Long non-coding RNA (lncRNA) HOXB-AS3 promotes cell proliferation and inhibits apoptosis by regulating ADAM9 expression through targeting miR-498-5p in endometrial carcinoma

Xing, Ying; Sun, Xiangrong; Li, Feng; Jiang, Xuan; Jiang, Afang; Li, Xiaofan; Lv, Ruiting; Shao, Liwei

doi:10.1177/03000605211013548

Cited by 9 publications

(15 citation statements)

References 39 publications

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“…For example, Li et al [ 15 ] demonstrated that lnc-MONC restrains the grade malignancy of endometrial cancer stem cells (ECSCs) and endometrial cancer cells (ECCs) by ordering the miR-636/GLCE axis. Similarly, lncRNA HOXB-AS3 was upregulated in endometrial cancer tissues and cell lines, enhanced cell proliferation, and inhibited apoptosis in EC cells [ 16 ]. Therefore, lncRNAs exhibit a novel potential therapeutic aim for EC.…”

Section: Introductionmentioning

confidence: 99%

lncRNA NBAT1 Inhibits Cell Metastasis and Promotes Apoptosis in Endometrial Cancer by Sponging miR-21-5p to Regulate PTEN

Tian

et al. 2022

Computational and Mathematical Methods in Medicine

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Objective. Long noncoding RNA neuroblastoma-associated transcript 1 (NBAT1) is implicated in the progression of various cancers. Nevertheless, its biological function in endometrial cancer (EC) remains unknown. Methods. The levels of NBAT1, miR-21-5p, and PTEN in EC cells and EC tissues were examined by RT-qPCR. Western blot was carried out to assess the protein expression of PTEN. The dual-luciferase reporter assay was conducted to explore the interactions among NBAT1, miR-21-5p, and PTEN. The effect of NBAT1 on EC proliferation, metastasis, and apoptosis was evaluated by CCK-8, transwell assays, wound healing, and flow cytometry. miR-21-5p mimics or NBAT1+miR-21-5p were transfected into HEC-1A and Ishikawa cells to investigate whether NBAT1 regulated EC tumorigenesis via sponging miR-21-5p. Results. NBAT1 is downregulated, and miR-21-5p is upregulated in EC cells and tumor tissues. Overexpression of NBAT1 inhibits the proliferation, migration, and invasion abilities of EC cells and facilitated apoptosis. NBAT1 directly binds and negatively regulates miR-21-5p in EC. miR-21-5p mimics reverses the effect of lncRNA NBAT1 overexpression on the proliferation and migration of EC cells. PTEN is a downstream gene of miR-21-5p. lncRNA NBTA1 elevates PTEN expression via sponging miR-21-5p. Conclusions. lncRNA NBAT1 acts as a tumor suppressor in EC via regulating PTEN through sponging miR-21-5p.

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Section: Introductionmentioning

confidence: 99%

lncRNA NBAT1 Inhibits Cell Metastasis and Promotes Apoptosis in Endometrial Cancer by Sponging miR-21-5p to Regulate PTEN

Tian

et al. 2022

Computational and Mathematical Methods in Medicine

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“…In recent studies, aberrant expression of the HOXB-AS3 RNA has been found in liver cancer 47 , 49 , lung cancer 43 , ovarian cancer 41 , 44 , endometrial cancer 42 , 48 , 51 , and acute myeloid leukemia 45 , 46 , 50 . And at the protein expression level, abnormal expression of the HOXB-AS3 micro-peptide has been reported in oral squamous cell carcinoma 52 and colon cancer 40 ( Table 1 ).…”

Section: Promising Clinical Biomarker In Human Cancermentioning

confidence: 99%

“…This upregulation enhances tumor cell proliferation while inhibiting apoptosis. Similarly, in endometrial carcinoma (EC) 42 , both cancer tissues and EC cell lines exhibit overexpression of lncRNA HOXB-AS3, and lncRNA HOXB-AS3 correlates with survival rates in EC patients. HOXB-AS3 overexpression could promote EC progression 42 .…”

Section: Introductionmentioning

confidence: 99%

A concise review of the regulatory, diagnostic, and prognostic implications of HOXB-AS3 in tumors

Wu,

Ye,

Zhang

et al. 2024

J. Cancer

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Recent studies have reported that HOXB-AS3 (HOXB Cluster Antisense RNA 3) is an intriguing molecule with dual functionality as a long noncoding RNA (lncRNA) and putative coding peptide in tumorigenesis and progression. The significant expression alterations of HOXB-AS3 were detected in diverse cancer types and closely correlated with clinical stage and patient survival. Furthermore, HOXB-AS3 was involved in a spectrum of biological processes in solid tumors and hematological malignancies, such as stemness, lipid metabolism, migration, invasion, and tumor growth. This review comprehensively analyzes its clinical relevance for diagnosis and prognosis across human tumors and summarizes its functional role and regulatory mechanisms in different malignant tumors, including liver cancer, acute myeloid leukemia, ovarian cancer, lung cancer, endometrial carcinoma, colon cancer, and oral squamous cell carcinoma. Overall, HOXB-AS3 emerges as a promising biomarker and novel therapeutic target in multiple human tumors.

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“…For example, lncRNA HOXB-AS3 inhibits colon cancer (cancer cell colony formation, proliferation, migration, and invasion) through encoding a 53 amino acids (aa) peptide but not lncRNA itself (33). In endometrial carcinoma (EC) cells, this lncRNA binds to the tumorsuppressing miR-598-5p through sequence annealing and downregulates its level, which in turn, leads to enhanced cancer cell proliferation (34).…”

Section: General Biology Of Lncrnamentioning

confidence: 99%

Emerging Roles of lncRNAs Regulating RNA-Mediated Type-I Interferon Signaling Pathway

Wang

Liu

et al. 2022

Front. Immunol.

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The type-I interferon (IFN-I) signaling pathway plays pivot roles in defending against pathogen invasion. Exogenous ssRNA and dsRNA could be immunogenic. RNA-mediated IFN signaling is extensively studied in the field. The incorrect functioning of this pathway leads to either autoimmune diseases or suffering from microorganism invasion. From the discrimination of “self” and “non-self” molecules by receptors to the fine-tune modulations in downstream cascades, all steps are under the surveillance featured by complex feedbacks and regulators. Studies in recent years highlighted the emerging roles of long noncoding RNAs (lncRNAs) as a reservoir for signaling regulation. LncRNAs bind to targets through the structure and sequence, and thus the mechanisms of action can be complex and specific. Here, we summarized lncRNAs modulating the RNA-activated IFN-I signaling pathway according to the event order during the signaling. We hope this review help understand how lncRNAs are participating in the regulation of IFN-I signaling.

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Long non-coding RNA (lncRNA) HOXB-AS3 promotes cell proliferation and inhibits apoptosis by regulating ADAM9 expression through targeting miR-498-5p in endometrial carcinoma

Cited by 9 publications

References 39 publications

lncRNA NBAT1 Inhibits Cell Metastasis and Promotes Apoptosis in Endometrial Cancer by Sponging miR-21-5p to Regulate PTEN

lncRNA NBAT1 Inhibits Cell Metastasis and Promotes Apoptosis in Endometrial Cancer by Sponging miR-21-5p to Regulate PTEN

A concise review of the regulatory, diagnostic, and prognostic implications of HOXB-AS3 in tumors

Emerging Roles of lncRNAs Regulating RNA-Mediated Type-I Interferon Signaling Pathway

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