriptome. In the present study, we developed a lncRNA-related ceRNA network to elucidate molecular regulatory mechanisms involved in SCZ. Microarray datasets associated with brain regions (GSE53987) and lymphoblasts (LBs) derived from peripheral blood (sample set B from GSE73129) of SCZ patients and control subjects containing information about both mRNAs and lncRNAs were downloaded from the Gene Expression Omnibus database. The GSE53987 comprised 48 brain samples taken from SCZ patients (15 HPC: hippocampus, 15 BA46: Brodmann area 46, 18 STR: striatum) and 55 brain samples taken from control subjects (18 HPC, 19 BA46, 18 STR). The sample set B of GSE73129 comprised 30 LB samples (15 patients with SCZ and 15 controls). Differentially expressed mRNAs (DEmRNAs) and lncRNAs (DElncRNAs) were identified using the limma package of the R software. Using DIANA-LncBase, Human MicroRNA Disease Database (HMDD), and miRTarBase, the lncRNA- associated ceRNA network was generated. Pathway enrichment of DEmRNAs was performed using the Enrichr tool. We developed a protein–protein interaction network of DEmRNAs and identified the top five hub genes by the use of STRING and Cytoscape, respectively. Eventually, the hub genes, DElncRNAs, and predictive miRNAs were chosen to reconstruct the subceRNA networks. Our bioinformatics analysis showed that twelve key DEmRNAs, including BDNF, VEGFA, FGF2, FOS, CD44, SOX2, NRAS, SPARC, ZFP36, FGG, ELAVL1, and STARD13, participate in the ceRNA network in SCZ. We also identified DLX6-AS1, NEAT1, MINCR, LINC01094, DLGAP1-AS1, BABAM2-AS1, PAX8-AS1, ZFHX4-AS1, XIST, and MALAT1 as key DElncRNAs regulating the genes mentioned above. Furthermore, expression of 15 DEmRNAs (e.g., ADM and HLA-DRB1) and one DElncRNA (XIST) were changed in both the brain and LB, suggesting that they could be regarded as candidates for future biomarker studies. The study indicated that ceRNAs could be research candidates for investigating SCZ molecular pathways.

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“…Many studies have shown that the above LncRNAs are specific in the development of cancer.For example, in the current investigation, LINC01096 was not shown to be predictive for ovarian cancer but was found to be significantly expressed in breast cancer tissue cells, and knocking down LINC01096 prevented [ 28 ] cancer cell migration and invasion. DNM3OS was overexpressed in ovarian cancer, and knockdown of it similarly inhibited migration and invasion of cancer cells and reduced mesenchymal to epithelial transformation [29].USP30-AS1 inhibits apoptosis in acute myeloid leukemia cells and may promote cancer cell survival through cis-regulation of USP30 and ANKRD13A [30]. By serving as a competitive endogenous RNA, MINCR may increase glioma cell proliferation and migration [31].…”

Section: Discussionmentioning

confidence: 99%

Necroptosis-associated LncRNA markers for late survival prediction, immune and gene mutation analysis in ovarian cancer

Fan

et al. 2022

Preprint

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OBJECTIVE To investigate the potential prognostic value of necroptosis-associated lncRNAs (NALncRNAs)in patients with ovarian cancer. METHODS Gene expression data from ovarian cancer patients with clinical data were downloaded from TCGA database. This is the base data for screening NALncRNAs that represent different survival times.lncRNA risk models were constructed by Cox regression analysis and evaluated for their prognostic value. The link between lncRNA signatures and related pathways, immune cell activity, immunological checkpoints, m6A-related genes, and gene mutations was also investigated. RESULTS In this study, eight NALncRNAs including USP30-AS1, MINCR, LINC01096, DNM3OS, LINC02574, DTNB-AS1, ACAP2-IT1, and ILVBL-AS1, all of which were well represented for the outcome of ovarian cancer patients. Noemogram after calibration curve validation has good clinical utility. Risk signatures were shown to be abundant in various pathways related to immunology and cell proliferation, according to gene set enrichment analysis. Patients' late survival outcome corresponds to differences in immune cells, immune checkpoints, immune function, etc.A better immune microenvironment would facilitate late survival, but inexplicably patients with long survival times have a higher immune escape. Patients with high mutations in genes appear to have better survival outcomes. CONCLUSION This study identified eight NALncRNAs markers for the first time, providing a valuable basis for more accurate prediction of ovarian cancer prognosis.

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Long Non-coding RNA MINCR Regulates miR-876-5p/GSPT1 Axis to Aggravate Glioma Progression

Cited by 17 publications

References 35 publications

The E6 Oncoprotein of HPV16 AA-c Variant Regulates Cell Migration through the MINCR/miR-28-5p/RAP1B Axis

The E6 Oncoprotein of HPV16 AA-c Variant Regulates Cell Migration through the MINCR/miR-28-5p/RAP1B Axis

Bioinformatics analysis of long non-coding RNA-associated competing endogenous RNA network in schizophrenia

Necroptosis-associated LncRNA markers for late survival prediction, immune and gene mutation analysis in ovarian cancer

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