Long-Lasting, Antinociceptive Effects of pH-Sensitive Niosomes Loaded with Ibuprofen in Acute and Chronic Models of Pain

Marzoli, Francesca; Marianecci, Carlotta; Rinaldi, Federica; Passeri, Daniele; Rossi, M.; Minosi, Paola; Carafa, Maria; Pieretti, Stefano

doi:10.3390/pharmaceutics11020062

Cited by 17 publications

(11 citation statements)

References 40 publications

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“…There are several reports on the anti-inflammatory activity of niosomes or proniosomes and their pharmacological effects [29,63,64]. Akbari et al studied the anti-inflammatory effect of curcumin loaded niosomes and revealed a higher anti-inflammatory and antinociceptive activity of the curcumin niosome formulation in the formalin test [29].…”

Section: Formalin Testmentioning

confidence: 99%

Innovative topical niosomal gel formulation containing diclofenac sodium (niofenac)

Âkbari

Saeedi

Morteza‐Semnani

et al. 2021

Journal of Drug Targeting

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The purpose of this research was to enhance the transdermal delivery of diclofenac sodium niosomal formulations. To characterise the obtained niosomes, SEM, XRPD, DSC and ATR-FTIR were employed. The size of the niosomes increased from 158.00±6.17 to 400.87±4.99 nm when cholesterol was incorporated into the formulations. It was observed that the zeta potential of niofenac varies from -25.40±1.352 to -43.13±1.171 mV when the cholesterol percentage decreased from 2% to 0.2%. The higher entrapment efficiency percentage (63.70±0.18%) was obtained for the formulations with larger particle sizes and higher cholesterol content. The optimised niofenac formulation showed a controlled release fashion where 61.71±0.59% of the drug released within 24 h. The results showed that the value of permeated diclofenac sodium through the skin layers was higher for the niofenac gel formulation (242.3±31.11 µg/cm 2 ) compared to simple gel formulation (127.40±27.80 µg/cm 2 ). Besides, niofenac formulation outperformed the anti-inflammatory activities in the formalin test compared to the control and diclofenac simple gel group. The licking time was significantly lower in both early (40.2±7.3 s) and late stages (432.4±31.7 s) for niofenac compared to conventional formulation (early stage 130.4±8.73 s and late stage 660.6±123.73 s). This study indicates that niosomal formulations can improve drug therapeutic effects by increasing drug delivery to specific sites.

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Section: Formalin Testmentioning

confidence: 99%

Innovative topical niosomal gel formulation containing diclofenac sodium (niofenac)

Âkbari

Saeedi

Morteza‐Semnani

et al. 2021

Journal of Drug Targeting

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“…IBU, a typical nonsteroidal anti-inflammatory drug, is broadly exploited to treat pain, fever and inflammation. However, its poor water solubility always limits its fast action for achieving a desired therapeutic effect [46,47,48]. HPMC is commonly utilized as an excipient in oral tablet, eye drops, and capsule formations.…”

Section: Introductionmentioning

confidence: 99%

The Process–Property–Performance Relationship of Medicated Nanoparticles Prepared by Modified Coaxial Electrospraying

Huang

Hou

et al. 2019

Pharmaceutics

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In pharmaceutical nanotechnology, the intentional manipulation of working processes to fabricate nanoproducts with suitable properties for achieving the desired functional performances is highly sought after. The following paper aims to detail how a modified coaxial electrospraying has been developed to create ibuprofen-loaded hydroxypropyl methylcellulose nanoparticles for improving the drug dissolution rate. During the working processes, a key parameter, i.e., the spreading angle of atomization region (θ, °), could provide a linkage among the working process, the property of generated nanoparticles and their functional performance. Compared with the applied voltage (V, kV; D = 2713 − 82V with RθV2 = 0.9623), θ could provide a better correlation with the diameter of resultant nanoparticles (D, nm; D = 1096 − 5θ with RDθ2 = 0.9905), suggesting a usefulness of accurately predicting the nanoparticle diameter. The drug released from the electrosprayed nanoparticles involved both erosion and diffusion mechanisms. A univariate quadratic equation between the time of releasing 95% of the loaded drug (t, min) and D (t = 38.7 + 0.097D − 4.838 × 105D2 with a R2 value of 0.9976) suggests that the nanoparticle diameter has a profound influence on the drug release performance. The clear process-property-performance relationship should be useful for optimizing the electrospraying process, and in turn for achieving the desired medicated nanoparticles.

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“…The concept relies on preparing drug-loaded niosomes with pH-sensitive molecules added to the formulation; the niosomes are stable under physiological conditions but undergo structural changes when exposed to pathological conditions [ 81 , 82 ]. These niosomes comprise non-ionic surfactants and cholesterol as basic components; pH sensitivity is achieved through adding molecules such as peptides [ 83 ], derivatized lipids [ 84 , 85 ], derivatized surfactants [ 86 ] and pH-sensitive polymers [ 87 , 88 ].…”

Section: Specialised Niosomesmentioning

confidence: 99%

Current Advances in Specialised Niosomal Drug Delivery: Manufacture, Characterization and Drug Delivery Applications

Witika

Bassey

Demana

et al. 2022

IJMS

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Development of nanomaterials for drug delivery has received considerable attention due to their potential for achieving on-target delivery to the diseased area while the surrounding healthy tissue is spared. Safe and efficiently delivered payloads have always been a challenge in pharmaceutics. Niosomes are self-assembled vesicular nanocarriers formed by hydration of a non-ionic surfactant, cholesterol or other molecules that combine to form a versatile drug delivery system with a variety of applications ranging from topical delivery to targeted delivery. Niosomes have advantages similar to those of liposomes with regards to their ability to incorporate both hydrophilic and hydrophobic payloads. Moreover, niosomes have simple manufacturing methods, low production cost and exhibit extended stability, consequently overcoming the major drawbacks associated with liposomes. This review provides a comprehensive summary of niosomal research to date, including the types of niosomes and critical material attributes (CMA) and critical process parameters (CPP) of niosomes and their effects on the critical quality attributes (CQA) of the technology. Furthermore, physical characterisation techniques of niosomes are provided. The review then highlights recent applications of specialised niosomes in drug delivery. Finally, limitations and prospects for this technology are discussed.

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Long-Lasting, Antinociceptive Effects of pH-Sensitive Niosomes Loaded with Ibuprofen in Acute and Chronic Models of Pain

Cited by 17 publications

References 40 publications

Innovative topical niosomal gel formulation containing diclofenac sodium (niofenac)

Innovative topical niosomal gel formulation containing diclofenac sodium (niofenac)

The Process–Property–Performance Relationship of Medicated Nanoparticles Prepared by Modified Coaxial Electrospraying

Current Advances in Specialised Niosomal Drug Delivery: Manufacture, Characterization and Drug Delivery Applications

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