Long-chain polyunsaturated fatty acids protect the heart against ischemia/reperfusion-induced injury via a MAPK dependent pathway

Engelbrecht, Anna‐Mart; Engelbrecht, P; Genade, Sonia; Niesler, Carola U.; Page, Carine; Smuts, Cornelius M.; Lochner, Amanda

doi:10.1016/j.yjmcc.2005.08.004

Cited by 36 publications

(25 citation statements)

References 62 publications

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“…The suppression of P38 phosphorylation may contribute to the effects of PUFA in ischemia-reperfusion models. 24,25 MAP kinases play important roles in cardiac remodeling, with P38 kinase appearing to be particularly important in producing tissue fibrosis. 26 There is evidence for an important role of MAP kinases in AF patients.…”

Section: Potential Mechanisms Of Structural Remodeling Prevention By mentioning

confidence: 99%

Omega-3 Polyunsaturated Fatty Acids Prevent Atrial Fibrillation Associated With Heart Failure but Not Atrial Tachycardia Remodeling

et al. 2007

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Background-There is epidemiological evidence that omega-3 polyunsaturated fatty acids (PUFAs) reduce the risk of atrial fibrillation (AF), but clinical data are conflicting. The present study assessed the effects of PUFA on AF in experimental models. Methods and Results-We studied the effects of oral PUFA supplements in 2 experimental AF paradigms: electrical remodeling induced by atrial tachypacing (400 bpm for 1 week) and congestive heart failure-associated structural remodeling induced by ventricular tachypacing (240 bpm for 2 weeks). PUFA pretreatment did not directly change atrial effective refractory period (128Ϯ6 [meanϮSEM] versus 127Ϯ2 ms; all effective refractory periods at 300-ms cycle lengths) or burst pacing-induced AF duration (5Ϯ4 versus 34Ϯ18 seconds). Atrial tachypacing dogs had shorter refractory periods (73Ϯ6 ms) and greater AF duration (1185Ϯ300 seconds) than shams (119Ϯ5 ms and 20Ϯ11 seconds; PϽ0.01 for each). PUFAs did not significantly alter atrial tachypacing effects on refractory periods (77Ϯ8 ms) or AF duration (1128Ϯ412 seconds). PUFAs suppressed ventricular tachypacing-induced increases in AF duration (952Ϯ221 versus 318Ϯ249 seconds; PϽ0.05) and attenuated congestive heart failure-related atrial fibrosis (from 19.2Ϯ1.1% to 5.8Ϯ1.0%; PϽ0.001) and conduction abnormalities. PUFAs also attenuated ventricular tachypacing-induced hemodynamic dysfunction (eg, left ventricular end-diastolic and left atrial pressure from 12.2Ϯ0.5 and 11.4Ϯ0.6 mm Hg, respectively, to 6.4Ϯ0.5 and 7.0Ϯ0.8 mm Hg; PϽ0.01) and phosphorylation of mitogen-activated protein kinases (extracellular-signal related and P38 kinase). Conclusions-PUFAs

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Section: Potential Mechanisms Of Structural Remodeling Prevention By mentioning

confidence: 99%

Omega-3 Polyunsaturated Fatty Acids Prevent Atrial Fibrillation Associated With Heart Failure but Not Atrial Tachycardia Remodeling

et al. 2007

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“…These were associated with associated with upregulation of MKP-1 protein expression [94]. Furthermore, it was also shown by us that upregulation of MKP-1 during simulated ischemia/reperfusion is associated with an attenuation of apoptosis in neonatal cardiomyocytes [93].…”

Section: Map Kinase Phosphatase-1 (Mkp-1): a Mediator Of The Beneficimentioning

confidence: 57%

“…The inhibition of p38-MAPK was then shown to be mediated by MKP-1. We and others have also demonstrated that dexamethasone induces the expression of MKP-1 which potently inactivated p38-MAPK [93][94]. Wu and Bennet (2005) demonstrated that MKP-1 promotes cell survival in fibroblasts through the attenuation of stress responsive MAPK-mediated apoptosis [95].…”

Section: Map Kinase Phosphatase-1 (Mkp-1): a Mediator Of The Beneficimentioning

confidence: 74%

“…It has been suggested that upregulation of MKP-1 during ischemia/reperfusion-induced stress attenuates myocardial injury [93,94]. MKP-1, found predominantly in the nucleus, is a dual specific phosphatase which dephosphorylates phosphotyrosine and phosphothreonine-containing protein kinases such as the MAPKs.…”

Section: Discussionmentioning

confidence: 99%

“…Wu and Bennet (2005) demonstrated that MKP-1 promotes cell survival in fibroblasts through the attenuation of stress responsive MAPK-mediated apoptosis [95]. Upregulation of MKP-1 has also been shown to be associated with cardioprotection by long-chain polyunsaturated fatty acids [93]. It has also been reported that transgenic mice overexpressing MKP-1 were protected, whereas knock-out mice show greater injury after ischemia/reperfusion [96].…”

Section: Map Kinase Phosphatase-1 (Mkp-1): a Mediator Of The Beneficimentioning

confidence: 99%

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Long-chain polyunsaturated fatty acids protect the heart against ischemia/reperfusion-induced injury via a MAPK dependent pathway

Cited by 36 publications

References 62 publications

Omega-3 Polyunsaturated Fatty Acids Prevent Atrial Fibrillation Associated With Heart Failure but Not Atrial Tachycardia Remodeling

Omega-3 Polyunsaturated Fatty Acids Prevent Atrial Fibrillation Associated With Heart Failure but Not Atrial Tachycardia Remodeling

Glucocorticoid-Induced Cardioprotection: A Novel Role for Autophagy

Molecular Mechanisms behind the Beneficial Activity of Polyunsaturated Fatty Acids in Alzheimer's Disease and Related Conditions

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