Abstract:RATIONALE: Innate immune abnormalities and mitochondrial dysfunction are frequently reported in ASD subjects, indicating a possible association between immune-mediated inflammation and mitochondrial dysfunction in ASD. METHODS: Inflammatory cytokine such as IL-1ß generated by innate immune cells affect mitochondrial functions. In 71 ASD subjects, cytokine production by purified peripheral blood monocytes (PB Mo) and mitochondrial function measured as oxygen consumption rate (OCR) in peripheral blood mononuclea… Show more
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