Long lasting protection against canine kala-azar using the FML-QuilA saponin vaccine in an endemic area of Brazil (S�o Gon�alo do Amarante, RN)

Borja-Cabrera, G.P.

doi:10.1016/s0264-410x(02)00294-3

Cited by 172 publications

(170 citation statements)

References 29 publications

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“…A multidisciplinary group of researchers have long been studying the FML-vaccine 7,46 . A field study in a LV-endemic area of Rio Grande do Norte State showed that this vaccine induced a significant long lasting and strong protective effect against canine visceral leishmaniasis 7 .…”

Section: Canine Vaccination: a Current Discussionmentioning

confidence: 99%

“…A field study in a LV-endemic area of Rio Grande do Norte State showed that this vaccine induced a significant long lasting and strong protective effect against canine visceral leishmaniasis 7 . These studies also demonstrated that almost all vaccinated dogs presented detectable antibodies against Leishmania antigens and, at the moment, there is no way to distinguish antibodies developed due to natural infection from those developed due to vaccination.…”

Section: Canine Vaccination: a Current Discussionmentioning

confidence: 99%

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Visceral leishmaniasis in Brazil: revisiting paradigms of epidemiology and control

Dantas‐Torres

Brandão-Filho

2006

Rev. Inst. Med. trop. S. Paulo

167

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SUMMARYIn the last 20 years, despite the known underestimation of cases, Brazil registered a marked increase in the incidence of visceral leishmaniasis. The main goal of this review is to reflect on some aspects of this zoonosis in Brazil and also to encourage the discussion in order to find more viable, effective and affordable strategies to be implemented by the Brazilian Leishmaniasis Control Program. The current situation of visceral leishmaniasis in Brazil might be seen as a paradox: the most important aspects of the disease are known, but so far the control of this disease has not yet been achieved. The current control strategies have not been able to prevent the geographical expansion, and even a rise in the incidence and lethality of visceral leishmaniasis. There is a need not only for a better definition of priority areas, but also for the implementation of a fieldwork monitoring system to the disease surveillance that could permit a further evaluation of the control program in areas where visceral leishmaniasis is endemic.

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Section: Canine Vaccination: a Current Discussionmentioning

confidence: 99%

Section: Canine Vaccination: a Current Discussionmentioning

confidence: 99%

Visceral leishmaniasis in Brazil: revisiting paradigms of epidemiology and control

Dantas‐Torres

Brandão-Filho

2006

Rev. Inst. Med. trop. S. Paulo

167

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“…Uma nova vacina desenvolvida na Universidade Federal do Rio de Janeiro, e já testada em campo, foi capaz de proteger 92-95% dos cães vacinados contra LV 59 . Considerada uma vacina de segunda geração, a vacina FML, com o aval do Ministério da Agricultura, Pecuária e Abastecimento, está sendo industrializada e comercializada com o nome de Leishmune, pela Fort Dodge® Saúde Animal a partir de 2004.…”

Section: Tratamento Tratamento Tratamento Tratamento Tratamentounclassified

Leishmaniose visceral no Brasil: quadro atual, desafios e perspectivas

Gontijo

Melo

2004

Rev. bras. epidemiol.

367

197

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No Brasil, a importância da leishmaniose visceral reside não somente na sua alta incidência e ampla distribuição, mas também na possibilidade de assumir formas graves e letais quando associada ao quadro de má nutrição e infecções concomitantes. A crescente urbanização da doença ocorrida nos últimos 20 anos coloca em pauta a discussão das estratégias de controle empregadas. Neste artigo foram analisados os principais aspectos biológicos, ambientais e sociais que influenciaram no processo de expansão e urbanização dos focos da doença. Os métodos disponíveis para o diagnóstico e tratamento não apresentam a eficácia e aplicabilidade desejadas, embora avanços promissores tenham sido alcançados com as pesquisas de novos testes diagnósticos e drogas terapêuticas. As medidas de controle da doença até agora implementadas foram incapazes de eliminar a transmissão e impedir a ocorrência de novas epidemias. É feita uma breve análise destas medidas e dos desafios a serem enfrentados. A prevenção da doença nos cães através da imunoprofilaxia aparece como uma alternativa para o controle. Uma nova vacina para cães, já testada em campo, está sendo industrializada e será comercializada no Brasil a partir de 2004. Apesar da existência de inúmeros estudos sobre a leishmaniose visceral humana e canina, muitas lacunas ainda precisam ser preenchidas.

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“…However, current treatment regimens for CVL are not fully effective for eradicating these parasites [28]. A commercial vaccine against CVL [5], is available in parts of South America but not in the Old World.…”

Section: Zoonotic Visceral Leishmaniasis (Zvl) Is Caused By Parasitesmentioning

confidence: 99%

Splenic immune responses during canine visceral leishmaniasis

Strauss-Ayali

Baneth

Jaffe³

2007

Vet. Res.

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-Dogs are the main reservoir host for zoonotic visceral leishmaniasis caused by Leishmania infantum. In this study we investigated the immune response in spleens of L. infantum-infected dogs by measuring the mRNA expression levels for a wide panel of cytokines, transcription factors and chemokines. mRNA levels and parasite load were followed during 7 months of experimental infection and 14 months post-treatment, and were compared to naturally-infected (NI) dogs. Similarly, serum anti-Leishmania IgG and IgG subclass levels were measured during experimental infection. An increase in IFN-γ, T-bet, IP-10 and RANTES was found in the experimentally and NI dogs, implicating a substantial type-1 immune response during canine visceral leishmaniasis. IL-4, a type-2 associated cytokine, increased as early as one month after experimental infection, while IL-5 was high at later stages. Interestingly, the expression levels of the Treg-associated cytokines, IL-10 and TGF-β, did not change during the infection. Total anti-Leishmania IgG and IgG subclasses increased during the experimental infection. However, no association with specific cytokine patterns was observed. Parasite load in the spleens increased as early as one month postinfection and remained high until treatment. The load was higher in the polysymptomatic NI dogs than in the experimentally-infected dogs. This study indicates that both type-1 and type-2 immune responses occur in the spleen during canine L. infantum infection, and suggests that the early elevation of IL-4 might have a role in the persistence of parasites in the presence of high IFN-γ expression.canine visceral leishmaniasis / IFN-γ / IL-4 / T-bet / IP-10

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Long lasting protection against canine kala-azar using the FML-QuilA saponin vaccine in an endemic area of Brazil (S�o Gon�alo do Amarante, RN)

Cited by 172 publications

References 29 publications

Visceral leishmaniasis in Brazil: revisiting paradigms of epidemiology and control

Visceral leishmaniasis in Brazil: revisiting paradigms of epidemiology and control

Leishmaniose visceral no Brasil: quadro atual, desafios e perspectivas

Splenic immune responses during canine visceral leishmaniasis

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