Long non-coding RNA in stem cell pluripotency and lineage commitment: functions and evolutionary conservation

Fico, Annalisa; Fiorenzano, Alessandro; Pascale, Emilia; Patriarca, Eduardo J.; Minchiotti, Gabriella

doi:10.1007/s00018-018-3000-z

Cited by 80 publications

(70 citation statements)

References 128 publications

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“…MiRNAs directly affect HIF-1α expression and activity, while others may have indirect regulations. LncRNAs have diverse regulatory functions, which can modulate chromatin remodeling, transcriptional regulation, posttranscriptional processing, and translation [98,99]. Emerging reports have suggested the function of lncRNAs as competing endogenous RNAs (ceRNAs) for miRNAs to regulate related mRNA expression at the posttranscriptional level [100], including HIF-1α mRNA.…”

Section: Regulation Of Hif-1α Expression By Ncrnasmentioning

confidence: 99%

The interplay between HIF-1α and noncoding RNAs in cancer

Peng

Han

et al. 2020

J Exp Clin Cancer Res

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Hypoxia is a classic characteristic of the tumor microenvironment with a significant impact on cancer progression and therapeutic response. Hypoxia-inducible factor-1 alpha (HIF-1α), the most important transcriptional regulator in the response to hypoxia, has been demonstrated to significantly modulate hypoxic gene expression and signaling transduction networks. In past few decades, growing numbers of studies have revealed the importance of noncoding RNAs (ncRNAs) in hypoxic tumor regions. These hypoxia-responsive ncRNAs (HRNs) play pivotal roles in regulating hypoxic gene expression at the transcriptional, posttranscriptional, translational and posttranslational levels. In addition, as a significant gene expression regulator, ncRNAs exhibit promising roles in regulating HIF-1α expression at multiple levels. In this review, we briefly elucidate the reciprocal regulation between HIF-1α and ncRNAs, as well as their effect on cancer cell behaviors. We also try to summarize the complex feedback loop existing between these two components. Moreover, we evaluated the biomarker potential of HRNs for the diagnosis and prognosis of cancer, as well as the potential clinical utility of shared regulatory mechanisms between HIF-1α and ncRNAs in cancer treatment, providing novel insights into tumorigenicity, which may lead to innovative clinical applications.

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Section: Regulation Of Hif-1α Expression By Ncrnasmentioning

confidence: 99%

The interplay between HIF-1α and noncoding RNAs in cancer

Peng

Han

et al. 2020

J Exp Clin Cancer Res

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“…ChIP-Seq was performed to generate a database to illustrate the relationship between transcription factors and lncRNAs in pluripotency regulation (Yang et al, 2013). Most lncRNAs were regulated by key pluripotent transcription factors, including Oct4, Sox2 and Nanog (Ng et al, 2012;Fico et al, 2019). Recently, Du and coauthors identified multiple pluripotency-associated lncRNAs embedded in the chromatin regulatory network by combining RNA-Seq and RAT-seq (Du et al, 2018).…”

Section: The Role Of Lncrna In Stem Cell Pluripotencymentioning

confidence: 99%

LncRNA Functions as a New Emerging Epigenetic Factor in Determining the Fate of Stem Cells

Chen

Wang

et al. 2020

Front. Genet.

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Pluripotent stem cells have broad applications in regenerative medicine and offer ideal models for understanding the biological process of embryonic development and specific diseases. Studies suggest that the self-renewal and multi-lineage differentiation of stem cells are regulated by a complex network consisting of transcription factors, chromatin regulators, signaling factors, and non-coding RNAs. It is of great interest to identify RNA regulatory factors that determine the fate of stem cells. Long non-coding RNA (lncRNA), a class of non-coding RNAs with more than 200 bp in length, has been shown to act as essential epigenetic regulators of stem cell pluripotency and specific lineage commitment. In this review, we focus on recent research progress related to the function and epigenetic mechanisms of lncRNA in determining the fate of stem cells, particularly pluripotency maintenance and lineage-specific differentiation. We discuss the role of the Oct4 and Sox2 promoter-interacting lncRNA as identified by Chromatin RNA In Situ reverse Transcription sequencing (CRIST-seq). Further understanding of their potential actions will provide a basis for the development of regenerative medicine for clinical application. This work offers comprehensive details and better understanding of the role of lncRNA in determining the fate of stem cells and paves the way for clinical stem cell applications.

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“…Long ncRNAs have diversity of regulatory functions, which can modulate chromatin remodelling, transcriptional regulation and post‐transcriptional processing, translation 74,75 . Although multiple functions of lncRNAs have been observed, competing endogenous RNA (ceRNA) or miRNA sponge is the most focused function.…”

Section: Long Non‐coding Rnasmentioning

confidence: 99%

Systematic characterization of non‐coding RNAs in triple‐negative breast cancer

et al. 2020

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Triple‐negative breast cancer (TNBC) is one of the most aggressive subtypes of breast cancer with negativity for oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor (HER2). Non‐coding RNAs (ncRNAs) make up most of the transcriptome and are widely present in eukaryotic cells. In recent years, emerging evidence suggests that ncRNAs, mainly microRNAs (miRNAs), long ncRNAs (lncRNAs) and circular RNAs (circRNAs), play prominent roles in the tumorigenesis and development of TNBC, but the functions of most ncRNAs have not been fully described. In this review, we systematically elucidate the general characteristics and biogenesis of miRNAs, lncRNAs and circRNAs, discuss the emerging functions of these ncRNAs in TNBC and present future perspectives in clinical practice.

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Long non-coding RNA in stem cell pluripotency and lineage commitment: functions and evolutionary conservation

Cited by 80 publications

References 128 publications

The interplay between HIF-1α and noncoding RNAs in cancer

The interplay between HIF-1α and noncoding RNAs in cancer

LncRNA Functions as a New Emerging Epigenetic Factor in Determining the Fate of Stem Cells

Systematic characterization of non‐coding RNAs in triple‐negative breast cancer

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