Long non-coding RNA BANCR promotes proliferation and migration of lung carcinoma via MAPK pathways

Jiang, Wenjun; Zhang, Dandan; Xu, Baoning; Wu, Zhuo; Liu, Siyang; Zhang, Lei; Tian, Ye; Han, Xu; Tian, Dean

doi:10.1016/j.biopha.2014.11.027

Cited by 75 publications

(83 citation statements)

References 19 publications

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“…Reduced BANCR expression was associated with lymph node metastasis, advanced TNM stage, and shorter OS in patients with non-small cell lung cancer . Downregulation of BANCR obviously promoted growth, migration, and invasion and upregulation of BANCR significantly inhibited growth, migration, and invasion in lung cancer cell lines Jiang et al, 2015). Taken together, the role of BANCR in human malignancies may be multifaceted, depending on the tissue involved.…”

Section: Discussionmentioning

confidence: 95%

“…Both Jiang et al (2015) and showed decreased BANCR expression in lung cancer tissues and cells lines. Reduced BANCR expression was associated with lymph node metastasis, advanced TNM stage, and shorter OS in patients with non-small cell lung cancer .…”

Section: Discussionmentioning

confidence: 96%

“…Subsequently, aberrant BANCR expression was confirmed in papillary thyroid carcinoma , retinoblastoma (Su et al, 2015), lung cancer , Jiang et al, 2015, gastric cancer , and colorectal cancer . BANCR regulated cell proliferation, migration, and invasion in these tumors and thus may serve as a potential oncogene or candidate tumor suppressor.…”

Section: Introductionmentioning

confidence: 97%

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Increased expression of the lncRNA BANCR and its prognostic significance in human osteosarcoma

Zq¹,

R-B²,

Dm³

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Long noncoding RNAs (lncRNAs) play important roles in the formation and progression of many types of human malignancies. The aim of our study was to investigate the expression and biological functions of the lncRNA BRAF-activated noncoding RNA (BANCR) in human osteosarcoma. BANCR expression was quantified by real-time PCR in human osteosarcoma cell lines and tissues. We analyzed the association between BANCR levels and clinicopathological factors and patient prognosis. MTT, flow cytometric, and transwell invasion assays were performed to observe the effects of BANCR on MG-63 cell biological behaviors. BANCR overexpression was observed in osteosarcoma cell lines and clinical specimens. Increased BANCR expression was significantly associated with large tumor size, positive distant metastasis, and advanced clinical stage. High BANCR expression in osteosarcoma was an independent predictor of poor survival. Downregulation of BANCR inhibited MG-63 cell proliferation and invasion and promoted cell apoptosis in vitro. These findings suggested that BANCR may act as a tumor promoter in osteosarcoma and could serve as a potential therapeutic target for this disease.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 97%

See 1 more Smart Citation

Increased expression of the lncRNA BANCR and its prognostic significance in human osteosarcoma

Zq¹,

R-B²,

Dm³

et al. 2016

Genet. Mol. Res.

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“…It is frequently overexpressed and may be involved in the migration of melanoma cells (7). In non-small cell lung cancer, BANCR promotes the migration and invasion of cancer cells (8) through the mitogen-activated protein kinase (MAPK) signaling pathway. Epithelial-mesenchymal transition (EMT) refers to the process of transformation of epithelial cells to a mesenchymal cell phenotype, and serves an important function in tumor invasion and metastasis, since it may promote cancer cell migration and invasion (9,10).…”

Section: Introductionmentioning

confidence: 99%

lncRNA BANCR promotes EMT in PTC via the Raf/MEK/ERK signaling pathway

Wang

Lin

et al. 2018

Oncol Lett

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Abstract. Thyroid cancer is one of the most common types of cancer in the endocrine system. Among all types of thyroid cancer, papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Long non-coding RNA (lncRNA) BRAF-activated non-protein-coding RNA (BANCR) is a 688-bp-long nucleotide transcript, which was first identified in melanoma. The function of BANCR in thyroid cancer remains unclear. The aim of the present study was to investigate whether BANCR is involved in the development of thyroid cancer. The results indicated that BANCR expression was increased in thyroid tumors compared with in adjacent normal tissues. Among cancer cell lines, the expression level of BANCR differed: BANCR expression in BCPAP cell lines was lower compared with that in CAL-62, WRO and FTC-133 cell lines. Overexpression of BANCR promoted the migration and invasion of BCPAP cells. Additionally, BANCR mediated epithelial-mesenchymal transition (EMT) by regulating the expression of epithelial (E)-cadherin, vimentin and neuronal (N)-cadherin. Overexpression of BANCR in BCPAP cells decreased the expression of E-cadherin and increased the expression of vimentin, N-cadherin, phospho (p)-c-Raf, p-extracellular-signal-regulated kinase (ERK)/mitogen activated protein kinase (MEK)1/2 and p-ERK1/2. Administration of U0126 inhibitor inhibited the regulation of phosphorylation levels by MEK1/2 and ERK1/2. Additionally, U0126 upregulated the expression of E-cadherin and downregulated the expression of vimentin. Taken together, the results of the present study suggest that BANCR induces EMT in PTC through the Raf/MEK/ERK signaling pathway.

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“…The lncRNA UCA1 plays a key role in human bladder cancer growth and tumorigenesis; UCA1may have crucial biological activity and it may serve as a new therapeutic target for bladder cancer (25). The lncRNA BANCR has been found to offer potential as a diagnostic marker of lung cancer (26), Zfas1 offers potential as a marker of breast cancer (27), and TUG1 offers potential as a diagnostic marker of bladder cancer (28). In addition, the lncRNAs PVT1 (29), HULC (30), HEIH (31), ATB (32), DANCR (33), and LINC00152 (34) have been found to be dys-regulated in conditions like HCC.…”

Section: Introductionmentioning

confidence: 99%

The significance of low levels of LINC RP1130-1 expression in human hepatocellular carcinoma

Xiao

Wang

Cheng³

et al. 2016

BST

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Long non-coding RNA BANCR promotes proliferation and migration of lung carcinoma via MAPK pathways

Cited by 75 publications

References 19 publications

Increased expression of the lncRNA BANCR and its prognostic significance in human osteosarcoma

Increased expression of the lncRNA BANCR and its prognostic significance in human osteosarcoma

lncRNA BANCR promotes EMT in PTC via the Raf/MEK/ERK signaling pathway

The significance of low levels of LINC RP1130-1 expression in human hepatocellular carcinoma

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