Long non-coding RNA HOTAIR in cervical cancer: Molecular marker, mechanistic insight, and therapeutic target

Zhou, Yanhui; Cui, Yanhui; Wang, Ting; Luo, Yang

doi:10.1016/bs.acc.2019.12.004

Cited by 29 publications

(18 citation statements)

References 137 publications

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“…For instance, lncRNA HOTAIR plays important roles in the development of cancer 23 – 26 . In cervical cancer, it was reported that high levels of circulating HOTAIR are correlated with tumor recurrence and short overall survival 27 , 28 . To date, the lncRNA profile in cervical adenocarcinoma remains largely unknown.…”

Section: Introductionmentioning

confidence: 99%

Transcriptome analysis uncovers the diagnostic value of miR-192-5p/HNF1A-AS1/VIL1 panel in cervical adenocarcinoma

Zou

et al. 2020

Sci Rep

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Despite the fact that the incidence of cervical squamous cell carcinoma has decreased, there is an increase in the incidence of cervical adenocarcinoma. However, our knowledge on cervical adenocarcinoma is largely unclear. Transcriptome sequencing was conducted to compare 4 cervical adenocarcinoma tissue samples with 4 normal cervical tissue samples. mRNA, lncRNA, and miRNA signatures were identified to discriminate cervical adenocarcinoma from normal cervix. The expression of VIL1, HNF1A-AS1, MIR194-2HG, SSTR5-AS1, miR-192-5p, and miR-194-5p in adenocarcinoma were statistically significantly higher than that in normal control samples. The Receiver Operating Characteristic (ROC) curve analysis indicated that combination of miR-192-5p, HNF1A-AS1, and VIL1 yielded a better performance (AUC = 0.911) than any single molecule -and could serve as potential biomarkers for cervical adenocarcinoma. Of note, the combination model also gave better performance than TCT test for cervical adenocarcinoma diagnosis. However, there was no correlation between miR-192-5p or HNF1A-AS1 and HPV16/18 E6 or E7. VIL1 was weakly correlated with HPV18 E7 expression. In summary, our study has identified miR-192-5p/HNF1A-AS1/VIL1 panel that accurately discriminates adenocarcinoma from normal cervix. Detection of this panel may provide considerable clinical value in the diagnosis of cervical adenocarcinoma.

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Section: Introductionmentioning

confidence: 99%

Transcriptome analysis uncovers the diagnostic value of miR-192-5p/HNF1A-AS1/VIL1 panel in cervical adenocarcinoma

Zou

et al. 2020

Sci Rep

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“…In CC, enhanced HOTAIR expression can lead to progressive tumor stages, lymphatic node and lymphatic vessel metastasis, adenocarcinoma, and poor prognosis. HOTAIR can increase the possibility of cervical cell tumor development, angiogenesis, and metastasis, e.g., by upregulating the expression of MMP-9, VEGF growth factors, or EMT-related genes [ 77 , 114 ], targeting miRNAs like miR-23b/MAPK1 axis, or regulating the expression of BCL-2 by miR-143-3p sponging [ 115 , 116 ].…”

Section: Lncrnas In Female-oriented Cancersmentioning

confidence: 99%

The Role of Long Non-Coding RNAs (lncRNAs) in Female Oriented Cancers

Naz

Tariq

Ali

et al. 2021

Cancers

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Recent advances in molecular biology have discovered the mysterious role of long non-coding RNAs (lncRNAs) as potential biomarkers for cancer diagnosis and targets for advanced cancer therapy. Studies have shown that lncRNAs take part in the incidence and development of cancers in humans. However, previously they were considered as mere RNA noise or transcription byproducts lacking any biological function. In this article, we present a summary of the progress on ascertaining the biological functions of five lncRNAs (HOTAIR, NEAT1, H19, MALAT1, and MEG3) in female-oriented cancers, including breast and gynecological cancers, with the perspective of carcinogenesis, cancer proliferation, and metastasis. We provide the current state of knowledge from the past five years of the literature to discuss the clinical importance of such lncRNAs as therapeutic targets or early diagnostic biomarkers. We reviewed the consequences, either oncogenic or tumor-suppressing features, of their aberrant expression in female-oriented cancers. We tried to explain the established mechanism by which they regulate cancer proliferation and metastasis by competing with miRNAs and other mechanisms involved via regulating genes and signaling pathways. In addition, we revealed the association between stated lncRNAs and chemo-resistance or radio-resistance and their potential clinical applications and future perspectives.

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“…Different lncRNAs play different roles in tumor regulation. LncRNAs such as HOTAIR ( Li et al, 2014 ; Yu and Li, 2015 ; Fu et al, 2016 ; Zhou et al, 2020 ), MALAT1, ANRIL and SRA are up-regulated in tumors and play the role of oncogenes, while MEG3, GASS and LncRNA-p21 are down-regulated in tumors and play a role of tumor suppressors. H19 ( Conigliaro et al, 2015 ; Jia et al, 2016 ; Jiang et al, 2016 ; Lv et al, 2017 ; Yuan et al, 2019 ; Liu Z.Z.…”

Section: Non-coding Rnas To Regulate Tumor Angiogenesismentioning

confidence: 99%

Non-coding RNAs in Regulating Tumor Angiogenesis

Song

Guo

Song

et al. 2021

Front. Cell Dev. Biol.

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Non-coding RNAs (ncRNAs) are RNAs that do not encode proteins, but perform biological functions in various physiological and pathological processes, including cancer formation, inflammation, and neurological diseases. Tumor blood vessels are a key target for cancer management. A number of factors regulate the angiogenesis of malignant tumors. NcRNAs participate in the regulation of tumor angiogenesis. Abnormal expression of ncRNAs act as tumor suppressors or oncogenes to affect the development of tumors. In this review we summarized the biological functions of ncRNAs, and discussed its regulatory mechanisms in tumor angiogenesis. This article will provide new insights for the research of ncRNAs in tumor angiogenesis.

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Long non-coding RNA HOTAIR in cervical cancer: Molecular marker, mechanistic insight, and therapeutic target

Cited by 29 publications

References 137 publications

Transcriptome analysis uncovers the diagnostic value of miR-192-5p/HNF1A-AS1/VIL1 panel in cervical adenocarcinoma

Transcriptome analysis uncovers the diagnostic value of miR-192-5p/HNF1A-AS1/VIL1 panel in cervical adenocarcinoma

The Role of Long Non-Coding RNAs (lncRNAs) in Female Oriented Cancers

Non-coding RNAs in Regulating Tumor Angiogenesis

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