Long non-coding RNA FTH1P3 regulated metastasis and invasion of esophageal squamous cell carcinoma through SP1/NF-kB pathway

Yang, Lijun; Sun, Kang; Chu, Jie; Qu, Yue; Zhao, Xue; Yin, Hang; Ming, Liang; Wan, Junhu; He, Fucheng

doi:10.1016/j.biopha.2018.07.129

Cited by 42 publications

(26 citation statements)

References 37 publications

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“…[36][37][38] SP1 is also reported to be highly expressed in ESCC, and the upregulation of SP1 is closely related to the malignant progression of ESCC. [39][40][41] Our study indicates that the knockdown of FGD5-AS1 reduces miR-383 sponging, thus reducing SP1 expression in ESCC, thereby diminishing the malignancy of ESCC cells in vitro and in vivo. These results point to an ESCC pathogenesis-related regulatory network, which is composed of FGD5-AS1, miR-383, and SP1.…”

Section: Discussionmentioning

confidence: 72%

Long Noncoding RNA FGD5-AS1 Acts as a Competing Endogenous RNA on microRNA-383 to Enhance the Malignant Characteristics of Esophageal Squamous Cell Carcinoma by Increasing SP1 Expression

Jia

Zhang

Hong

et al. 2020

CMAR

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These authors contributed equally to this workPurpose: Previous studies have identified the important roles of a long noncoding RNA called FGD5 antisense RNA 1 (FGD5-AS1) in several types of human cancer. Nonetheless, to our knowledge, the expression and functions of FGD5-AS1 in esophageal squamous cell carcinoma (ESCC) have not been clarified. In this study, we aimed to determine the expression status of long noncoding RNA FGD5-AS1 in ESCC, determine its participation in ESCC progression, and uncover the underlying mechanisms. Methods: ESCC tissue samples and paired normal adjacent tissues were collected to quantify FGD5-AS1 expression by reverse-transcription quantitative PCR. The effects of FGD5-AS1 on ESCC cell proliferation, apoptosis, migration, and invasion in vitro as well as tumor growth in vivo were studied using a Cell Counting Kit-8 assay, flow cytometry, Transwell migration and invasion assays, and an in vivo tumor xenograft experiment. Results: FGD5-AS1 was found to be aberrantly upregulated in both ESCC tumors and cell lines compared to the control groups. Increased FGD5-AS1 expression manifested a close association with tumor size, TNM stage, and lymph node metastasis in patients with ESCC. Overall survival of patients with ESCC was shorter in the FGD5-AS1 high-expression group than in the FGD5-AS1 low-expression group. An FGD5-AS1 knockdown markedly attenuated ESCC cell proliferation, migration, and invasion and promoted apoptosis in vitro as well as slowed tumor growth in vivo. Mechanism investigation revealed that FGD5-AS1 can increase SP1 expression by sponging microRNA-383 (miR-383), thus functioning as a competing endogenous RNA. An miR-383 knockdown and recovery of SP1 expression attenuated the inhibition of the malignant characteristics of ESCC cells by the FGD5-AS1 knockdown. Conclusion: Thus, FGD5-AS1 enhances the aggressive phenotype of ESCC cells in vitro and in vivo via the miR-383-SP1 axis, which may represent a novel target for ESCC therapy.

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Section: Discussionmentioning

confidence: 72%

Long Noncoding RNA FGD5-AS1 Acts as a Competing Endogenous RNA on microRNA-383 to Enhance the Malignant Characteristics of Esophageal Squamous Cell Carcinoma by Increasing SP1 Expression

Jia

Zhang

Hong

et al. 2020

CMAR

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“…Researchers have focused for years to investigate the pathogenesis underlying lncRNAs mediated tumorigenesis. Emerging evidence showed that numerous lncRNAs are critical regulators of metastasis, differentiation, and metabolism of multiple human cancers [15,16]. Several lncRNAs have been reported to be involved in PTC tumorigenesis and progression.…”

Section: Discussionmentioning

confidence: 99%

lncRNA SNHG3 acts as a novel Tumor Suppressor and regulates Tumor Proliferation and Metastasis via AKT/mTOR/ERK pathway in Papillary Thyroid Carcinoma

Duan¹,

Wang²,

Xu³

et al. 2020

J. Cancer

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The incidence of papillary thyroid carcinoma (PTC) has been increased rapidly in recent decades. Long noncoding RNAs (lncRNA) are a class of non-protein-coding transcripts and play critical roles in regulating gene expression and influence biological behaviors of multiple cancers, including PTC. Here, we discovered that lncRNA SNHG3 was significantly downregulated in PTC tissues and cell lines, the expression of SNHG3 was negatively correlated with the TNM stage and poor prognosis of PTC patients. Functional studies illustrated that the depletion of SNHG3 via CRISPR/Cas9 technology promoted the proliferation, migration and invasion abilities of PTC cells. Tumor xenograft models confirmed the tumor-promoting role of silenced SNHG3 in vivo. Further mechanistic analyses revealed that knockout of SNHG3 activated the AKT/mTOR/ERK pathway in PTC cell lines and the mTOR inhibitor AZD8055 abrogated the tumor-promoting effect induced by SNHG3 inhibition. Taken together, our findings identified a lncRNA SNHG3 that functions its tumor-suppressor role during PTC development and SNHG3 might serve as a promising candidate for target therapy of PTC.

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“…Enhanced expression of PTTG3P greatly stimulated migration and invasion of esophageal squamous cell carcinoma through upregulating expression levels of PTTG1 and PTTG2 . Yang L. et al (2018) demonstrated that FTH1P3 was notably upregulated in esophageal squamous cell carcinoma and knockdown of FTH1P3 significantly inhibited proliferation, migration and invasion of esophageal squamous cell carcinoma cells by regulating SP1/NF-kB signaling. The study conducted certified an obvious increased expression of DUXAP10 in esophageal squamous cell carcinoma.…”

Section: Endometrial Cancermentioning

confidence: 96%

Pseudogene-Derived lncRNAs and Their miRNA Sponging Mechanism in Human Cancer

Lou

Ding

2020

Front. Cell Dev. Biol.

124

115

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Long non-coding RNA FTH1P3 regulated metastasis and invasion of esophageal squamous cell carcinoma through SP1/NF-kB pathway

Cited by 42 publications

References 37 publications

<p>Long Noncoding RNA <em>FGD5-AS1</em> Acts as a Competing Endogenous RNA on microRNA-383 to Enhance the Malignant Characteristics of Esophageal Squamous Cell Carcinoma by Increasing SP1 Expression</p>

<p>Long Noncoding RNA <em>FGD5-AS1</em> Acts as a Competing Endogenous RNA on microRNA-383 to Enhance the Malignant Characteristics of Esophageal Squamous Cell Carcinoma by Increasing SP1 Expression</p>

lncRNA SNHG3 acts as a novel Tumor Suppressor and regulates Tumor Proliferation and Metastasis via AKT/mTOR/ERK pathway in Papillary Thyroid Carcinoma

Pseudogene-Derived lncRNAs and Their miRNA Sponging Mechanism in Human Cancer

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