Long non‐coding RNA LEF1‐AS1 is involved in the progression of retinoblastoma through regulating the Wnt/β‐catenin pathway

He, Hua; Qin, Mu

doi:10.1111/1440-1681.13263

Cited by 15 publications

(10 citation statements)

References 25 publications

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“…Several studies have demonstrated that lncRNAs exert pivotal functions in retinoblastoma via acting as tumor suppressors or oncogenes. [10][11][12] High expression in hepatocellular carcinoma (HEIH), also known as hepatocellular carcinoma up-regulated EZH2-associated long non-coding RNA, is a recently identified intergenic lncRNA located in chromosome chr5:-180256954-180258618. HEIH was firstly characterized to be overexpressed in HBV-related hepatocellular carcinoma tissues compared with paired peritumoral tissues.…”

Section: Introductionmentioning

confidence: 99%

<p>Long Noncoding RNA HEIH Promotes Proliferation, Migration and Invasion of Retinoblastoma Cells Through miR-194-5p/WEE1 Axis</p>

Gao¹,

Chu²,

Liu³

et al. 2020

OTT

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Background: Abnormally expressed long noncoding RNA (lncRNA) high expression in hepatocellular carcinoma (HEIH) has been implicated in many types of human cancer, and plays crucial roles in tumor development and progression. However, little is known about its function in retinoblastoma. Methods: qRT-PCR was used to determine the expression levels of HEIH, miR-194-5p and WEE1 in retinoblastoma tissues and cell lines. The trypan blue exclusion method, colony formation assay, wound-healing assay and transwell invasion assay were performed to evaluate the effects of HEIH, miR-194-5p and WEE1 on cell proliferation, migration and invasion. Bioinformatics analysis, dual-luciferase reporter assay and Western blot were employed to investigate the regulatory relationship among HEIH, miR-194-5p and WEE1. Results: We found that HEIH was up-regulated in retinoblastoma tissues and cell lines. Furthermore, high level of HEIH was associated with TNM stage, optic nerve invasion and choroidal invasion of patients with retinoblastoma. Functional studies showed that HEIH knockdown significantly suppressed retinoblastoma cell proliferation, migration and invasion. Mechanistically, HEIH promoted retinoblastoma progression by serving as a sponge of miR-194-5p to regulate WEE1 expression. Conclusion: Our work suggests that HEIH acts as an oncogenic lncRNA to promote retinoblastoma proliferation and metastasis, providing a new insight into the retinoblastoma treatment.

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Section: Introductionmentioning

confidence: 99%

<p>Long Noncoding RNA HEIH Promotes Proliferation, Migration and Invasion of Retinoblastoma Cells Through miR-194-5p/WEE1 Axis</p>

Gao¹,

Chu²,

Liu³

et al. 2020

OTT

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“… 23 In glioblastoma tissues, LEF1‐AS1 was highly expressed and elevated cell malignant behaviors by sponging miR‐543 to upregulate the expression of EN2. 24 LEF1‐AS1 was also overexpressed and functioned as an oncogene in hepatocellular carcinoma, 25 ovarian cancer, 26 retinoblastoma, 27 osteosarcoma, 28 esophageal squamous cell carcinoma, 29 non‐small‐cell lung cancer, 30 oral squamous cell carcinoma, 31 and prostate cancer, 32 while in myeloid malignancy, LEF1‐AS1 was downregulated and served as a tumor suppressor lncRNA. 33 LINC01224 in our signature has also been used to establish a risk model for predicting BC patients’ prognosis in a previous study.…”

Section: Discussionmentioning

confidence: 99%

Development of a novel five‐lncRNA prognostic signature for predicting overall survival in elderly patients with breast cancer

Luo

Zhang

et al. 2021

Clinical Laboratory Analysis

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Background Breast cancer (BC) is an age‐related disease. Long noncoding RNAs (lncRNAs) have been proven to be crucial contributors in tumorigenesis. This study aims to develop a novel lncRNA‐based signature to predict elderly BC patients’ prognosis. Methods The RNA expression profiles and corresponding clinical information of 182 elderly BC patients were retrieved from The Cancer Genome Atlas (TCGA). Differentially expressed lncRNAs (DElncRNAs) between BC and adjacent normal samples were used to construct the signature in the training set through univariate Cox regression analysis, LASSO regression analysis, and multivariate Cox regression analysis. Kaplan–Meier analysis and time‐dependent receiver operating characteristic (ROC) analysis were used to evaluate the predictive performance. Besides, we developed the nomogram. Gene set enrichment analysis (GSEA) was performed to reveal the underlying molecular mechanisms. Results We constructed the five‐lncRNA signature (including LEF1‐AS1, MEF2C‐AS1, ST8SIA6‐AS1, LINC01224, and LINC02408) in the training set, which successfully divided the patients into low‐ and high‐risk groups with significantly different prognosis (p = 0.000049), and the AUC at 3 and 5 years of the signature was 0.779 and 0.788, respectively. The predictive performance of this signature was validated in the test and entire set. The 5‐lncRNA signature was an independent prognostic factor of OS (p = 0.007) and the nomogram constructed by independent prognostic factors was an accurate predictor of predicting overall survival probability. Besides, several pathways associated with tumorigenesis have been identified by GSEA. Conclusions The 5‐lncRNA signature and nomogram are reliable in predicting elderly BC patients’ prognosis and provide clues for clinical decision‐making.

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“…Li and his colleagues pointed out that LEF1-AS1 promotes the metastasis of prostatic carcinoma through the Wnt/β-catenin pathway (Li W. et al, 2020). Similarly, He et al (He and Qin, 2020) found that silent LEF1-AS1 inhibited the biological function of retinoblastoma cells by inhibiting the expressions of β-catenin and LEF1. The Wnt/β-catenin pathway has also been confirmed to be involved in the occurrence and progression of osteosarcoma (Lu et al, 2020) and colorectal cancer (Qi et al, 2021).…”

Section: Wnt/β-catenin Pathwaymentioning

confidence: 97%

“…Certain studies reported a significant overexpression of LEF1-AS1 in osteosarcoma, prostate cancer, and retinoblastoma (Liu et al, 2019;Li W. et al, 2020;He and Qin, 2020;Lu et al, 2020). He et al pointed out that high expression of LEF1-AS1 predicted poor prognosis in retinoblastoma.…”

Section: Other Cancersmentioning

confidence: 99%

“…In lung cancer (Wang et al, 2019), osteosarcoma (Lu et al, 2020) and retinoblastoma (He and Qin, 2020), it has been reported that LEF1-AS1 is an upregulated oncogene promoting tumor progression. One study on ovarian cancer showed that the downregulation of LEF1-AS1 gene inhibited the proliferation, migration, and invasion of ovarian cancer cells.…”

Section: Other Cancersmentioning

confidence: 99%

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Current Research Progress of the Role of LncRNA LEF1-AS1 in a Variety of Tumors

Zheng¹,

Yu²,

Zhang³

et al. 2021

Front. Cell Dev. Biol.

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Long non-coding RNAs (lncRNA), as key regulators of cell proliferation and death, are involved in the regulation of various processes in the nucleus and cytoplasm, involving biological developmental processes in the fields of immunology, neurobiology, cancer, and stress. There is great scientific interest in exploring the relationship between lncRNA and tumors. Many researches revealed that lymph enhancer-binding factor 1-antisense RNA 1 (LEF1-AS1), a recently discovered lncRNA, is downregulated in myeloid malignancy, acting mainly as a tumor suppressor, while it is highly expressed and carcinogenic in glioblastoma (GBM), lung cancer, hepatocellular carcinoma (HCC), osteosarcoma, colorectal cancer (CRC), oral squamous cell carcinoma (OSCC), prostatic carcinoma, retinoblastoma, and other malignant tumors. Furthermore, abnormal LEF1-AS1 expression was associated with tumorigenesis, development, survival, and prognosis via the regulation of target genes and signaling pathways. This review summarizes the existing data on the expression, functions, underlying mechanism, relevant signaling pathways, and clinical significance of LEF1-AS1 in cancer. It is concluded that LEF1-AS1 can serve as a novel biomarker for the diagnosis and prognosis of various tumors, thus deserves further attention in the future.

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Long non‐coding RNA LEF1‐AS1 is involved in the progression of retinoblastoma through regulating the Wnt/β‐catenin pathway

Cited by 15 publications

References 25 publications

<p>Long Noncoding RNA HEIH Promotes Proliferation, Migration and Invasion of Retinoblastoma Cells Through miR-194-5p/WEE1 Axis</p>

<p>Long Noncoding RNA HEIH Promotes Proliferation, Migration and Invasion of Retinoblastoma Cells Through miR-194-5p/WEE1 Axis</p>

Development of a novel five‐lncRNA prognostic signature for predicting overall survival in elderly patients with breast cancer

Current Research Progress of the Role of LncRNA LEF1-AS1 in a Variety of Tumors

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