Long non-coding RNA FTX predicts a poor prognosis of human cancers: a meta-analysis

Abstract

Background Several studies assessed the relationship between FTX expression level and clinicopathological features and survival outcomes in patients with cancer, but these results were conflicting. This meta-analysis aimed to synthesize existing data to clarify the association of FTX with prognosis of cancers. Methods Electronic databases of PubMed, Embase, Cochrane library, Web of Science, Chinese CNKI, and the Chinese WanFang databases were used to search for relevant studies. Role of FTX in cancers was evaluated by pooled odds ratios (ORs) and hazard ratios (HRs) with 95% confidence intervals (CIs). Results In total, 11 studies compromising 1210 participants including colorectal cancer (CRC), hepatocellular carcinoma (HCC), gastric cancer (GC), renal cell carcinoma (RCC), osteosarcoma (OSC), and glioma, were enrolled in this analysis. The meta-analysis showed that high FTX expression was associated with lymph node metastasis, distant metastasis, tumor size and TNM/clinical stage. More importantly, the pooled results from survival analysis revealed that there was a significant correlation between high FTX expression and a shorter OS in patients with HCC, CRC, GC, OSC, and glioma, and that FTX overexpression could be an independent predictive marker for shorter OS in patients with CRC, HCC, OSC, and glioma. Conclusions FTX may be a potential oncogene, and high FTX expression be associated with a poor prognosis in patients with CRC, HCC, OSC, and glioma.

The emerging role of lncRNAs in osteoarthritis development and potential therapy

“…LncRNA SNHG15 sponged miR-141-3p and elevated the expression of BCL2L13, resulting in prevention of osteoarthritis progression . Similarly, one group found that lncRNA SNHG15 regulated ECM homeostasis and attenuated the progression of osteoarthritis (Chen et al, 2020a). Fan and colleagues reported that lncRNA SNHG16 accelerated osteoarthritis occurrence via interaction with miR-373-3p (Fan et al, 2021).…”

Clinicopathological and prognostic value of lncRNAs expression in gastric cancer: A field synopsis of observational studies and databases validation

“…The Meta-analysis of gastric cancer-related lncRNA has mainly focused on the systematic evaluation of single lncRNA [20,21] and the risk of gastric cancer or the prognosis of lncRNA and different cancers. [21,22] In addition to including more recent studies, in our study, a 2-sample Z-test was used to see whether the HR differ by log rank or multivariate analysis, Meanwhile, we compared the results with log rank and multivariate analysis to verify the reliability and stability of the results.…”