Long non‑coding RNA BC168687 small interfering RNA reduces high glucose and high free fatty acid‑induced expression of P2X7 receptors in satellite glial cells

Liu, Cheng‐Long; Deng, Zhi-Xiong; Du, Errong; Xu, Changshui

doi:10.3892/mmr.2018.8601

Cited by 19 publications

(15 citation statements)

References 58 publications

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“…ATP can activate phospholipase C, which produces diacylglycerol and induces sensitization of TRPV1 leading to diabetic neuropathy (Chiba et al, 2017). BC168687 siRNA also extensively decreased the expression level (messenger RNA [mRNA] and protein) of TRPV1 receptors in DRG as well as the P2X7 receptor (Liu, Deng, Du, & Xu, 2018), which were confirmed by time quantitative polymerase chain reaction (PCR) and Western blot. Inflammatory cytokines are released more from SGCs of DRG after the activated TRPV1 receptor enables input of Ca+.…”

Section: Lncrnas In Dnp Research Related To P38 Signaling Pathwaysmentioning

confidence: 83%

Long non coding RNAs involved in MAPK pathway mechanism mediates diabetic neuropathic pain

Ren

Yang

et al. 2020

Cell Biology International

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Diabetes is the largest global epidemic of the 21st century, and the cost of diabetes and its complications comprise about 12% of global health expenditure. Diabetic neuropathy is the most common complication of diabetes, affecting up to 50% of patients over the course of their disease. Among them, 30%–50% develop neuropathic pain, which has typical symptoms that originate from the toes and progress to foot ulcers and seriously influence quality of life. The pathogenesis of diabetic neuropathic pain (DNP) is complicated and incompletely understood and there is no effective treatment except supportive treatment. Long noncoding RNAs (lncRNAs), a class of noncoding RNAs exceeding 200 nucleotides in length, have been shown to play key roles in fundamental cellular processes, and are considered to be potential targets for treatment. Recent research indicates that lncRNA is involved in the pathogenesis of DNP. Certain overexpressed lncRNAs can enhance the purinergic receptor‐mediated neuropathic pain in peripheral ganglia and inflammatory cytokines are released due to receptors activated by adenosine triphosphate. In recent years, our laboratory also has been exploring the relationship and pathogenesis between lncRNAs and DNP. In this review, we focus on the recent progress in functional lncRNAs associated with DNP and investigate their roles related to respective receptors.

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Section: Lncrnas In Dnp Research Related To P38 Signaling Pathwaysmentioning

confidence: 83%

Long non coding RNAs involved in MAPK pathway mechanism mediates diabetic neuropathic pain

Ren

Yang

et al. 2020

Cell Biology International

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“…Additionally, a recent study showed that uc.48+ participate in pain transmission in trigeminal neuralgia, the most common NP in the facial area, via upregulating expression of P2X7 receptor and furthermore enhance the phosphorylation of ERK1/2 [52]. Similarly, BC168687 siRNA inhibited the expression of P2X7 receptors and influenced the pathological process of DNP [53,54]. In another study, MRAK009713 directly interacted with the P2X3 protein expressed in the CCI rat model and potentiated P2X3 receptor function [55].…”

Section: Lncrnas Mediate P2x Receptorsmentioning

confidence: 93%

“…This receptor is engaged both in inflammation and in NP. Researchers have shown that small inhibitory RNA to NONRATT021972, uc.48+, and BC168687 can inhibit the expression of P2X7 receptor expression in a DNP rat model and modulate ion channel expression, thereby alleviating the symptoms of NP [46,47,50,53,54]. In addition, researchers used bioinformatics and found that calcium ion transport was the second most significant biological process of differentiate expressed lncRNAs [24].…”

Section: Lncrnas Alter Np-related Ion Channelsmentioning

confidence: 99%

Functional roles of lncRNAs and its potential mechanisms in neuropathic pain

Tang¹,

Zhou²,

Jing³

et al. 2019

Clin Epigenet

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Neuropathic pain (NP) is ranked as one of the major forms of chronic pain and emerges as a direct consequence of a lesion or disease affecting the somatosensory nervous system. Despite great advances into the mechanisms of NP, clinical practice is still not satisfactory. Fortunately, progress in elucidating unique features and multiple molecular mechanisms of long non-coding RNAs (lncRNAs) in NP has emerged in the past 10 years, suggesting that novel therapeutic strategies for pain treatment may be proposed. In this review, we will concentrate on recent studies associated with lncRNAs in NP. First, we will describe the alterations of lncRNA expression after spinal cord injury (SCI) and peripheral nerve injury (PNI), and then we illustrate the role of some specific lncRNAs in detail, which may offer new insights into our understanding of the etiology and pathophysiology of NP. Finally, we put special emphasis on the altered expression of lncRNAs in the diverse biological process of NP. Recent advances we summarized above in the development of NP may facilitate translation of these findings from bench to bedside in the future.

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“…is time-dependent and varies between strains and species [182,183,185]. LncRNAs play important roles in neuropathic pain processes not only in neurons, but also in non-neuronal cells, such as Schwann cells, satellite glial cells, macrophages and microglia [74,83,185,[188][189][190][191].…”

Section: Lncrnas As Possible Signatures For Pain Disordersmentioning

confidence: 99%

Non-coding RNAs in neuropathic pain

2020

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Neuro-immune alterations in the peripheral and central nervous system play a role in the pathophysiology of chronic pain in general, and members of the non-coding RNA (ncRNA) family, specifically the short, 22 nucleotide microRNAs (miRNAs) and the long non-coding RNAs (lncRNAs) act as master switches orchestrating both immune as well as neuronal processes. Several chronic disorders reveal unique ncRNA expression signatures, which recently generated big hopes for new perspectives for the development of diagnostic applications. lncRNAs may offer perspectives as candidates indicative of neuropathic pain in liquid biopsies. Numerous studies have provided novel mechanistic insight into the role of miRNAs in the molecular sequelae involved in the pathogenesis of neuropathic pain along the entire pain pathway. Specific processes within neurons, immune cells, and glia as the cellular components of the neuropathic pain triad and the communication paths between them are controlled by specific miRNAs. Therefore, nucleotide sequences mimicking or antagonizing miRNA actions can provide novel therapeutic strategies for pain treatment, provided their human homologues serve the same or similar functions. Increasing evidence also sheds light on the function of lncRNAs, which converge so far mainly on purinergic signalling pathways both in neurons and glia, and possibly even other ncRNA species that have not been explored so far.

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Long non‑coding RNA BC168687 small interfering RNA reduces high glucose and high free fatty acid‑induced expression of P2X7 receptors in satellite glial cells

Cited by 19 publications

References 58 publications

Long non coding RNAs involved in MAPK pathway mechanism mediates diabetic neuropathic pain

Long non coding RNAs involved in MAPK pathway mechanism mediates diabetic neuropathic pain

Functional roles of lncRNAs and its potential mechanisms in neuropathic pain

Non-coding RNAs in neuropathic pain

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