Long Non-coding RNA BACE1-AS May Serve as an Alzheimer’s Disease Blood-Based Biomarker

Fotuhi, Seyedeh Nahid; Khalaj‐Kondori, Mohammad; Feizi, Mohammad Ali Hoseinpour; Talebi, Mahnaz

doi:10.1007/s12031-019-01364-2

Cited by 99 publications

(78 citation statements)

References 38 publications

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“…It has been reported that more than 10,000 lncRNAs are produced by human genomes; however, to date, little information related to lncRNAs, especially their function, have been established [24,25]. Recently, lncRNA has been found to be involved in some important regulatory processes, including transcriptional interference, transcriptional activation, and chromatin modification, and it may serve as a biomarker for various diseases, such as lung cancer [26], colorectal cancer [27], diabetes mellitus [28], and liver fibrosis [29].…”

Section: Discussionmentioning

confidence: 99%

Identification of lncRNA–miRNA–mRNA regulatory network associated with primary open angle glaucoma

Zhou

Tan

et al. 2020

BMC Ophthalmol

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Background: Primary open angle glaucoma (POAG) is a multifactorial disorder characterized by a progressive permanent degeneration of retinal ganglion cell (RGCs) death. An increasing number of studies have suggested that long noncoding RNAs (lncRNAs) have the ability to regulate gene expression; however, thus far, the mechanisms and functions of lncRNAs in the development of POAG are still unclear. Methods: Using the data from Gene Expression Omnibus (GEO), differentially expressed lncRNAs and differentially expressed mRNAs between POAG patients and controls were identified. Then, the lncRNA-miRNA-mRNA competing endogenous RNA (ceRNA) network was constructed, and the key lncRNAs in POAG were identified. A Gene Ontology (GO) analysis and a Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed to assess the enriched biological functions of mRNA in the ceRNA network. Results: During this study, a POAG-related ceRNA network with 37 miRNA nodes, 248 lncRNA nodes, 178 mRNA nodes, and 1985 edges was constructed. In addition, four lncRNAs (DNAJC27-AS1, AF121898, OIP5-AS1, and SNX29P2) were established as hub RNAs in this ceRNA network. The functional assay showed that 18 GO terms and 17 pathways were enriched. Conclusion: This study provides novel insights into the lncRNA-related ceRNA network in POAG, and the four lncRNAs were identified in the development of POAG.

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Section: Discussionmentioning

confidence: 99%

Identification of lncRNA–miRNA–mRNA regulatory network associated with primary open angle glaucoma

Zhou

Tan

et al. 2020

BMC Ophthalmol

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show abstract

Section: Discussionmentioning

confidence: 99%

Identification of lncRNA–miRNA–mRNA regulatory network associated with Primary Open Angle Glaucoma

Zhou

Tan

et al. 2020

Preprint

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Background Primary open angle glaucoma (POAG) is a complicated disorder characterized by a progressive permanent degeneration of retinal ganglion cell (RGCs) death. An increasing number of studies have suggested that long noncoding RNAs (lncRNAs) have the ability to regulate gene expression; however, thus far, the mechanisms and functions of lncRNAs in the development of POAG are still unclear. Methods Using the data from Gene Expression Omnibus (GEO), differentially expressed lncRNAs and differentially expressed mRNAs between POAG patients and controls were identified. Then, the lncRNA–miRNA–mRNA competing endogenous RNA (ceRNA) network was constructed, and the key lncRNAs in POAG were identified. A Gene Ontology (GO) analysis and a Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed to assess the enriched biological functions of mRNA in the ceRNA network. Results During this study, a POAG-related ceRNA network with 37 miRNA nodes, 248 lncRNA nodes, 178 mRNA nodes, and 1985 edges was constructed. In addition, four lncRNAs (DNAJC27-AS1, AF121898, OIP5-AS1, and SNX29P2) were established as hub RNAs in this ceRNA network. The functional assay showed that 18 GO terms and 17 pathways were enriched. Conclusion This study provides novel insights into the lncRNA-related ceRNA network in POAG, and the four lncRNAs were identified in the development of POAG.

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“…A conserved lncRNA called BACE1-antisense transcript (BACE1-AS) increases BACE1 mRNA stability and generates additional Aβ in AD patients as well as in APP transgenic mice, and knockdown of BACE1-AS improves memory (144,145). The BACE1-AS level differs significantly between pre-AD and healthy controls as well as full-AD and healthy controls, indicating that BACE1-AS may be a potential biomarker of AD (146). LncRNAs, including 51A, 17A, and NDM29, increase the formation of Aβ and contribute to the pathogenesis of AD (147).…”

Section: Non-coding Rnas In Admentioning

confidence: 99%

Epigenetics: Recent Advances and Its Role in the Treatment of Alzheimer's Disease

2020

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Long Non-coding RNA BACE1-AS May Serve as an Alzheimer’s Disease Blood-Based Biomarker

Cited by 99 publications

References 38 publications

Identification of lncRNA–miRNA–mRNA regulatory network associated with primary open angle glaucoma

Identification of lncRNA–miRNA–mRNA regulatory network associated with primary open angle glaucoma

Identification of lncRNA–miRNA–mRNA regulatory network associated with Primary Open Angle Glaucoma

Epigenetics: Recent Advances and Its Role in the Treatment of Alzheimer's Disease

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