Long-chain triglycerides improve recovery from myocardial stunning in conscious dogs

Velde, Marc Van de; Wouters, Patrick; Rolf, Norbert; Aken, Hugo Van; Flameng, Willem; Vandermeersch, Eugéne

doi:10.1016/s0008-6363(96)00165-4

Cited by 82 publications

(48 citation statements)

References 29 publications

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“…It has been demonstrated that administration of triglycerides during reperfusion significantly improves myocardial contractility in a canine I/R injury model [27], suggesting that lipid treatment can improve cardiac function. Our hemodynamic data showed that compared with the sham group, the three I/R-treated groups had reductions of all hemodynamic parameters, demonstrating that I/R injury induced damage to cardiac function.…”

Section: Discussionmentioning

confidence: 99%

ω-3 Polyunsaturated Fatty Acid Postconditioning Protects the Isolated Perfused Rat Heart from Ischemia-Reperfusion Injury

et al. 2018

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Aims: This study aimed to evaluate the cardioprotective effects of ω-3 polyunsaturated fatty acids (PUFAs) postconditioning against ischemia-reperfusion (I/R) injury. Methods: Sixty Sprague-Dawley rats were randomly divided into 4 groups (n = 15 for each) and used to generate the Langendorff isolated perfused rat heart model. The sham group received a continuous perfusion of 150 min. The remaining three I/R-treated groups sequentially received a 30-min perfusion, a 30-min cardioplegia, and a 90-min reperfusion. The I/R-ischemic preconditioning (IP) group additionally received three cycles of 20-s reperfusion and 20-s coronary reocclusion preceded the 90 min of reperfusion. The I/R-ω group were perfused with ω-3 PUFAs for 15 min before the 90 min of reperfusion. The myocardial infarct size, the degree of mitochondrial damage, the antioxidant capacity of the myocardium, and the cardiac functions during reperfusion were compared among groups. Results: Compared with the I/R group, the I/R-ω group had significantly reduced myocardial infarct size, reduced levels of lactate dehydrogenase and malondialdehyde, elevated superoxide dismutase level, and elevated rising (+dp/dt_max) and descending (–dp/dt_max) rate of left ventricular pressure. The I/R-ω group had a significantly lower rate of mitochondrial damage in myocardial tissue compared with the I/R and I/R-IP groups. Conclusion: ω-3 PUFA postconditioning possesses good cardioprotective effects and may be developed into a therapeutic strategy for myocardial I/R injury.

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Section: Discussionmentioning

confidence: 99%

ω-3 Polyunsaturated Fatty Acid Postconditioning Protects the Isolated Perfused Rat Heart from Ischemia-Reperfusion Injury

et al. 2018

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“…Baclofen is a relatively weakly lipophilic drug, therefore, a comparatively large dose of ILE may be required to produce a clinical response. It has also been suggested that ILE therapy may be linked to improvements in cardiac function in cases of local anaesthetic toxicoses via a direct effect on the myocardium due to improved fatty acid oxidation (Van de Velde and others 1996). …”

Section: Discussionmentioning

confidence: 99%

Treatment of a case of feline baclofen toxicosis with intravenous lipid therapy

Edwards¹,

Shihab²,

Scott³

2014

Vet Record Case Reports

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Baclofen (γ-amino-β-[p-chlorophenyl]-butyric acid) is a centrally acting skeletal muscle relaxant that is frequently used in people. Baclofen toxicosis has previously been successfully treated in cats via supportive therapy alone, whereas administration of an intravenous lipid emulsion (ILE) has been reported as an adjunct to supportive therapy in dogs with baclofen toxicosis. This case report presents a cat that became severely stuporous following ingestion of baclofen (10 mg/kg) and was successfully treated with administration of ILE without any apparent side effects. The cat received a 1.5 ml/kg bolus of a 20 per cent lipid emulsion intravenously followed by a constant rate infusion (CRI) of 15 ml/kg/hour. Approximately one hour following initiation of the CRI, the cat became acutely more responsive. Intravenous lipid therapy may be a useful adjunct to conventional treatment in cases of feline baclofen toxicosis and other lipophilic drug toxicoses.

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“…A second speculated mechanism is that ILE may increase myocardial calcium levels leading to improved contractility [20,21]. A third possibility is that ILE may improve myocardial ATP synthesis by increasing the amount of available fatty acid substrate [22,23]. A fourth possibility is that some combination of these factors is involved and the beneficial effect of ILE depends upon which effect predominates in a particular scenario.…”

Section: Discussionmentioning

confidence: 99%

Intravenous Lipid Emulsion Alters the Hemodynamic Response to Epinephrine in a Rat Model

et al. 2013

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Intravenous lipid emulsion (ILE) is an adjunctive antidote used in selected critically ill poisoned patients. These patients may also require administration of advanced cardiac life support (ACLS) drugs. Limited data is available to describe interactions of ILE with standard ACLS drugs, specifically epinephrine. Twenty rats with intra-arterial and intravenous access were sedated with isoflurane and split into ILE or normal saline (NS) pretreatment groups. All received epinephrine 15 μm/kg intravenously (IV). Continuous mean arterial pressure (MAP) and heart rate (HR) were monitored until both indices returned to baseline. Standardized t tests were used to compare peak MAP, time to peak MAP, maximum change in HR, time to maximum change in HR, and time to return to baseline MAP/HR. There was a significant difference (p=0.023) in time to peak MAP in the ILE group (54 s, 95 % CI 44-64) versus the NS group (40 s, 95 % CI 32-48) and a significant difference (p=0.004) in time to return to baseline MAP in ILE group (171 s, 95 % CI 148-194) versus NS group (130 s, 95 % CI 113-147). There were no significant differences in the peak change in MAP, peak change in HR, time to minimum HR, or time to return to baseline HR between groups. ILE-pretreated rats had a significant difference in MAP response to epinephrine; ILE delayed the peak effect and prolonged the duration of effect of epinephrine on MAP, but did not alter the peak increase in MAP or the HR response.

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Long-chain triglycerides improve recovery from myocardial stunning in conscious dogs

Cited by 82 publications

References 29 publications

ω-3 Polyunsaturated Fatty Acid Postconditioning Protects the Isolated Perfused Rat Heart from Ischemia-Reperfusion Injury

ω-3 Polyunsaturated Fatty Acid Postconditioning Protects the Isolated Perfused Rat Heart from Ischemia-Reperfusion Injury

Treatment of a case of feline baclofen toxicosis with intravenous lipid therapy

Intravenous Lipid Emulsion Alters the Hemodynamic Response to Epinephrine in a Rat Model

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