Long-lasting potentiation of synaptic potentials in the motor cortex produced by stimulation of the sensory cortex in the cat: a basis of motor learning

Sakamoto, Takashi; Porter, Linda; Asanuma, Hiroshi

doi:10.1016/0006-8993(87)91029-8

Cited by 135 publications

(58 citation statements)

References 23 publications

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“…The functional properties of M1 neurons are strongly influenced by somatosensory feedback (Lemon and Porter, 1976;Zarzecki, 1989), and stimulation-evoked output from M1 can change on readjustments of limb position, a manipulation that presumably changes proprioceptive feedback (Gellhorn and Hyde, 1953;Sanes et al, 1992). Corresponding parts of representational maps in S1 and M1 are topographically linked by dense corticocortical connections (Jones et al, 1978;Izraeli and Porter, 1995); such connectivity is critical for learning new motor skills (Pavlides et al, 1993) and can display activity-dependent changes in functional efficacy (Sakamoto et al, 1987). The close functional and anatomical relationship between motor and somatosensory cortical maps raises the possibility that the influence of tactile experience on developing representational maps in S1 extends to those of developing motor cortex.…”

Section: Abstract: Motor Cortex; Rat; Vibrissa; Plasticity; Developmmentioning

confidence: 99%

Differential Effects of Abnormal Tactile Experience on Shaping Representation Patterns in Developing and Adult Motor Cortex

Huntley

1997

J. Neurosci.

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This study investigates the influence of early somatosensory experience on shaping movement representation patterns in motor cortex. Electrical microstimulation was used to map bilaterally the motor cortices of adult rats subjected to altered tactile experience by unilateral vibrissa trimming from birth (birth-trimmed group) or for comparable periods that began in adulthood (adult-trimmed group). Findings demonstrated that (1) vibrissa trimming from birth, but not when initiated in adulthood, led to a significantly smaller-sized primary motor cortex (M1) vibrissa representation in the hemisphere contralateral to the trimmed vibrissae, with no evidence for concomitant changes in size of the adjacent forelimb representation or the representation of the intact vibrissae in the opposite (ipsilateral) hemisphere; (2) in the contralateral hemispheres of the birthtrimmed group, an abnormal pattern of evoked vibrissa movement was evident in which bilateral or ipsilateral (intact) vibrissa movement predominated; (3) in both hemispheres of the birthtrimmed group, current thresholds for eliciting movement of the trimmed vibrissa were significantly lower than normal; and (4) in the adult-trimmed group, but not in the birth-trimmed group, there was a decrease bilaterally in the relative frequency of dual forelimb-vibrissa sites that form the common border between these representations. These results show that sensory experience early in life exerts a significant influence in sculpting motor representation patterns in M1. The mature motor cortex is more resistant to the type and magnitude of influence that tactile experience has on developing M1, which may indicate that such an influence is constrained by a developmentally regulated critical period.

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Section: Abstract: Motor Cortex; Rat; Vibrissa; Plasticity; Developmmentioning

confidence: 99%

Differential Effects of Abnormal Tactile Experience on Shaping Representation Patterns in Developing and Adult Motor Cortex

Huntley

1997

J. Neurosci.

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“…There are extensive and somatotopic connections between S1 and M1 directly targeting layer V pyramidal tract neurons (Porter, 1996) or relaying in MI cortical layers II/III (Kaneko et al , 1994). It is also known that tetanic stimulation of S1 produces long-term potentiation in layers II/III of M1 (Sakamoto et al , 1987, Keller et al , 1990) (Sakamoto et al, 1987, Keller et al, 1990. This could represent one pathway whereby HF-RSS might somatotopically increase excitability of the M1 GABAergic interneurons involved in SICI (Kujirai et al , 1993).…”

Section: Hf-rss Effects On Motor Cortex Inhibitionmentioning

confidence: 99%

High frequency somatosensory stimulation increases sensori-motor inhibition and leads to perceptual improvement in healthy subjects

Rocchi

Erro

Antelmi

et al. 2017

Clinical Neurophysiology

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Objective: high frequency repetitive somatosensory stimulation (HF-RSS), which is a patterned electric stimulation applied to the skin through surface electrodes, improves two-point discrimination, somatosensory temporal discrimination threshold (STDT) and motor performance in humans.However, the mechanisms which underlie this changes are still unknown. In particular, we hypothesize that refinement of inhibition might be responsible for the improvement in spatial and temporal perception. Methods: fifteen healthy subjects underwent 45 minutes of HF-RSS. Before and after the intervention several measures of inhibition in the primary somatosensory area (S1), such as paired-pulse somatosensory evoked potentials (pp-SEP), high-frequency oscillations (HFO), and STDT were tested, as well as tactile spatial acuity and short intracortical inhibition (SICI). Results:HF-RSS increased inhibition in S1 tested by pp-SEP and HFO; these changes were correlated with improvement in STDT. HF-RSS also enhanced bumps detection, while there was no change in grating orientation test. Finally there was an increase in SICI, suggesting widespread changes in cortical sensorimotor interactions. Conclusions: these findings suggest that HF-RSS can improve spatial and temporal tactile abilities by increasing the effectiveness of inhibitory interactions in the somatosensory system. Moreover, HF-RSS induces changes in cortical sensorimotor interaction.Significance: HF-RSS is a repetitive electric stimulation technique able to modify the effectiveness of inhibitory circuitry in the somatosensory system and primary motor cortex. 4

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“…This associative property of LTP as well as its long duration have made it an attractive model for memory storage and learning. LTP has also been demonstrated in several regions outside the hippocampus (Artola & Singer, 1987;Baranyi & Szente, 1987;Bindman, Meyer & Pockett, 1987;Sakamoto, Porter, & Asanuma, 1987;Perkins & Teyler, 1988;Racine, Milgram & Hafner, 1983;Komatsu, Fujii, Maeda, Sakaguchi, & Toyama, 1988;Rasmusson & Dykes, 1988;Stripling, Patneau & Gramlich, 1988;Sutor & Hablitz, 1989a, b). Although some of the properties of LTP in these regions resemble that seen in the hippocampus, the mechanisms involved are poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Mechanisms underlying potentiation of synaptic transmission in rat anterior cingulate cortex in vitro.

Sah

Nicoll

1991

The Journal of Physiology

112

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SUMMARY1. The properties of the excitatory synapse made by callosal inputs onto layer V and layer VI cells in the anterior cingulate cortex were studied in an in vitro slice preparation with intracellular recording.2. In the presence of picrotoxin, the excitatory postsynaptic potential (EPSP) had two components, a fast component blocked by the non-N-methyl-D-aspartate (NMDA) receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and a slow component blocked by the NMDA receptor antagonist DL-2-amino-5-phosphonovalerate (APV).3. Delivery of a brief tetanus to the afferent fibres led to a long-term potentiation (LTP) of the initial slope of the monosynaptic EPSP. The LTP displayed the property of co-operativity and could be blocked by APV or by buffering intracellular calcium.4. Pairing of low frequency presynaptic activity or weak tetanic stimulation with postsynaptic depolarization failed to potentiate the EPSP. This suggests that postsynaptic depolarization alone is unable to explain the co-operativity.5. It is concluded that the transmitter mediating the excitatory input between callosal afferents and layer V and layer VI pyramidal neurones is glutamate. Tetanic stimulation of these afferents leads to LTP which shares many but not all the properties of LTP seen in the CAI region of the hippocampus.

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Long-lasting potentiation of synaptic potentials in the motor cortex produced by stimulation of the sensory cortex in the cat: a basis of motor learning

Cited by 135 publications

References 23 publications

Differential Effects of Abnormal Tactile Experience on Shaping Representation Patterns in Developing and Adult Motor Cortex

Differential Effects of Abnormal Tactile Experience on Shaping Representation Patterns in Developing and Adult Motor Cortex

High frequency somatosensory stimulation increases sensori-motor inhibition and leads to perceptual improvement in healthy subjects

Mechanisms underlying potentiation of synaptic transmission in rat anterior cingulate cortex in vitro.

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