Long COVID in the context of social determinants of health

Lukkahatai, Nada; Rodney, Tamar; Ling, Catherine; Daniel, Brittany; Han, Hae Ra

doi:10.3389/fpubh.2023.1098443

Cited by 11 publications

(6 citation statements)

References 85 publications

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“…The WHO defines socioeconomic and political context and socioeconomic position as the structural determinants and material circumstances, behaviors and biological factors, and psychosocial factors as intermediary determinants. The inter and inter relationship among all these factors and determinants will provide time to resolution of symptoms, health care utilization, quality of life (these three variables as a collection considered to be the ‘health outcomes’) [ 36 ]. During the post-COVID-19 period, the number of television viewers and the percentage of activity on social networks are expected to increase significantly [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Social determinants of health during and after coronavirus: a qualitative study

sabet,

Aminbeidokhti,

Jafari

2024

BMC Public Health

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Background Health has multiple dimensions influenced not only by individual factors but also by broader social, economic, cultural, and political structures. The widespread COVID-19 pandemic has multidimensional effects on people’s lives, which can have effects on individuals’ lifestyles after the COVID-19. This study aimed to speculate the social determinants of health during and after the COVID-19, which can lead to more effective planning for promoting community health. Methods The present study interviewed 21 experts in social and medical fields during four months. The sampling method was snowball. The interviews were semi-structured and administered in-person or electronic. All interviews were transcribed and analyzed according to the Brown and Clarke’s six-stage framework to extract themes. Results the participants were 13 males, eight experts in social field, all had PhD, 17 were academic members, and 10 were members of the Social Determinants of Health Research Center. The qualitative content analysis induced seven different social themes that affect the health which included: justice (3 Subcategories), integration (4 Subcategories), acceptance (4 Subcategories), participation (2 Subcategories), adaptation (3 Subcategories), flourishing (4 Subcategories), and cohesion (3 Subcategories). Conclusions According to the present study, a grand plan to cover all positive and negative social effects of COVID-19 should have at least seven different dimensions. However, the present models of effective social determinants in health do not have such comprehensiveness. Future studies may provide a proper model to be used in clinical and research fields.

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Section: Discussionmentioning

confidence: 99%

Social determinants of health during and after coronavirus: a qualitative study

sabet,

Aminbeidokhti,

Jafari

2024

BMC Public Health

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“…In this context, firstly, cardiopulmonary symptoms, such as shortness of breath or intermittent chest pain presumably based on abnormalities related to myocardial inflammation, remodeling, and arrhythmias, and secondly, disturbed autonomic and neuropsychiatric manifestations, such as fatigue, headaches, brain fog, or orthostatic disorders, are previously known manifestations [14,35]. Additionally, some LCS patients are disproportionately affected by their social determinants of health (SDOH), due to socioeconomic and political factors as well as behavior and psychosocial background [36]. Up to now, the pathophysiological background of the persistent cardiophysiological and pulmonary abnormalities remains unclear to a certain degree with significant dissociation between symptoms and objective parameters [14].…”

Section: Covid-19 and Lcsmentioning

confidence: 99%

SGLT2 Inhibitors in Long COVID Syndrome: Is There a Potential Role?

Zimmermann,

Sourij,

Aberer

et al. 2023

JCDD

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The coronavirus disease (COVID)-19 has turned into a pandemic causing a global public health crisis. While acute COVID-19 mainly affects the respiratory system and can cause acute respiratory distress syndrome, an association with persistent inflammatory stress affecting different organ systems has been elucidated in long COVID syndrome (LCS). Increased severity and mortality rates have been reported due to cardiophysiological and metabolic systemic disorders as well as multiorgan failure in COVID-19, additionally accompanied by chronic dyspnea and fatigue in LCS. Hence, novel therapies have been tested to improve the outcomes of LCS of which one potential candidate might be sodium–glucose cotransporter 2 (SGLT2) inhibitors. The aim of this narrative review was to discuss rationales for investigating SGLT2 inhibitor therapy in people suffering from LCS. In this regard, we discuss their potential positive effects—next to the well described “cardio-renal-metabolic” conditions—with a focus on potential anti-inflammatory and beneficial systemic effects in LCS. However, potential beneficial as well as potential disadvantageous effects of SGLT2 inhibitors on the prevalence and long-term outcomes of COVID-19 will need to be established in ongoing research.

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“…The etiology of PASC, and therefore PPASC, is not yet known, but ongoing studies have provided risk factors and potential predictors of PASC development. Factors, such as female sex, age, comorbidities, smoking, and social determinants of health (low socioeconomic status and racial/ethnic minority) are associated with an increased risk of PASC development (22)(23)(24). While the severity of COVID-19 is suspected to be a risk factor for PASC (25), evidence continues to present mixed conclusions (26)(27)(28)(29)(30)(31)(32).…”

Section: Introductionmentioning

confidence: 99%

Single‐cell RNA sequencing reveals characteristics of myeloid cells in post-acute sequelae of SARS-CoV-2 patients with persistent respiratory symptoms

Yoon,

Dean,

Jiyarom

et al. 2024

Front. Immunol.

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BackgroundAlthough our understanding of the immunopathology and subsequent risk and severity of COVID-19 disease is evolving, a detailed account of immune responses that contribute to the long-term consequences of pulmonary complications in COVID-19 infection remains unclear. Few studies have detailed the immune and cytokine profiles associated with post-acute sequelae of SARS-CoV-2 infection (PASC) with persistent pulmonary symptoms. The dysregulation of the immune system that drives pulmonary sequelae in COVID-19 survivors and PASC sufferers remains largely unknown.ResultsTo characterize the immunological features of pulmonary PASC (PPASC), we performed droplet-based single-cell RNA sequencing (scRNA-seq) to study the transcriptomic profiles of peripheral blood mononuclear cells (PBMCs) from a participant naïve to SARS-CoV-2 (Control) (n=1) and infected with SARS-CoV-2 with chronic pulmonary symptoms (PPASC) (n=2). After integrating scRNA-seq data with a naïve participant from a published dataset, 11 distinct cell populations were identified based on the expression of canonical markers. The proportion of myeloid-lineage cells ([MLCs]; CD14+/CD16+monocytes, and dendritic cells) was increased in PPASC (n=2) compared to controls (n=2). MLCs from PPASC displayed up-regulation of genes associated with pulmonary symptoms/fibrosis, while glycolysis metabolism-related genes were downregulated. Similarly, pathway analysis showed that fibrosis-related (VEGF, WNT, and SMAD) and cell death pathways were up-regulated, but immune pathways were down-regulated in PPASC. Further comparison of PPASC with scRNA-seq data with Severe COVID-19 (n=4) data demonstrated enrichment of fibrotic transcriptional signatures. In PPASC, we observed interactive VEGF ligand-receptor pairs among MLCs, and network modules in CD14+ (cluster 4) and CD16+ (Cluster 5) monocytes displayed a significant enrichment for biological pathways linked to adverse COVID-19 outcomes, fibrosis, and angiogenesis. Further analysis revealed a distinct metabolic alteration in MLCs with a down-regulation of glycolysis/gluconeogenesis in PPASC compared to SARS-CoV-2 naïve samples.ConclusionAnalysis of a small scRNA-seq dataset demonstrated alterations in the immune response and cellular landscape in PPASC. The presence of elevated MLC levels and their corresponding gene signatures associated with fibrosis, immune response suppression, and altered metabolic states suggests a potential role in PPASC development.

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Long COVID in the context of social determinants of health

Cited by 11 publications

References 85 publications

Social determinants of health during and after coronavirus: a qualitative study

Social determinants of health during and after coronavirus: a qualitative study

SGLT2 Inhibitors in Long COVID Syndrome: Is There a Potential Role?

Single‐cell RNA sequencing reveals characteristics of myeloid cells in post-acute sequelae of SARS-CoV-2 patients with persistent respiratory symptoms

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