Long chain polyunsaturated fatty acids in mothers and term babies

Kilari, Anitha; Mehendale, Savita; Dangat, Kamini; Yadav, Hemlata R.; Kulakarni, Asmita V.; Dhobale, Madhavi; Taralekar, Vaishali; Joshi, Sadhana

doi:10.1515/jpm.2009.096

Cited by 40 publications

(21 citation statements)

References 30 publications

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“…It is reported that the levels of dietary n 2 3 fatty acids in India are low (Ghafoorunissa, 1996). Our earlier studies have also shown that mothers delivering preterm LBW babies have lower plasma and erythrocyte docosahexaenoic acid levels (Kilari et al, 2010) when compared with term deliveries (Kilari et al, 2009). We have also shown lower levels of docosahexaenoic acid in pre-eclamptic women delivering at term, compared to healthy pregnant women (Mehendale et al, 2008).…”

supporting

confidence: 55%

“…The women (n 5 253) with singleton pregnancies delivered at term (37 weeks gestation) without any pregnancy complications were recruited during the year 2007-2009. Statistical power was calculated using plasma DHA values from our earlier studies in term and preterm women (Kilari et al, 2009(Kilari et al, , 2010, where we have reported significant group differences in DHA concentrations in plasma from 63 preterm and 148 women delivering at term (P < 0.05). Thus, with such an effect size, we proposed the sample size of 150 women delivering babies with NBW 60 women with LBW.…”

Section: Methodsmentioning

confidence: 99%

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Associations of long‐chain polyunsaturated fatty acid concentrations with birth outcome in term Indian mothers and their neonates

Kilari¹,

Mehendale²,

Dangat³

et al. 2010

American J Hum Biol

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The purpose of this study was to examine the maternal and cord long-chain polyunsaturated fatty acid (LCPUFA) concentrations and their associations with birth outcome in term deliveries. Pregnant women (n = 253) delivering at term were divided into two groups based on their babies' birth weights (1) normal birth weight (NBW), that is, ≥2.5 kg (n = 190) and (2) low-birth weight (LBW), that is, <2.5 kg (n = 63). Each group is further divided into two groups according to the baby's sex, that is, male NBW (M-NBW), female NBW (F-NBW), male LBW (M-LBW), and female LBW (F-LBW) groups. Maternal plasma docosahexaenoic acid and erythrocyte arachidonic acid (AA) levels were lower (P < 0.05 for both), while cord plasma docosahexaenoic acid and erythrocyte AA levels were higher (P < 0.05 for both) in LBW group when compared to the NBW group. Maternal erythrocyte AA levels were positively associated with birth weight (P = 0.001), while cord plasma docosahexaenoic acid levels were negatively (P = 0.05) associated with birth weight. Reduced maternal and increased cord LCPUFA levels exist in mothers delivering LBW babies, especially in mothers delivering female babies, indicative of sex-specific effects.

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supporting

confidence: 55%

Section: Methodsmentioning

confidence: 99%

Associations of long‐chain polyunsaturated fatty acid concentrations with birth outcome in term Indian mothers and their neonates

Kilari¹,

Mehendale²,

Dangat³

et al. 2010

American J Hum Biol

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“…All participants had limited access to foods fortified with folic acid and vitamin B 12 . The food frequency questionnaire has been used by us in a number of studies on pregnant women [9,23,24]. …”

Section: Methodsmentioning

confidence: 99%

Reduced Folate, Increased Vitamin B<sub>12</sub> and Homocysteine Concentrations in Women Delivering Preterm

et al. 2012

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Background and Aim: Maternal nutrition is an important determinant of the duration of pregnancy and fetal growth, and thereby influences pregnancy outcome. Folic acid and vitamin B₁₂ are involved in one-carbon metabolism and are reported to underlie intrauterine programming of adult diseases. Methods: In the present study, the levels of folate, vitamin B₁₂ and homocysteine were measured in mothers delivering preterm (PT; gestation <37 weeks; n = 67), those delivering preterm due to preeclampsia (PT-PE; n = 49) and women delivering at term (control group; n = 76). Results: Increased vitamin B₁₂ and homocysteine levels (p < 0.05 for both) were seen in the PT-PE and PT groups as compared to the controls. In addition, reduced folate levels (p < 0.05) were observed in the PT group. A negative association of maternal plasma homocysteine with birth weight was seen in the idiopathic preterm group. Conclusions: Altered maternal micronutrients and resultant increased homocysteine concentrations exist in women delivering preterm. These alterations may also be partly associated with other factors such as undiagnosed inflammatory conditions or inadequate placentation in some women. Since these micronutrients play an important role in epigenetic regulation of vital genes involved in the fetal programming of adult diseases, further studies need to be undertaken to understand their role in preterm deliveries.

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“…26,29,30 Briefly, transesterification of the phospholipid fraction was performed using hydrochloric acid-methanol. Methyl esters were separated using a Perkin Elmer gas chromatograph (SP 2330, 30 m capillary Supelco column, Perkin Elmer, Shelton, CT, USA).…”

Section: Fatty Acid Estimation From Maternal and Cord Plasmamentioning

confidence: 99%

Circulating angiogenic factors and their association with birth outcomes in preeclampsia

et al. 2010

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This study was designed to test the hypothesis that altered angiogenic factors together with increased oxidative stress and reduced docosahexaenoic acid (DHA) levels may be associated with altered birth outcome parameters. To test this hypothesis, levels of plasma vascular endothelial growth factor (VEGF), placental growth factor (PlGF), soluble fms-like tyrosine kinase-1 (sFlt-1), the oxidative stress marker malondialdehyde (MDA) and fatty acids were estimated in women with preeclampsia and their cord samples and compared with those in normotensive women. The association of these parameters with birth outcome was also examined. Our results show that in preeclamptic women, maternal plasma VEGF and PlGF levels were lower, whereas sFlt-1 levels were higher (Po0.05 for all) than in normotensive women. In contrast, cord plasma VEGF levels were higher (Po0.05) in preeclamptic women, whereas there was no difference in sFlt-1 levels. Plasma DHA levels in both the mother and cord were lower (Po0.05) in the preeclamptic group compared with normotensive women. Maternal plasma sFlt-1 levels were positively (n¼23, r¼0.415, P¼0.039) associated with MDA concentrations in preeclamptic women. Maternal plasma sFlt-1 levels showed a strong negative association with baby weight (n¼37, r¼À0.547, P¼0.001), head circumference (n¼37, r¼À0.472, P¼0.005) and baby chest circumference (n¼37, r¼À0.375, P¼0.032) in the preeclamptic group. Cord plasma sFlt-1 concentrations were negatively associated with cord plasma DHA concentrations (n¼28, r¼À0.552, P¼0.004). This study suggests that dysregulation of angiogenic factors may be associated with maternal oxidative stress. Increased oxidative stress may reduce cord DHA levels and increase sFlt-1 levels, leading to poor birth outcomes in preeclampsia.

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Long chain polyunsaturated fatty acids in mothers and term babies

Cited by 40 publications

References 30 publications

Associations of long‐chain polyunsaturated fatty acid concentrations with birth outcome in term Indian mothers and their neonates

Associations of long‐chain polyunsaturated fatty acid concentrations with birth outcome in term Indian mothers and their neonates

Reduced Folate, Increased Vitamin B<sub>12</sub> and Homocysteine Concentrations in Women Delivering Preterm

Circulating angiogenic factors and their association with birth outcomes in preeclampsia

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