Long-lasting changes in stress-induced corticosterone response and anxiety-like behaviors as a consequence of neonatal maternal separation in Long–Evans rats

Early-Life Immune Challenge: Defining a Critical Window for Effects on Adult Responses to Immune Challenge

“…Further evidence for this is that maternal behavior has been shown to be critical for adult emotionality in rats. For instance, separation from the mother has been shown to alter responses in behavioral tests of anxiety including the elevated plus maze (Daniels et al, 2004;Kalinichev et al, 2002). As we saw no significant differences in the anxiety responses elicited by the elevated plus maze in the present study, it is unlikely that there were marked differences in maternal behavior directed towards LPS-or saline-injected pups.…”

The arcuate NPY, POMC, and CART expressions responding to food deprivation are exaggerated in young female rats that experienced neonatal maternal separation

“…3 h of daily MS during the first two weeks of birth, have reported that weight gain of MS females does not differ from NH females until 2 months of age, except a transient increase shortly after the separation period (Kalinichev et al, 2002;Slotten et al, 2006;Maniam and Morris, 2010). It appears that neonatal maternal separation acutely, but not permanently, affects body weight gain of the offspring as long as the littermates are housed in group with ad libitum access to food (Mclntosh et al, 1999;Iwasaki et al, 2000;Kalinichev et al, 2002;Kim et al, 2005;Slotten et al, 2006;Maniam and Morris, 2010).…”

The impact of early postnatal environmental enrichment on maternal care and offspring behaviour following weaning

“…By contrast, longer periods of separation caused long lasting, anxiogenic, i.e. detrimental effects in the offspring (Huot et al 2001;Kalinichev et al 2002;Daniels et al 2004). …”