Long non-coding RNA BBOX1-antisense RNA 1 enhances cell proliferation and migration and suppresses apoptosis in oral squamous cell carcinoma via the miR-3940-3p/laminin subunit gamma 2 axis

Zhao, Chenyang; Shi, Wei; Chen, Min

doi:10.1080/21655979.2022.2059982

Cited by 12 publications

(11 citation statements)

References 45 publications

(46 reference statements)

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“…BBOX1-AS1 exerts its regulatory function in different tumors by competitively binding to various miRNAs. For example, in oral squamous cell carcinoma [ 35 ], BBOX1-AS1 acts as a sponge for miR-3940-3p, resulting in the upregulation of LAMC2, which promotes tumor cell proliferation and migration while inhibiting apoptosis.…”

Section: Bbox1-as1 Modulates Gene Expression Through a Cerna Networkmentioning

confidence: 99%

“…BBOX1-AS1 demonstrates upregulation in a wide range of human tumors (Fig. 1 ), including pituitary adenoma (PA) [ 34 ], oral squamous cell carcinoma (OSCC) [ 35 ], nasopharyngeal carcinoma (NPC) [ 36 , 37 ], non-small cell lung cancer (NSCLC) [ 38 – 40 ], esophageal carcinoma (EC) [ 41 – 45 ], hepatocellular carcinoma (HCC) [ 46 , 47 ], gastric cancer (GC) [ 48 ], colorectal cancer (CRC) [ 49 , 50 ], ovarian cancer (OC) [ 51 ], and cervical cancer (CC) [ 52 , 53 ]. High expression levels of BBOX1-AS1 in tumor patients have been linked to adverse clinicopathological features and poor prognosis, including lymph node metastasis, tumor size, clinical stage, overall survival (OS), and disease-free survival (DFS).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A review on the role of gamma-butyrobetaine hydroxylase 1 antisense RNA 1 in the carcinogenesis and tumor progression

Hu,

Liu,

Zhou

et al. 2023

Cancer Cell Int

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Gamma-butyrobetaine hydroxylase 1 antisense RNA 1 (BBOX1-AS1), located on human chromosome 11 p14, emerges as a critical player in tumorigenesis with diverse oncogenic effects. Aberrant expression of BBOX1-AS1 intricately regulates various cellular processes, including cell growth, epithelial–mesenchymal transition, migration, invasion, metastasis, cell death, and stemness. Notably, the expression of BBOX1-AS1 was significantly correlated with clinical-pathological characteristics and tumor prognoses, and it could also be used for the diagnosis of lung and esophageal cancers. Through its involvement in the ceRNA network, BBOX1-AS1 competitively binds to eight miRNAs in ten different cancer types. Additionally, BBOX1-AS1 can directly modulate downstream protein-coding genes or act as an mRNA stabilizer. The implications of BBOX1-AS1 extend to critical signaling pathways, including Hedgehog, Wnt/β-catenin, and MELK/FAK pathways. Moreover, it influences drug resistance in hepatocellular carcinoma. The present study provides a systematic review of the clinical significance of BBOX1-AS1’s aberrant expression in diverse tumor types. It sheds light on the intricate molecular mechanisms through which BBOX1-AS1 influences cancer initiation and progression and outlines potential avenues for future research in this field.

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Section: Bbox1-as1 Modulates Gene Expression Through a Cerna Networkmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A review on the role of gamma-butyrobetaine hydroxylase 1 antisense RNA 1 in the carcinogenesis and tumor progression

Hu,

Liu,

Zhou

et al. 2023

Cancer Cell Int

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“…This seems to be a common phenomenon that is detectable in cell lines of different carcinoma entities and is communicated as being associated with epithelial to mesenchymal transition (EMT) and the EGFR pathway [90][91][92]. Additionally, for OSCCs, a relation between Lng2 expression and cancer cell motility, along with a regulatory effect of different miRNAs or long non-coding RNAs, has been assessed [93,94]. Additionally, there seems to be a relation between Lng2 expression in carcinoma cells, EGFR signaling, and EMT.…”

Section: Laminin γ2 Chain Reorganization In the Oscc Invasive Front: ...mentioning

confidence: 99%

Invasion-Associated Reorganization of Laminin 332 in Oral Squamous Cell Carcinomas: The Role of the Laminin γ2 Chain in Tumor Biology, Diagnosis, and Therapy

Berndt

Gaßler

Franz

2022

Cancers

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Invasion of the connective tissue by carcinoma cells is accompanied by disintegration and reorganization of the hemidesmosomes, which connect the basement membrane to the basal epithelial cells. In terms of mediating the basement membrane, i.e., basal cell interactions, the heterotrimeric laminin 332 is the most important bridging molecule. Due to this distinct function, laminin 332, especially its gamma 2 chain, came into the focus of cancer research. Specific de novo synthesis and deposition patterns of laminin 332 are evident upon development and progression of oral squamous cell carcinomas (OSCCs). Loss from the basement membrane, cytoplasmic accumulation, and extracellular deposition are associated with crucial processes such as stromal activation and immune response, epithelial to mesenchymal transition, and tumor cell budding. In networks with components of the tumor microenvironment, altered expression of laminin 332 chains, proteolytic processing, and interaction with integrin receptors seem to promote cancer cell migration. Indeed, reorganization patterns are shown to have a high diagnostic and prognostic value. Here, we summarize the current knowledge on laminin 332 reorganization in OSCCs with special focus on its gamma 2 chain and provide, based on the current literature, evidence on its promising role as a grading and monitoring parameter and as a potential therapeutic target.

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“…PSMA3-AS1 can upregulate laminin subunit gamma 1 (LAMC1) to promote the proliferation and migration of cholangiocarcinoma ( 17 ). BBOX1-AS1 promotes the proliferation and metastasis of oral squamous cell carcinoma and inhibits apoptosis by upregulating laminin subunit gamma 2 (LAMC2) ( 18 ).…”

Section: Introductionmentioning

confidence: 99%

Prognostic significance and identification of basement membrane-associated lncRNA in bladder cancer

et al. 2022

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Based on the importance of basement membrane (BM) in cancer invasion and metastasis, we constructed a BM-associated lncRNA risk model to group bladder cancer (BCa) patients. Transcriptional and clinical data of BCa patients were downloaded from The Cancer Genome Atlas (TCGA), and the expressed genes of BM-related proteins were obtained from the BM-BASE database. We download the GSE133624 chip data from the GEO database as an external validation dataset. We screened for statistically different BM genes between tumors and adjacent normal tissues. Co-expression analysis of lncRNAs and differentially expressed BM genes was performed to identify BM-related lncRNAs. Then, differentially expressed BM-related lncRNAs (DEBMlncRNAs) between tumor and normal tissues were identified. Univariate/multivariate Cox regression analysis was performed to select lncRNAs for risk assessment. LASSO analysis was performed to build a prognostic model. We constructed a model containing 8 DEBMlncRNAs (AC004034.1, AL662797.1, NR2F1-AS1, SETBP1-DT, AC011503.2, AC093010.2, LINC00649 and LINC02321). The prognostic risk model accurately predicted the prognosis of BCa patients and revealed that tumor aggressiveness and distant metastasis were associated with higher risk scores. In this model, we constructed a nomogram to assist clinical decision-making based on clinicopathological characteristics such as age, T, and N. The model also showed good predictive power for the tumor microenvironment and mutational burden. We validated the expression of eight lncRNAs using the dataset GSE133624 and two human bladder cancer cell lines (5637, BIU-87) and examined the expression and cellular localization of LINC00649 and AC011503.2 using a human bladder cancer tissue chip. We found that knockdown of LINC00649 expression in 5637 cells promoted the proliferation of 5637 cells.Our eight DEBMlncRNA risk models provide new insights into predicting prognosis, tumor invasion, and metastasis in BCa patients.

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Long non-coding RNA BBOX1-antisense RNA 1 enhances cell proliferation and migration and suppresses apoptosis in oral squamous cell carcinoma via the miR-3940-3p/laminin subunit gamma 2 axis

Cited by 12 publications

References 45 publications

A review on the role of gamma-butyrobetaine hydroxylase 1 antisense RNA 1 in the carcinogenesis and tumor progression

A review on the role of gamma-butyrobetaine hydroxylase 1 antisense RNA 1 in the carcinogenesis and tumor progression

Invasion-Associated Reorganization of Laminin 332 in Oral Squamous Cell Carcinomas: The Role of the Laminin γ2 Chain in Tumor Biology, Diagnosis, and Therapy

Prognostic significance and identification of basement membrane-associated lncRNA in bladder cancer

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