2020
DOI: 10.21203/rs.3.rs-104420/v1
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Long Non-Coding RNA H19 Expression and Functional Polymorphism rs217727 Are Linked to Increased Ischemic Stroke Risk

Abstract: Background: Efforts to identify potential biomarkers for the diagnosis of ischemic stroke (IS) are valuable. The H19 gene plays a functional role in increasing the prevalence of IS risk factors. We evaluated the correlation between H19 rs217727 polymorphism and the expression level of H19 lncRNA with susceptibility to IS among the Iranian population.Methods: Blood samples were collected from IS patients (n = 114) and controls (n = 114). We concentrated on the expression pattern of H19 at different time points … Show more

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Cited by 5 publications
(4 citation statements)
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“…There has been evidence that H19 has a significant effect on the onset, development, and progression stages of atherosclerosis [24] . A study in an Iranian population found that circulating levels of H19 within 24 h of ischemic stroke onset could be used as an early diagnostic biomarker [25] . Wang et al [26] found that peripheral blood mononuclear cell-derived H19 was a risk factor for acute myocardial infarction and had significant diagnostic value.…”
Section: Discussionmentioning
confidence: 99%
“…There has been evidence that H19 has a significant effect on the onset, development, and progression stages of atherosclerosis [24] . A study in an Iranian population found that circulating levels of H19 within 24 h of ischemic stroke onset could be used as an early diagnostic biomarker [25] . Wang et al [26] found that peripheral blood mononuclear cell-derived H19 was a risk factor for acute myocardial infarction and had significant diagnostic value.…”
Section: Discussionmentioning
confidence: 99%
“…118 Interestingly, in stroke patients, H19 was increased in the leukocytes, blood, and serum and circulating H19 levels were associated with increased risk for ischemic stroke. 110,112,116,119122 This indicates the potential of H19 to serve as a biomarker for the prognosis for ischemic stroke.…”
Section: Epigenetic Mechanisms In Strokementioning
confidence: 95%
“…In vitro, H19 targeted HDAC1 to inhibit the polarization of microglial M2 phenotype and promote neuroinflammation. (Jaworska et al, 2017;Rezaei et al, 2021;Wang et al, 2017a) Gu et al found that H19 expression was up-regulated in the spinal cord injury model compared with control mice. Up-regulation of H19 expression could promote apoptosis and inflammation of BV2 cells.…”
Section: H19mentioning
confidence: 99%