Long-lasting delayed hyperalgesia after chronic restraint stress in rats—effect of morphine administration

Torres, Iraci Lucena da Silva; Cucco, Simone N.S; Bassani, Marcio Garcia; Duarte, Marcelo S; Silveira, Patrícia Pelufo; Vasconcellos, Ana Paula Santana de; Tabajara, Angela Sampaio; Dantas, Giovana; Fontella, Fernanda U.; Dalmaz, Carla; Ferreira, Maria Beatriz Cardoso

doi:10.1016/s0168-0102(02)00232-8

Cited by 107 publications

(56 citation statements)

References 45 publications

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“…This profile is in concordance with previous studies, which indicate a weak effect of enrichment on behavioral and physiological parameters in 'naïve' animals (van Praag et al, 2000;Schrijver et al, 2002). On the basis of the present data, we would suggest that lower anxiety in VPA rats subjected to environmental enrichment in the early stage of life may conduct to increased exploration, normalized locomotor and repetitive/stereotypic activity, and attenuated nociceptive and tactile thresholds, as fear and anxiety have profound influence on these parameters in animals (eg King et al, 2003;da Silva Torres et al, 2003;Palermo-Neto et al, 2003;Knott and Hutson, 1982). Enhanced repetitive/ stereotypic-like activity is associated with many neurodevelopmental disorders in humans (eg autism), and often observed under conditions of environmental restriction in animals.…”

Section: Discussionsupporting

confidence: 92%

Environmental Enrichment Reverses Behavioral Alterations in Rats Prenatally Exposed to Valproic Acid: Issues for a Therapeutic Approach in Autism

Schneider

Turczak

Przewłocki

2005

Neuropsychopharmacol

249

155

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Environmental enrichment has been repeatedly shown to affect multiple aspects of brain function, and is known to improve cognitive, behavioral, and histopathological outcome after brain injuries. The purpose of the present experiments was to determine the effect of an enriched environment on behavioral aberrations observed in male rats exposed to valproic acid on day 12.5 of gestation (VPA rats), and proposed on the basis of etiological, anatomical, and behavioral data as an animal model of autism. Environmental enrichment reversed almost all behavioral alterations observed in the model. VPA rats after environmental enrichment (VPA-E) compared to VPA rats reared in standard conditions have higher sensitivity to pain and lower sensitivity to nonpainful stimuli; stronger acoustic prepulse inhibition; lower locomotor, repetitive/stereotypic-like activity, and enhanced exploratory activity; decreased anxiety; increased number of social behaviors; and shorter latency to social explorations. In comparison with control animals (Con), VPA-E rats exhibited increased number of pinnings in adolescence and social explorations in adulthood, and were less anxious in the elevated plus maze. Similar differences in social behavior and anxiety were observed between control rats exposed to environmental enrichment (Con-E) and control group reared in standard conditions. These results suggest that postnatal environmental manipulations can counteract the behavioral alterations in VPA rats. We propose environmental enrichment as an important tool for the treatment of autism spectrum disorders.

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Section: Discussionsupporting

confidence: 92%

Environmental Enrichment Reverses Behavioral Alterations in Rats Prenatally Exposed to Valproic Acid: Issues for a Therapeutic Approach in Autism

Schneider

Turczak

Przewłocki

2005

Neuropsychopharmacol

249

155

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“…This latter observation associated with the fact that, in defeated intruders, 6 mg/kg morphine did not produce an analgesic effect significantly different from that induced by 4 mg/kg, strongly suggests that morphine did not prevent hyperalgesia resulting from the anxiety generated by the experimental procedure of social defeat. To our knowledge, only one recent paper has demonstrated that, in repeatedly stressed animals, morphine effects on nociception were decreased when compared with unstressed controls (da Silva Torres et al, 2003). Because pretreatment with 2 mg/kg morphine produced a partial analgesic effect during interphase and phase II and because 6 mg/kg morphine was not more efficient than 4 mg/kg, the following studies were performed with 4 mg/kg morphine.…”

Section: Discussionmentioning

confidence: 99%

“…However, exposure to powerful acute stressors does not model the situation faced by clinicians dealing with pain in anxious or depressed patients. Studies of chronic stress suggest that stress can produce hyperalgesia rather than hypoalgesia (Gamaro et al, 1998;Quintero et al, 2000;Butkevich and Vershinina, 2001;da Silva Torres et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Involvement of Cholecystokininergic Systems in Anxiety-Induced Hyperalgesia in Male Rats: Behavioral and Biochemical Studies

André¹,

Zeau²,

Pohl³

et al. 2005

J. Neurosci.

107

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“…Among various CNS systems involved in producing stressinduced analgesia (SIA), endogenous opioids play a critical role (Akil et al, 1976;Lewis et al, 1980). However, hyperalgesia following stress has also been reported in animals (Vidal and Jacob, 1982) especially when stress is repeated for a long time (Satoh et al, 1992;da Silva Torres et al, 2003;Bradesi et al, 2005;Khasar et al, 2005;Gameiro et al, 2006). Unlike SIA, the mechanisms involved in stressinduced hyperalgesia (SIH) are poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Non-Nociceptive Environmental Stress Induces Hyperalgesia, Not Analgesia, in Pain and Opioid-Experienced Rats

Rivat¹,

Laboureyras²,

Laulin

et al. 2007

Neuropsychopharmacol

120

116

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It is well admitted that stress induces analgesia (SIA) via endogenous opioid release. However, there is evidence that stressful events play a role in the pathogenesis of pain, but little is known about mechanisms underlying such pain vulnerability. Previous studies reported that a single opioid exposure activates NMDA-dependent pronociceptive systems leading to long-term pain vulnerability after analgesia. Here, we studied whether prior inflammatory pain or/and opioid experiences may favour the development of pain vulnerability after nonnociceptive environmental stress (NNES). Nociceptive threshold (NT) changes were evaluated by paw pressure vocalization test. By contrast to discrete SIA observed in naive rats, 1 h stress induced hyperalgesia (SIH) for several hours (15-65% NT decrease) in pain and opioid experienced rats. Repetition of NNES induced an 18-to 22-fold SIH enhancement (3-4 days), whereas SIA decreased. SIH was still observed 4 months after pain and opioid experiences. This phenomenon is referred to as latent pain sensitization. Furthermore, a fentanyl ultra-low dose (ULD, 50 ng/kg) administration, mimicking SIA in naive rats, induced hyperalgesia (65% NT decrease, 4 h), not analgesia, in pain and opioid-experienced rats. This indicates that low levels of opioids induce opposite effects, that is analgesia vs hyperalgesia dependent on prior life events. In pain and opioid-experienced rats, NMDA receptor antagonists, ketamine or BN2572, completely prevented hyperalgesia when injected just before NNES or fentanyl ULD. This latent pain sensitization model may be important for studying the transition from acute to chronic pain and individual differences in pain vulnerability associated with prior life events.

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Long-lasting delayed hyperalgesia after chronic restraint stress in rats—effect of morphine administration

Cited by 107 publications

References 45 publications

Environmental Enrichment Reverses Behavioral Alterations in Rats Prenatally Exposed to Valproic Acid: Issues for a Therapeutic Approach in Autism

Environmental Enrichment Reverses Behavioral Alterations in Rats Prenatally Exposed to Valproic Acid: Issues for a Therapeutic Approach in Autism

Involvement of Cholecystokininergic Systems in Anxiety-Induced Hyperalgesia in Male Rats: Behavioral and Biochemical Studies

Non-Nociceptive Environmental Stress Induces Hyperalgesia, Not Analgesia, in Pain and Opioid-Experienced Rats

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