“…These results are consistent with those reported in other studies. In addition, mauer et al reported that IL-6 signalling promotes macrophage M2 polarization to reduce pronounced inflammation and insulin resistance, and identified IL-6 signalling as an important determinant of macrophage M2 polarization [ 40 , 41 ]. Hence, the regulation of macrophage M2-type polarization by Mg–Ca/nHAC biomaterials may involve a more intricate process that needs to be explored in the future.…”