Long non-coding RNA in lung cancer

Chen, Zhenyao; Lei, Tianyao; Chen, Xin; Gu, Jianqin; Huang, Jiana; Lu, Binfeng; Wang, Zhaoxia

doi:10.1016/j.cca.2019.11.031

Cited by 51 publications

(46 citation statements)

References 140 publications

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“…Another non-coding RNA that has a key role in lung tumorigenesis and metastasis is long non-coding RNA (lncRNA). Unlike miRNAs, lncRNAs manifest themselves in lung cancer by regulating gene expression not only at the post-transcriptional level, but also at the transcriptional and epigenetic level [79]. It is important to note that lncRNAs and miRNAs are able to interact with each other, evidenced by the ability of lncRNAs to act as miRNA sponges, where lncRNAs can increase or decrease miRNAs effect on mRNA by outcompeting substrates that traditionally bind to miRNAs [80].…”

Section: Non-coding Rna Network In Lung Cancermentioning

confidence: 99%

Non-Coding RNAs in Lung Tumor Initiation and Progression

Santos

Moreno

Zhang

2020

IJMS

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Lung cancer is one of the deadliest forms of cancer affecting society today. Non-coding RNAs, such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), through the transcriptional, post-transcriptional, and epigenetic changes they impose, have been found to be dysregulated to affect lung cancer tumorigenesis and metastasis. This review will briefly summarize hallmarks involved in lung cancer initiation and progression. For initiation, these hallmarks include tumor initiating cells, immortalization, activation of oncogenes and inactivation of tumor suppressors. Hallmarks involved in lung cancer progression include metastasis and drug tolerance and resistance. The targeting of these hallmarks with non-coding RNAs can affect vital metabolic and cell signaling pathways, which as a result can potentially have a role in cancerous and pathological processes. By further understanding non-coding RNAs, researchers can work towards diagnoses and treatments to improve early detection and clinical response.

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Section: Non-coding Rna Network In Lung Cancermentioning

confidence: 99%

Non-Coding RNAs in Lung Tumor Initiation and Progression

Santos

Moreno

Zhang

2020

IJMS

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“…5 The effects of lncRNAs on the occurrence and development of cancer is a research hotspot, and many studies have shown that lncRNAs can affect multiple stages of tumor progression such as invasion, metastasis, prognosis. [6][7][8] LncRNAs also play an essential role in EC by affecting its development, diagnosis and treatment. 9,10 MicroRNAs (miRNAs) are another class of non-coding RNAs.…”

Section: Introductionmentioning

confidence: 99%

<p>LncRNA SNHG6 Inhibits Apoptosis by Regulating EZH2 Expression via the Sponging of MiR-101-3p in Esophageal Squamous-Cell Carcinoma</p>

Wang

Yang

et al. 2020

OTT

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Background: The long non-coding RNA (lncRNA) SNHG6 was significantly upregulated in esophageal squamous-cell carcinoma (ESCC), and it promoted ESCC cell proliferation, invasion, and migration. However, the effects of SNHG6 on cell apoptosis and the corresponding underlying mechanisms have not yet reported. Methods: Apoptosis was detected by flow cytometric analysis. Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting were used for mRNA and protein quantification, respectively. A luciferase reporter assay was performed to verify downstream target genes for SNHG6 and miR-101-3p. Results: Dysregulation of SNHG6 inhibited apoptosis in ESCC cells and regulated the expression of apoptosis-related proteins such as Bcl-2, Mcl-1, Bax and Caspase-3. Functionally, miR-101-3p could compete binding with 3′-untranslated region of SNHG6 and downregulation of miR-101-3p reversed its effect on cell apoptosis in SNHG6 knockdown cells. EZH2 was confirmed as a downstream target gene of miR-101-3p, silencing EZH2 expression had the same effect on apoptosis and protein expression as knocking down SNHG6. Overexpression of EZH2 reversed the effects of miR-101-3p overexpression on cell apoptosis in ESCC cells. Conclusion: In this study, we found that upregulation of the lncRNA SNHG6 inhibited apoptosis via miR-101-3p/EZH2 axis in ESCC. These findings may contribute to the diagnosis and treatment of ESCC.

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“…Among these non-coding genes, long non-coding RNAs (lncRNAs) are emerging as a new class of indispensable players involved in the tumorigenesis [ 3 , 5 , 6 ]. Moreover, the dysregulation of a number of lncRNA targets has been reported to associate with the stage and prognosis of many tumor types [ 7 , 8 ] including breast cancer [ 9 , 10 ], lung cancer [ 11 , 12 ], and liver cancer [ 13 , 14 ], as well as linked to resistance against chemotherapy and targeted therapy [ 15 , 16 ]. For example, the overexpression of the lncRNAHOX transcript antisense intergenic RNA(HOTAIR) promotes the metastasis of breast cancer cells [ 17 ].…”

Section: Identifying Lncrnas In Cancermentioning

confidence: 99%

LncRNAs as tumor cell intrinsic factors that affect cancer immunotherapy

Egranov

Lin

et al. 2020

RNA Biology

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Long noncoding RNAs (lncRNAs) have been found to associate with all major types of malignancies and play important roles in regulating several hallmarks of cancer by interacting with proteins, DNA, and RNA. The possible functions of lncRNAs and their roles in the regulation of tumour growth will be reported and discussed in the present review. In our recent report, based on genetic mice models and a series of systematic analyses, we suggested that lncRNAs also play critical roles in the regulation of antigen presentation in tumour cells and allow tumour cells to escape immune surveillance, which further broadens the scope of understanding lncRNA functions and how they relate to cancer immunotherapy resistance.

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Long non-coding RNA in lung cancer

Cited by 51 publications

References 140 publications

Non-Coding RNAs in Lung Tumor Initiation and Progression

Non-Coding RNAs in Lung Tumor Initiation and Progression

<p>LncRNA SNHG6 Inhibits Apoptosis by Regulating EZH2 Expression via the Sponging of MiR-101-3p in Esophageal Squamous-Cell Carcinoma</p>

LncRNAs as tumor cell intrinsic factors that affect cancer immunotherapy

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