Long non-coding RNA HOTAIR is a powerful predictor of metastasis and poor prognosis and is associated with epithelial-mesenchymal transition in colon cancer

Wu, Zehua; Wang, Xiaoliang; Tang, Huamei; Jiang, Tao; Chen, Jian; Lu, Su; Qiu, Guoqiang; Peng, Zhihai; Yan, Dongwang

doi:10.3892/or.2014.3186

Cited by 190 publications

(155 citation statements)

References 24 publications

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“…The 3' end of HOTAIR interacts with lysine-specific histone demethylase 1A (22). Furthermore, recent studies have reported that HOTAIR is highly expressed and associated with poor prognosis in a number of types of cancer, including breast cancer, epithelial ovarian cancer, pancreatic cancer, colorectal cancer, non-small-cell lung cancer and endometrial carcinoma (21,(23)(24)(25)(26)(27).…”

Section: Introductionmentioning

confidence: 99%

Long non-coding RNA HOTAIR is a marker for hepatocellular carcinoma progression and tumor recurrence

Jianzhi

et al. 2016

Oncology Letters

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Abstract. The present study aimed to investigate the expression level of HOX transcript antisense RNA (HOTAIR) in hepatocellular carcinoma (HCC) and its association with various clinicopathological characteristics, and to further explore the molecular mechanisms of HOTAIR function in HCC. Quantitative reverse transcription-polymerase chain reaction (RT-PCR) was used to detect the expression level of HOTAIR in 60 paired fresh HCC samples and adjacent normal liver tissue samples. The association between HOTAIR expression and clinicopathological parameters was analyzed. Lentivirus-mediated HOTAIR-specific small hairpin RNA vectors were transfected into HepG2 cells. Cell proliferation and invasion in vitro were examined by MTT and Transwell assays, respectively. A xenograft model was used to analyze the tumorigenesis of liver cancer cells in vivo. In addition, semi-quantitative RT-PCR was used to detect the expression level of Wnt/β-catenin signaling molecules under the condition of HOTAIR inhibition. The results revealed that the expression level of HOTAIR in HCC tissues was higher than that in adjacent non-cancerous tissues. HOTAIR expression was significantly associated with poor tumor differentiation (P=0.002), metastasis (P=0.002) and early recurrence (P=0.001). In vitro, the inhibition of HOTAIR in liver cancer cells resulted in the suppression of cell proliferation and invasion. HOTAIR depletion significantly inhibited the rate of growth of liver cancer cells in vivo. Furthermore, the expression levels of Wnt and β-catenin were downregulated when HOTAIR expression was suppressed. In conclusion, HOTAIR is important in the progression and recurrence of HCC, partly through the regulation of the Wnt/β-catenin signaling pathway. Targeting HOTAIR may be a novel therapeutic strategy for HCC.

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Section: Introductionmentioning

confidence: 99%

Long non-coding RNA HOTAIR is a marker for hepatocellular carcinoma progression and tumor recurrence

Jianzhi

et al. 2016

Oncology Letters

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“…Colon cancer patients with high HOTAIR expression had higher recurrence rates and reduced metastasis-free and overall survival compared with those with low HOTAIR expression. Further investigation revealed that HOTAIR increased the expression of E-cadherin and decreased the expression of vimentin and MMP9 [75]. Svoboda et al demonstrated that HOTAIR expression was increased in primary tumors and blood of CRC patients, and its levels in tumors were associated with higher mortality of patients, suggesting that HOTAIR blood levels might serve as a potential surrogate prognostic marker in sporadic CRC [76].…”

Section: Hotairmentioning

confidence: 99%

Long Noncoding RNA in Digestive Tract Cancers: Function, Mechanism, and Potential Biomarker

et al. 2015

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Digestive tract cancers (DTCs) are a leading cause of cancerrelated death worldwide. Current therapeutic tools for advanced stage DTCs have limitations, and patients with early stage DTCs frequently have a missed diagnosis due to shortage of efficient biomarkers. Consequently, it is necessary to develop novel biomarkers for early diagnosis and novel therapeutic targets for treatment of DTCs. In recent years, long noncoding RNAs (lncRNAs), a class of noncoding RNAs with .200 nucleotides, have been shown to be aberrantly expressed in DTCs and to have an important role in DTC development: the expression profiles of lncRNAs strongly correlated with poor survival of patients with DTCs, and lncRNAs acted as oncogenes or tumor suppressor genes in DTC progression. In this review, we summarized the functional lncRNAs and expounded on their regulatory mechanisms in DTCs. The Oncologist 2015;20:898-906Implications for Practice: Digestive tract cancers (DTCs) are a leading cause of cancer-related death worldwide. It is necessary to exploit novel biomarkers for early diagnosis and novel therapeutic targets for treatment of DTCs. Long noncoding RNAs (lncRNAs), a class of noncoding RNAs with approximately 200 nucleotides to 100,000 bases, participate in the progression of a variety of diseases.This review summarizes functional lncRNAs, which were shown to serve as novel biomarkers for diagnosis and prognosis of DTCs and to act as oncogenes or tumor suppressor genes in DTC development. In addition,the potential mechanism of functional lncRNAs in DTCs is highlighted.

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“…Multiple protein markers are associated with EMT, including ZEB1, ZEB2, SNAI1, SNAI2, Vimentin, E-cadherin, and N-cadherin (Kalluri & Weinberg, 2009). HOTAIR has been associated with an increase in EMT and cancerous proliferation via suppression of E-cadherin, an epithelial marker, and alteration of nuclear organization to that of a more invasive mesenchymal cell (Wu et al, 2014). An important regulator of EMT, the SNAIL protein, is also shown to associate with HOTAIR in the nucleus and direct the methylation of targets to further promote EMT; again, in this situation HOTAIR acts as a scaffold bringing together SNAIL and the EZH2 subunit of PRC2 for targeted methylation (Battistelli et al, 2016).…”

Section: Hotair In Cellular Aberrancymentioning

confidence: 99%

The Master of Genomic Programs: HOTAIR in Cellular Development and Cancer Metastasis

Hammer¹,

Lohbauer²

2016

Aquila

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Originally thought of as "junk RNA", long non-coding RNA (lncRNA) has been shown over the last decade to play active regulatory roles in many vital cellular processes. The accepted primary mechanism of lncRNA regulatory activity is through chromatin remodeling and methylation of the genome, while there are also recent data to suggest additional mechanisms, such as altered RNA processing and enhancer activity. Aberrant expression of lncRNA has been linked with various disease processes, including cancer. One of the most well studied lncRNA, Hox Transcript Antisense Intergenic RNA (HO-TAIR), is one such lncRNA whose enhanced expression has been associated with carcinomas of the breast. In addition to reviewing the extensive research focused on HOTAIR expression and regulation of breast cancer through canonical pathways, we will examine new studies that suggest the ability of HOTAIR to regulate microRNA (another type of non-coding RNA) through direct binding inhibition, and how dysregulation of HOTAIR expression is relevant to breast cancer.

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Long non-coding RNA HOTAIR is a powerful predictor of metastasis and poor prognosis and is associated with epithelial-mesenchymal transition in colon cancer

Cited by 190 publications

References 24 publications

Long non-coding RNA HOTAIR is a marker for hepatocellular carcinoma progression and tumor recurrence

Long non-coding RNA HOTAIR is a marker for hepatocellular carcinoma progression and tumor recurrence

Long Noncoding RNA in Digestive Tract Cancers: Function, Mechanism, and Potential Biomarker

The Master of Genomic Programs: HOTAIR in Cellular Development and Cancer Metastasis

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