Long covid clinics should be run as research hubs

McCartney, Margaret; Byng, Richard

doi:10.1136/bmj.n1996

Cited by 6 publications

(6 citation statements)

References 12 publications

(15 reference statements)

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“…It thus deserves a separate and more focused discussion, and needs an integrated multidisciplinary management tailored explicitly to the type and severity of symptoms. 47 To date, rehabilitation seems the most effective treatment, but the progress of the ongoing research will help to uncover the numerous multifaceted pathogenic mechanisms sustaining the persistence of symptoms over (long) time, and thus will enable us to identify a therapeutic strategy that could be tailored to individual care needs. 48 The final aspect deserving specific comment is the future risk that the reverse -transcribed SARS--CoV -2 RNA could be integrated within the genome of infected human cells, where it could persist stably, influencing gene expression but also being actively re -expressed after months or years, the consequences of which are as yet completely unpredictable.…”

Section: Impact Of Covid -19 Vaccinationmentioning

confidence: 99%

COVID-19 and its long-term sequelae: what do we know in 2023?

Lippi¹,

Sanchís-Gomar²,

Henry³

2023

Polish Archives of Internal Medicine

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vaccine -elicited, or both) or the virus attenuation, 3 the overall number of deaths and the mortality rate are also substantially underestimated. According to recent epidemiologic evidence from the WHO, the global number of COVID -19-related deaths may be up to 3 -fold higher than officially reported, 4 with ample variations in the volume of excess deaths worldwide (eg, the underestimation bias may even exceed 50% in certain South American regions). Likewise, a debate is fueling over the fact that the way COVID -19-related deaths are counted in some countries may not reflect the real scenario, with several million deaths missed by official statistics. 5 That said, and with the apparent preamble that pandemic numbers are largely biased and will continue to grow in the foreseeable future (COVID -19 seems now Current epidemiology of COVID -19 COVID -19 is a life -threatening infectious disease sustained by SARS -CoV -2, the virus first identified in the Chinese town of Wuhan in November 2019. Thereafter, it has spread rapidly worldwide, and the World Health Organization (WHO) has finally classified it as a pandemic disease in March 2020. 1 The accurate characterization of the ongoing COVID -19 epidemic is challenging for countless reasons. First, the number of official cases of SARS -CoV -2 infection is underestimated mainly because of under testing and under -reporting all around the world, making it impossible to provide accurate measures of its current frequency. 2 Then, although it is undeniable that the clinical severity of COVID -19 has considerably declined over time due to either immunity (natural,

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Section: Impact Of Covid -19 Vaccinationmentioning

confidence: 99%

COVID-19 and its long-term sequelae: what do we know in 2023?

Lippi¹,

Sanchís-Gomar²,

Henry³

2023

Polish Archives of Internal Medicine

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“…There were fewer CLoCk Delphi participants from the least deprived areas of England than in the main sample (16.45% and 20.4%, respectively). No problems Some problems A lot of problems There was no difference between the two groups in emotional well-being as assessed by total SDQ scores (median 12 (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17) for PCS young people and 11 (6)(7)(8)(9)(10)(11)(12)(13)(14)(15) for young people in CLoCk (z = −1.8; p = 0.07)). However, SDQ impact scores were significantly higher in PCS young people (PCS: 2 (0-5); CLoCk 0 (0-1); z = −7.7; p < 0.001) indicating symptoms were having a greater impairment and causing more distress.…”

Section: Subgroup Analysis-pcs and Clock Delphi Young Peoplementioning

confidence: 94%

Children and Young People with Long COVID—Comparing Those Seen in Post-COVID Services with a Non-Hospitalised National Cohort: A Descriptive Study

Newlands,

Goddings,

Juste

et al. 2023

Children

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Background: Post-COVID services have been set up in England to treat children with ongoing symptoms of Long COVID. To date, the characteristics of children seeking treatment from these services has not been described. Purpose: (1) to describe the characteristics of children aged 11–17 referred to the Pan-London Post-COVID service and (2) to compare characteristics of these children with those taking part in the United Kingdom’s largest research study of Long COVID in children (CLoCk). Design: Data from 95 children seeking treatment from the Post-COVID service between May 2021 and August 2022 were included in the study. Their demographic characteristics, symptom burden and the impact of infection are described and compared to children from CLoCk. Results: A high proportion of children from the Post-COVID service and CLoCk reported experiencing health problems prior to the pandemic. Almost all Post-COVID service children met the research Delphi definition of Long COVID (94.6%), having multiple symptoms that impacted their lives. Symptoms were notably more severe than the participants in CLoCk. Conclusions: This study describes the characteristics of children seeking treatment for Long COVID compared to those identified in the largest longitudinal observational study to date. Post-COVID service children have more symptoms and are more severely affected by their symptoms following infection with COVID-19 than children in the CLoCk study. Research to understand predisposing factors for severity and prognostic indicators is essential to prevent this debilitating condition. Evaluation of short- and long-term outcomes of interventions by clinical services can help direct future therapy for this group.

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“…Special clinics are being developed to diagnose and treat both children and adults with long COVID‐19 and such clinics will provide essential long‐term data regarding prognosis, neurological and beyond. 107 , 108 , 109 …”

Section: Role Of the Brain Developmental Stagementioning

confidence: 99%

“…Special clinics are being developed to diagnose and treat both children and adults with long COVID-19 and such clinics will provide essential long-term data regarding prognosis, neurological and beyond. [107][108][109] Some of the lingering post-COVID-19 symptoms may be related to consequences of the infection itself, to altered immune function, or to other biological factors. It is also possible that some children reporting those symptoms have suffered the manifold psychological stressors of the pandemic itself and that their symptoms may not directly relate to the biological aspects of the disease.…”

Section: Long Covid-19mentioning

confidence: 99%

“…Addressing these long‐term sequelae is critical for quality of life in patients who have survived acute COVID‐19 and will require allocation of appropriate resources and services. Special clinics are being developed to diagnose and treat both children and adults with long COVID‐19 and such clinics will provide essential long‐term data regarding prognosis, neurological and beyond 107–109 …”

Section: Role Of the Brain Developmental Stagementioning

confidence: 99%

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Neurological effects of COVID‐19 in infants and children

Stafstrom

2022

Develop Med Child Neuro

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Neurological manifestations of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in children are becoming increasingly apparent as the coronavirus disease (COVID‐19) pandemic continues. While children manifest relatively milder features of the disease, accumulating evidence warrants concern that COVID‐19 exacts both acute‐ and long‐term effects on the developing central and peripheral nervous systems. This review focuses on the relatively underinvestigated topic of the effects of SARS‐CoV‐2 on the brain in infancy and childhood, concluding that clinicians should be attentive to both the acute effects and long‐term consequences of COVID‐19 from a neurological perspective.

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Long covid clinics should be run as research hubs

Cited by 6 publications

References 12 publications

COVID-19 and its long-term sequelae: what do we know in 2023?

COVID-19 and its long-term sequelae: what do we know in 2023?

Children and Young People with Long COVID—Comparing Those Seen in Post-COVID Services with a Non-Hospitalised National Cohort: A Descriptive Study

Neurological effects of COVID‐19 in infants and children

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