Long non‐coding RNA F11‐AS1 inhibits HBV‐related hepatocellular carcinoma progression by regulating NR1I3 <i>via</i> binding to microRNA‐211‐5p

Deng, Yibin; Wei, Zhongheng; Huang, Meijin; Xu, Guidan; Wei, Wujun; Peng, Bin; Nong, Shunqiang; Qin, Houji

doi:10.1111/jcmm.14881

Cited by 27 publications

(25 citation statements)

References 42 publications

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“…F11-AS1 can inhibit HBV-related hepatocellular carcinoma progression by regulating NR1I3 via binding to microRNA-211-5p. LINC01018 has a novel tumor suppressor role in hepatocellular carcinoma by sponging miR-182-5p [ 9 , 10 ]. We also found lower expression of m 6 A-modified MIR325HG to be correlated with worse patient survival in both LGG and GBM (Fig.…”

Section: Association Of M 6 A-modified Te Lncrnas mentioning

confidence: 99%

Pan-cancer characterization of expression and clinical relevance of m6A-related tissue-elevated long non-coding RNAs

Cai

Zhang

et al. 2021

Mol Cancer

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Section: Association Of M 6 A-modified Te Lncrnas mentioning

confidence: 99%

Pan-cancer characterization of expression and clinical relevance of m6A-related tissue-elevated long non-coding RNAs

Cai

Zhang

et al. 2021

Mol Cancer

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“…lncRNA F11-AS1 was under-expressed and attenuated tumor growth and metastasis capacity via the F11-AS1/miR-3146/PTEN axis in HCC [29]. In addition, the low expression of lncRNA F11-AS1 was correlated with poor prognosis in patients with HBV-related HCC via regulation of the miR-211-5p /NR1I3 pathway [30]. A study revealed that LINC00942 acts as an oncogene that promotes cell proliferation and colony formation and inhibits cell apoptosis, subsequently elevating METTL14-mediated m6A methylation levels in breast cancer initiation and progression by LNC942-METTL14-CXCR4/CYP1B1 signaling axis [31].…”

Section: Discussionmentioning

confidence: 94%

Identification of an Epithelial-Mesenchymal Transition-Related Long Non-coding RNA Prognostic Signature for Hepatocellular Carcinoma

Huang¹,

Li²,

Zhuang³

et al. 2021

Preprint

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Introduction: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors with poor prognosis. Epithelial–mesenchymal transition (EMT) is crucial for cancer progression and associates with a worse prognosis. Thus, we aimed to construct an EMT-related lncRNAs signature for predicting the prognosis of HCC patients.Methods: We built an EMT-related lncRNA risk signature in the training set by using Cox regression and LASSO regression based on TCGA database. Kaplan-Meier survival analysis was conducted to compare the overall survival (OS) in different risk groups. Cox regression was performed to explore whether the signature could be used as an independent factor. A nomogram was built involving the risk score and clinicopathological features. Furthermore, we explored the biological functions and immune states in two groups.Results: 12 EMT-related lncRNAs were obtained for constructing the prognosis model in HCC. The Kaplan-Meier curve analysis revealed that patients in the high-risk group had worse survival than low-risk group. Time-dependent ROC and Cox regression analyses suggested that the signature could predict HCC survival exactly and independently. The prognostic value of the risk model was confirmed in the validation group. The nomogram was built and could accurately predict survival of HCC patients. GSEA results showed that in high-risk group cancer-related pathways were enriched, and exhibited more cell division activity suggested by Gene Ontology (GO) analysis.Conclusions: We established a novel EMT-related prognostic risk signature including 12 lncRNAs and constructed a nomogram to predict the prognosis in HCC patients, which may improve prognostic predictive accuracy for HCC patients and guide the individualized treatment methods for the patients with HCC.

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Section: Long Non-coding Rnas (Lncrnas)mentioning

confidence: 99%

“…In HepG2.2.15 cells that stably express hepatitis B virus (HBV), the HBx protein inhibits the expression of the lncRNA F11-AS1 and induces that of CAR mRNA [173]. The lncRNA F11-AS1 binds to miR-211-5p, weakening its ability to bind to CAR and inhibit its expression [173]. Emerging evidence has demonstrated that lncRNAs can function as competing endogenous RNAs (ceRNAs) for specific miRNAs, regulating their function and downstream targets [175].…”

Section: Long Non-coding Rnas (Lncrnas)mentioning

confidence: 99%

Regulation of CAR and PXR Expression in Health and Disease

Daujat-Chavanieu

Gerbal‐Chaloin

2020

Cells

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Pregnane X receptor (PXR, NR1I2) and constitutive androstane receptor (CAR, NR1I3) are members of the nuclear receptor superfamily that mainly act as ligand-activated transcription factors. Their functions have long been associated with the regulation of drug metabolism and disposition, and it is now well established that they are implicated in physiological and pathological conditions. Considerable efforts have been made to understand the regulation of their activity by their cognate ligand; however, additional regulatory mechanisms, among which the regulation of their expression, modulate their pleiotropic effects. This review summarizes the current knowledge on CAR and PXR expression during development and adult life; tissue distribution; spatial, temporal, and metabolic regulations; as well as in pathological situations, including chronic diseases and cancers. The expression of CAR and PXR is modulated by complex regulatory mechanisms that involve the interplay of transcription factors and also post-transcriptional and epigenetic modifications. Moreover, many environmental stimuli affect CAR and PXR expression through mechanisms that have not been elucidated.

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Long non‐coding RNA F11‐AS1 inhibits HBV‐related hepatocellular carcinoma progression by regulating NR1I3 via binding to microRNA‐211‐5p

Cited by 27 publications

References 42 publications

Pan-cancer characterization of expression and clinical relevance of m6A-related tissue-elevated long non-coding RNAs

Pan-cancer characterization of expression and clinical relevance of m6A-related tissue-elevated long non-coding RNAs

Identification of an Epithelial-Mesenchymal Transition-Related Long Non-coding RNA Prognostic Signature for Hepatocellular Carcinoma

Regulation of CAR and PXR Expression in Health and Disease

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