Long-lasting behavioral effects and recognition memory deficit induced by chronic mild stress in mice: effect of antidepressant treatment

Elizalde, N.; Gil-Bea, Francisco J.; Ramírez, M. J.; Aisa, Bárbara; Lasheras, B.; Rı́o, Joaquı́n Del; Tordera, Rosa M.

doi:10.1007/s00213-007-1035-1

Cited by 170 publications

(146 citation statements)

References 86 publications

(128 reference statements)

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“…Recent animal studies with the inverse agonist selective for α5 GABA-A receptors found improved learning and memory function in models of cognitive defect, suggesting distinctive roles of different subunits [25]. The antidepressant and memory-enhancing effects are in agreement with observations that low mood is frequently combined with anxiety and cognitive impairment [26]. A recently found correlation between helpless behavior and cognition [26,27] was fully supported by our results demonstrating that the antidepresant-like effect was obtained by the same selective agent (L-655,708) that previously induced memory-enhancing effects.…”

Section: Discussionsupporting

confidence: 78%

Antidepressant effects of an inverse agonist selective for α5 GABA-A receptors in the rat forced swim test

Samardžić¹,

Puškaš²,

Obradović³

et al. 2014

Acta Veterinaria

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It has been shown in electrophysiological studies that the ligand L-655,708 possesses a binding selectivity and a moderate inverse agonist functional selectivity for α5-containing GABA-A receptors. The present study is aimed to investigate the antidepressant effects of the ligand L-655,708 in the forced swim test (FST) and its impact on locomotor activity in rats. The behavior of the animals was recorded with a digital camera, and the data were analyzed by one-way ANOVA, followed by Dunnett’s test. In FST, L-655,708 significantly decreased immobility time at a dose of 3 mg/kg after a single and repeated administration (p<0.05), exerting acute and chronic antidepressant effects. However, it did not induce significant differences in the time of struggling behavior during FST. Furthermore, L-655,708 did not show a significant effect on locomotor activity (p>0.05). These data suggest that negative modulation at GABA-A receptors containing the α5 subunit may produce antidepressant effects in rats. These effects were not confounded by locomotor influences.

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Section: Discussionsupporting

confidence: 78%

Antidepressant effects of an inverse agonist selective for α5 GABA-A receptors in the rat forced swim test

Samardžić¹,

Puškaš²,

Obradović³

et al. 2014

Acta Veterinaria

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“…The paroxetine dose was chosen based on previous studies (Da-Rocha et al, 1997;Hascoët et al, 2000a, b;Massé et al, 2005;Elizalde et al, 2008;Thoeringer et al, 2010).…”

Section: Specificity Of the Induced Social Fearmentioning

confidence: 99%

Social Fear Conditioning: A Novel and Specific Animal Model to Study Social Anxiety Disorder

Toth

Neumann

Slattery

2012

Neuropsychopharmacol

125

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Social anxiety disorder (SAD) is a major health concern with high lifetime prevalence. The current medication is rather unspecific and, despite considerable efforts, its efficacy is still unsatisfactory. However, there are no appropriate and specific animal models available to study the underlying etiology of the disorder. Therefore, we aimed to establish a model of specific social fear in mice and use this social fear conditioning (SFC) model to assess the therapeutic efficacy of the benzodiazepine diazepam and of the antidepressant paroxetine; treatments currently used for SAD patients. We show that by administering electric foot shocks (2-5, 1 s, 0.7 mA) during the investigation of a con-specific, the investigation of unfamiliar con-specifics was reduced for both the short-and long-term, indicating lasting social fear. The induced fear was specific to social stimuli and did not lead to other behavioral alterations, such as fear of novelty, general anxiety, depression, and impaired locomotion. We show that social fear was dose-dependently reversed by acute diazepam, at doses that were not anxiolytic in a non-social context, such as the elevated plus maze. Finally, we show that chronic paroxetine treatment reversed social fear. All in all, we demonstrated robust social fear after exposure to SFC in mice, which was reversed with both acute benzodiazepine and chronic antidepressant treatment. We propose the SFC model as an appropriate animal model to identify the underlying etiology of SAD and possible novel treatment approaches.

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“…Unpredictable repeated mild stressors were applied for six weeks (23). In the first experiment CMS was applied to WT and VGLUT+/-mice (n=15 mice/group) and both control and stressed mice were sacrificed 24 h after the termination of CMS.…”

Section: Chronic Mild Stress (Cms) Proceduresmentioning

confidence: 99%

“…Visual recognition memory was assessed by this test (23). The apparatus consisted of a black square arena (43 x 50 x 45 cm).…”

Section: Novel Object Recognitionmentioning

confidence: 99%

Increased Vulnerability to Depressive-Like Behavior of Mice with Decreased Expression of VGLUT1

Garcia-García

Elizalde

Matrov

et al. 2009

Biological Psychiatry

113

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Long-lasting behavioral effects and recognition memory deficit induced by chronic mild stress in mice: effect of antidepressant treatment

Abstract: CMS leads to a long-term altered behavioral profile that could be partially reverted by chronic antidepressant treatment. This study brings novel features regarding the long-term effects of CMS and on the predictive validity of this depression animal model.

Cited by 170 publications

References 86 publications

Antidepressant effects of an inverse agonist selective for α5 GABA-A receptors in the rat forced swim test

Antidepressant effects of an inverse agonist selective for α5 GABA-A receptors in the rat forced swim test

Social Fear Conditioning: A Novel and Specific Animal Model to Study Social Anxiety Disorder

Increased Vulnerability to Depressive-Like Behavior of Mice with Decreased Expression of VGLUT1

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