Long non-coding RNA GLIDR accelerates the tumorigenesis of lung adenocarcinoma by miR-1270/TCF12 axis

Tai, Guigang; Fu, Hongyi; Bai, Hongzhong; Liu, Hui; Li, Lijuan; Song, Tao

doi:10.1080/15384101.2021.1953754

Cited by 6 publications

(5 citation statements)

References 24 publications

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“…Among these 53 mRNAs, TCF12 caught our attention due to its elusive role in ESCC. TCF12 has been reported to be an oncogene in multiple malignant tumors, including hepatocellular carcinoma, glioma, melanoma, meningioma, and lung adenocarcinoma [15][16][17][18][19]. Specifically, TCF12 was reported as a key regulator in EMT by transcriptionally repressing the expression of E-cadherin in colorectal cancer [20], and TCF12 was also verified to facilitate the EMT process by activating the PI3K/AKT signaling pathway in glioma [15].…”

Section: Discussionmentioning

confidence: 99%

“…By overlapping the analysis, we screened out 53 candidate mRNAs that had the potential to be downregulated by miR-342-3p in ESCC (Figure 5A). Among these 53 mRNAs, TCF12 caught our attention due to its tumor-promoting effect on multiple malignant tumors, including hepatocellular carcinoma, glioma, melanoma, meningioma, and lung adenocarcinoma [15][16][17][18][19]. However, the role of TCF12 in ESCC is elusive.…”

Section: Figure 3 Circcrim1 Acts As a Competing Endogenous Ran (Cerna...mentioning

confidence: 99%

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Circular RNA hsa_circ_0002938 (circCRIM1) promotes the progression of esophageal squamous cell carcinoma by upregulating transcription factor 12

Li¹,

Jia²,

Duan³

et al. 2023

neo

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Growing evidence has indicated that circular RNAs (circRNAs) play crucial roles in the tumorigenesis and progression of diverse malignancies. However, the majority of circRNAs involved in esophageal squamous cell carcinoma (ESCC) remain undefined and the exact functions and underlying mechanisms of circRNAs in ESCC still need further exploration. In this study, we identified a novel onco-circRNA hsa_circ_0002938, derived from the exons of cysteine-rich transmembrane BMP regulator 1 (CRIM1) pre-mRNA, referred to as circCRIM1. We found that the expression of circCRIM1 was higher in ESCC tissues, compared to para-carcinoma tissues. Increased expression of circCRIM1 was positively correlated with clinical parameters of ESCC patients including tumor-node-metastasis (TNM) stage, tumor invasion range, and lymph node metastasis. Functionally, the results from the experiments in vitro showed that the knockdown of circCRIM1 suppressed proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in ESCC cells. By conducting bioinformatics algorithms analyses and microRNA (miRNA) rescue experiments, we found that circCRIM1 could act as a competing endogenous RNA (ceRNA) to sponge miR-342-3p in ESCC cells, and thereby upregulated the expression of transcription factor 12 (TCF12), a key regulator promoting the EMT process. Taken together, circCRIM1 facilitates the progression of ESCC by sponging miR-342-3p to regulate TCF12 and promote EMT, and the circCRIM1/miR-342-3p/TCF12 axis may be regarded as a potential predictive biomarker and therapeutic target for treating ESCC.

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Section: Discussionmentioning

confidence: 99%

Section: Figure 3 Circcrim1 Acts As a Competing Endogenous Ran (Cerna...mentioning

confidence: 99%

Circular RNA hsa_circ_0002938 (circCRIM1) promotes the progression of esophageal squamous cell carcinoma by upregulating transcription factor 12

Li¹,

Jia²,

Duan³

et al. 2023

neo

View full text Add to dashboard Cite

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“…NR2F1-AS1 is also upregulated in dormant breast cancer stem-like cells and increases tumor dissemination by recruiting PTBP1 to the mRNA of its sense gene ( NR2F1 ), promoting its translation so that NR2F1 represses ΔNp63 transcription [ 76 ]. GLIDR is upregulated and promotes glioma [ 77 ], lung [ 78 ], and prostate [ 79 ] cancers by acting as competing endogenous RNAs for miRNAs. ERVK13-3 is upregulated in osteosarcoma [ 80 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of lncRNAs Deregulated in Epithelial Ovarian Cancer Based on a Gene Expression Profiling Meta-Analysis

Salamini-Montemurri

Lamas-Maceiras

Lorenzo-Catoira

et al. 2023

IJMS

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Epithelial ovarian cancer (EOC) is one of the deadliest gynecological cancers worldwide, mainly because of its initially asymptomatic nature and consequently late diagnosis. Long non-coding RNAs (lncRNA) are non-coding transcripts of more than 200 nucleotides, whose deregulation is involved in pathologies such as EOC, and are therefore envisaged as future biomarkers. We present a meta-analysis of available gene expression profiling (microarray and RNA sequencing) studies from EOC patients to identify lncRNA genes with diagnostic and prognostic value. In this meta-analysis, we include 46 independent cohorts, along with available expression profiling data from EOC cell lines. Differential expression analyses were conducted to identify those lncRNAs that are deregulated in (i) EOC versus healthy ovary tissue, (ii) unfavorable versus more favorable prognosis, (iii) metastatic versus primary tumors, (iv) chemoresistant versus chemosensitive EOC, and (v) correlation to specific histological subtypes of EOC. From the results of this meta-analysis, we established a panel of lncRNAs that are highly correlated with EOC. The panel includes several lncRNAs that are already known and even functionally characterized in EOC, but also lncRNAs that have not been previously correlated with this cancer, and which are discussed in relation to their putative role in EOC and their potential use as clinically relevant tools.

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“…Numerous miRNAs, such as Linc00520 and Linc01833, are highly expressed in LUAD. They mainly promote cancer cells via the lncRNA/miRNA/mRNA axis (186)(187)(188)(189)(190)(191)(192)(193)195). Indeed, lncRNAs exhibit inhibitory effects on cancer phenotypes in LUAD.…”

Section: Interactions Of Lncrna and Circrna With Mirna In Luadmentioning

confidence: 99%

MicroRNA‑mediated regulation in lung adenocarcinoma: Signaling pathways and potential therapeutic implications (Review)

Liu,

Zhang,

Wang

et al. 2023

Oncol Rep

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Lung adenocarcinoma (LUAD) poses a significant global health burden owing to its high incidence rate and unfavorable prognosis, driven by frequent recurrence and drug resistance. Understanding the biological mechanisms underlying LUAD is imperative to developing advanced therapeutic strategies. Recent research has highlighted the role of dysregulated microRNAs (miRNAs) in LUAD progression through diverse signaling pathways, including the Wnt and AKT pathways. Of particular interest is the novel pathological mechanism involving the interaction between competing endogenous RNAs (ceRNAs) and miRNAs. This review critically analyzed the impact of aberrant miRNA expression on LUAD development, shedding light on the associated signaling pathways. It also highlighted the emerging significance of ceRNA-miRNA interactions in LUAD pathogenesis. Elucidating the intricate regulatory networks involving miRNAs and ceRNAs presents a promising avenue for the development of potential therapeutic interventions and diagnostic biomarkers in LUAD. Further research in this area is essential to advance precision medicine approaches and improve patient outcomes. Contents1. Introduction 2. Role of miRNA in LUAD 3. miRNA-mediated targeting of specific signaling pathways in LUAD 4. Interactions of lncRNA and circRNA with miRNA in LUAD 5. Limitations and outlook 6. Conclusions

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Long non-coding RNA GLIDR accelerates the tumorigenesis of lung adenocarcinoma by miR-1270/TCF12 axis

Cited by 6 publications

References 24 publications

Circular RNA hsa_circ_0002938 (circCRIM1) promotes the progression of esophageal squamous cell carcinoma by upregulating transcription factor 12

Circular RNA hsa_circ_0002938 (circCRIM1) promotes the progression of esophageal squamous cell carcinoma by upregulating transcription factor 12

Identification of lncRNAs Deregulated in Epithelial Ovarian Cancer Based on a Gene Expression Profiling Meta-Analysis

MicroRNA‑mediated regulation in lung adenocarcinoma: Signaling pathways and potential therapeutic implications (Review)

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