Long Non-Coding RNA HCG11 Inhibits Glioma Cells Proliferation and Migration through Decoying miR-590-3p and Up-Regulating CADM2

Ma, Jinyang; Lang, Bojuan; Xue, Lixin; Wan, Ding; Sun, Tao

doi:10.1159/000521879

Cited by 4 publications

(4 citation statements)

References 39 publications

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“…Based on the study, CADM2 may servers as a cancer-suppressing gene [19,20,32]. For instance, CADM2 has the effect of inhibiting breast cancer EMT and metastasis [19]; upregulation of CADM2 also could glioma cell proliferation and migration [20,32]. Moreover, our study also denoted that miR-1303 also could induce proliferation and metastasis of LC cells through CADM2.…”

Section: Discussionsupporting

confidence: 51%

“…And this study also further con rmed the targeted relationship between CADM2 3'-UTR and miR-1303. Based on the study, CADM2 may servers as a cancer-suppressing gene [19,20,32]. For instance, CADM2 has the effect of inhibiting breast cancer EMT and metastasis [19]; upregulation of CADM2 also could glioma cell proliferation and migration [20,32].…”

Section: Discussionmentioning

confidence: 99%

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Hsa_circ_0002980 prevents proliferation, migration, invasion, and epithelial-mesenchymal transition of liver cancer cells through microRNA-1303/cell adhesion molecule 2 axis

Chen

et al. 2022

Preprint

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Background: Liver cancer (LC) is a hackneyed malignant tumor. And the dysregulation of circular RNA (circRNA) is relevant to the metastasis of LC. Hsa_circ_0002980 was unexpectedly found to be up-regulated in LC tissues, while its specific function remains unclear. Methods: Hsa_circ_0002980 expression was first confirmed by RT-qPCR. Then the impacts of circ_0002980 on the proliferation, metastasis, and EMT-related proteins of LC cells through clone formation, Flow cytometer, Transwell, and western blot. Besides, the relationship between circ_0002980 and miR-1303 or miR-1303 and CADM2 was analyzed by dual luciferase reporter assay, and the influences of these three genes on LC cell progression were determined through the rescued experiments.Results: Has_circ_0002980 expression was lowered in LC. And circ_0002980 overexpression had obvious inhibitory actions on the proliferation, migration, invasion, and EMT of LC cells. Besides, circ_0002980 specifically binds to miR-1303, the acceleration effect of miR-1303 overexpression on LC progression can be partially reversed by circ_0002980. Moreover, miR-1303 can also target CADM2, and CADM2-mediated prevention also could be attenuated by miR-1303 overexpression.Conclusions: In LC cells, circ_0002980 upregulation prevents cell proliferation, metastasis and EMT by affecting miR-1303/CADM2 axis. Therefore, we suggest that this axis may be a novel therapeutic target for LC.

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Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Hsa_circ_0002980 prevents proliferation, migration, invasion, and epithelial-mesenchymal transition of liver cancer cells through microRNA-1303/cell adhesion molecule 2 axis

Chen

et al. 2022

Preprint

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“…CADM2 as a number of cell adhesion molecule family has appeared among the top associations in a wide range of multiple cancers and plays an essential role in maintenance of cell polarity and normal cellular processes. CADM2 reported as a tumor inhibiting gene could suppress the Akt signaling pathway (29,30). Moreover, silencing the expression of CADM2 reverses the tumor suppressing effects induced by circDDX17 overexpression.…”

Section: Discussionmentioning

confidence: 97%

CircDDX17 inhibits invasive progression of pituitary adenomas by sponging miR-1279 and regulating CADM2 expression

Yue,

Lan,

Liu

2023

Front. Oncol.

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PurposeIncreasing evidence has revealed that circDDX17 plays significant regulatory roles in tumor progression. In the present study, we investigated the role of circDDX17 in pituitary adenomas (PAs).MethodsReverse transcription–quantitative PCR was performed to detect the expression of Circular RNA DDX17 (circDDX17), microRNA-1279 (miR-1279), and cell adhesion molecule 2 (CADM2) in PA tissues. Cell abilities of migration and invasion were examined by wound healing and transwell assays. Dual-luciferase reporter, RNA immunoprecipitation, and RNA pull-down assays were applied to confirm the associations among circDDX17, miR-1279, and CADM2. Xenograft tumor experiments were performed to investigate the roles of circDDX17 in vivo.ResultsIn the present study, we found that circDDX17 was downregulated in PA tissues correlated with invasion, tumor size, and progression-free survival of patients with PA. Enforced expression of circDDX17 significantly inhibited migration and invasion through miR-1279. Notably, CADM2 was verified as the direct binding target of miR-1279, and silencing the expression of CADM2 reverses the tumor suppressing effects induced by circDDX17 overexpression. We demonstrated that circDDX17 upregulated the expression of CADM2 by sponging miR-1279, which suppressed the invasive biological behaviors of PA.ConclusionCircDDX17 may serve as a tumor suppressor and potential promising biomarker and effectively therapeutic target for the management of PA.

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“…For instance, CADM2 inhibits breast cancer EMT and metastasis [ 20 ]. Additionally, the upregulation of CADM2 promotes glioma cell proliferation and migration [ 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

hsa_circ_0002980 prevents proliferation, migration, invasion, and epithelial-mesenchymal transition of liver cancer cells through microRNA-1303/cell adhesion molecule 2 axis

Wang,

Li,

et al. 2023

Aging

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Background: Liver cancer (LC) is a rare malignancy. Circular RNA (circRNA) dysregulation is associated with LC metastasis. hsa_circ_0002980 was found to be unexpectedly downregulated in LC tissues; however, its specific function remains unclear. Methods: hsa_circ_0002980 expression was confirmed using RT-qPCR. The effects of circ_0002980 on the proliferation, metastasis, and EMT-related proteins of LC cells were assessed using clone formation, flow cytometry, Transwell assays, and Western blotting. The relationship between circ_0002980 and miR-1303 or miR-1303 and CADM2 was analyzed using a dual-luciferase reporter assay. Thereafter, the influence of these three genes on LC cell progression was determined through rescue experiments. Results: hsa_circ_0002980 expression was lower in LC. circ_0002980 overexpression inhibited the proliferation, migration, invasion, and EMT of LC cells. In addition, circ_0002980 specifically binds to miR-1303, and the accelerated effect of miR-1303 overexpression on LC progression was partially reversed by circ_0002980. Moreover, miR-1303 can also target CADM2, and CADM2-mediated prevention can also be attenuated by miR-1303 overexpression. Conclusions: In LC cells, circ_0002980 upregulation prevents cell proliferation, metastasis, and EMT by affecting the miR-1303/CADM2 axis. Therefore, this axis may be a novel therapeutic target in LC.

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Long Non-Coding RNA HCG11 Inhibits Glioma Cells Proliferation and Migration through Decoying miR-590-3p and Up-Regulating CADM2

Cited by 4 publications

References 39 publications

Hsa_circ_0002980 prevents proliferation, migration, invasion, and epithelial-mesenchymal transition of liver cancer cells through microRNA-1303/cell adhesion molecule 2 axis

Hsa_circ_0002980 prevents proliferation, migration, invasion, and epithelial-mesenchymal transition of liver cancer cells through microRNA-1303/cell adhesion molecule 2 axis

CircDDX17 inhibits invasive progression of pituitary adenomas by sponging miR-1279 and regulating CADM2 expression

hsa_circ_0002980 prevents proliferation, migration, invasion, and epithelial-mesenchymal transition of liver cancer cells through microRNA-1303/cell adhesion molecule 2 axis

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