Long Non-Coding RNA AL139385.1 as a Novel Prognostic Biomarker in Lung Adenocarcinoma

Chen, Xi; Guo, Jishu; Zhou, Fan; Ren, Wenjun; Huang, Xiaobin; Pu, Jun; Niu, Xiaoqun; Jiang, Xiulin

doi:10.3389/fonc.2022.905871

Cited by 4 publications

(1 citation statement)

References 38 publications

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“…The role of ceRNA networks is receiving increasing attention and has been reported in several complicated diseases, including carcinomas (Chen et al, 2022;Xiong et al, 2022), endometriosis , and tubal factor infertility (Li J. Z. et al, 2021a).…”

Section: Introductionmentioning

confidence: 99%

Construction of a ceRNA network in polycystic ovary syndrome (PCOS) driven by exosomal lncRNA

et al. 2022

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Polycystic ovary syndrome (PCOS), a common and frustrating syndrome in women of reproductive age, is characterized by symptoms including hyperandrogenemia, ovulation dysfunction, and polycystic ovaries. The role of competitive endogenous RNA (ceRNA) networks is receiving increasing attention and has been reported in multiple complicated diseases, such as various carcinomas, endometriosis, and tubal factor infertility. However, the association of ceRNA networks with the pathogenesis of PCOS remains unclear. This study aimed to construct a ceRNA network orchestrated by exosomal lnRNA and circRNA in PCOS. We screened RNA data of 34 samples from the Gene Expression Omnibus (GEO) database for differentially expressed lncRNAs (DELs), miRNAs (DEMs), mRNAs (DEGs), and circRNA associated with the progression of PCOS (PCOS, n = 17 vs. normal, n = 17). A protein–protein interaction (PPI) network, gene set enrichment analysis (GSEA), and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were conducted. Importantly, the function of the ceRNA network was explored using GO and KEGG enrichment analyses. We identified 46 DELs (25 upregulated and 21 downregulated), 31 DEMs (20 upregulated and 11 downregulated), 165 DEGs (52 upregulated and 113 downregulated), and 1 differentially expressed circRNA. The PPI network had 79 nodes and 112 edges. The GSEA results showed that these genes were mainly related to oxidative phosphorylation; TNF signaling pathways; and valine, leucine, and isoleucine degradation. GO and KEGG analyses revealed that the DEGs were significantly enriched in lipid metabolism, peroxisome proliferator-activated receptor (PPAR) signaling pathways, and fatty acid metabolism. Additionally, we constructed a novel PCOS-associated lncRNA–miRNA–mRNA ceRNA triple network and a circRNA-related network. Thereafter, we described the potential roles played by follicular fluid exosomes in PCOS. Our present study describes the molecular pathogenesis of PCOS in human ovarian granulosa cells at the post-transcriptional level, which provides new insights for the clinical diagnosis and treatment of PCOS and further scientific research.

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Section: Introductionmentioning

confidence: 99%

Construction of a ceRNA network in polycystic ovary syndrome (PCOS) driven by exosomal lncRNA

et al. 2022

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Non-coding RNA regulation of integrins and their potential as therapeutic targets in cancer

2022

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Background Integrins are integral to cell signalling and management of the extracellular matrix, and exquisite regulation of their expression is essential for a variety of cell signalling pathways, whilst disordered regulation is a key driver of tumour progression and metastasis. Most recently non-coding RNAs in the form of micro-RNA (miRNA) and long non-coding RNA (lncRNA) have emerged as a key mechanism by which tissue dependent gene expression is controlled. Whilst historically these molecules have been poorly understood, advances in ‘omic’ technologies and a greater understanding of non-coding regions of the genome have revealed that non-coding RNAs make up a large proportion of the transcriptome. Conclusions and Perspectives This review examines the regulation of integrin genes by ncRNAs, provides and overview of their mechanism of action and highlights how exploitation of these discoveries is informing the development of novel chemotherapeutic agents in the treatment of cancer. MiRNA molecules have been the most extensively characterised and negatively regulate most integrin genes, classically regulating genes through binding to recognition sequences in the mRNA 3′-untranslated regions of gene transcripts. LncRNA mechanisms of action are now being elucidated and appear to be more varied and complex, and may counter miRNA molecules, directly engage integrin mRNA transcripts, and guide or block both transcription factors and epigenetic machinery at integrin promoters or at other points in integrin regulation. Integrins as therapeutic targets are of enormous interest given their roles as oncogenes in a variety of tumours, and emerging therapeutics mimicking ncRNA mechanisms of action are already being trialled.

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Exosomal EIF5A derived from Lewis lung carcinoma induced adipocyte wasting in cancer cachexia

Xiong,

Ye,

Luo

et al. 2023

Cellular Signalling

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Long Non-Coding RNA AL139385.1 as a Novel Prognostic Biomarker in Lung Adenocarcinoma

Cited by 4 publications

References 38 publications

Construction of a ceRNA network in polycystic ovary syndrome (PCOS) driven by exosomal lncRNA

Construction of a ceRNA network in polycystic ovary syndrome (PCOS) driven by exosomal lncRNA

Non-coding RNA regulation of integrins and their potential as therapeutic targets in cancer

Exosomal EIF5A derived from Lewis lung carcinoma induced adipocyte wasting in cancer cachexia

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