Long chain polyunsaturate supplementation does not induce excess lipid peroxidation of piglet tissues

Sarkadi-Nagy, Eszter; Huang, Meng‐Chuan; Diau, Guan-Yeu; Kirwan, Ryan C; Chao, Angela Chueh; Tschanz, Carolyn L.; Brenna, J. Thomas

doi:10.1007/s00394-003-0422-6

Cited by 20 publications

(11 citation statements)

References 15 publications

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“…(2008) recently concluded that TBARS measured in plasma increased in a dose‐responsive manner when fish oil was supplemented for 12 weeks to laying hens. In contrast with these latter study results, Sarkadi‐Nagy et al. (2003) reported that there is no influence of the amount of DHA present in the diet of piglets.…”

Section: Discussioncontrasting

confidence: 79%

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Dose-response effect of fish oil substitution in parturition feed on erythrocyte membrane characteristics and sow performance

Cools

Maes

Papadopoulos

et al. 2010

Journal of Animal Physiology and Animal Nutrition

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The present study aimed to investigate whether n-3 polyunsaturated fatty acids (PUFA) incorporate into erythrocyte membranes of peripartal sows in a dose-responsive manner and whether the altered fatty acid profile affects the cell membrane characteristics. At day 109 of gestation (day 0), 51 sows were divided into five treatment groups. Each group received a diet with a different ratio of fish oil to pork lard for nine consecutive days. Blood samples were taken at day 0 and 10 days later. The fatty acid profile of erythrocytes was determined, as well as the osmotic fragility and oxidative stability of erythrocytes. Thiobarbituric acid reactive substances (TBARS) and ferric reducing ability of plasma (FRAP) were determined in plasma samples. Finally, reproductive and performance parameters of both sows and piglets were recorded until weaning. Supplementation of fish oil during the peripartal period changed the fatty acid profile of erythrocyte membranes in a dose-responsive manner. Although the n-3 PUFA content of erythrocyte membranes increased with increasing amounts of fish oil in the diet, no significant effect on erythrocyte osmotic fragility could be recorded. In contrast, oxidative stability of erythrocytes decreased linearly with increasing amounts of fish oil in the diet. Similarly, both TBARS and FRAP linearly increased with increasing percentages of fish oil in the diet. Neither piglet nor sow performance was influenced by dietary treatments, except for a decrease of both piglet survival and weaning weight with increasing quantities of fish oil supplemented. It is concluded that changes in dietary lipid sources can affect the membrane's fatty acid profile within days, and mainly influences oxidative stability of the cells.

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Section: Discussioncontrasting

confidence: 79%

“…Higher amounts of PUFA in the membrane results in a higher susceptibility to free radical attack and lipid peroxidation. This leads to a higher nutritional need for antioxidants as described in rabbits (van den Berg et al., 1991), broilers (Febel et al., 2008) and piglets (Sarkadi‐Nagy et al., 2003).…”

Section: Introductionmentioning

confidence: 99%

Dose-response effect of fish oil substitution in parturition feed on erythrocyte membrane characteristics and sow performance

Cools

Maes

Papadopoulos

et al. 2010

Journal of Animal Physiology and Animal Nutrition

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“…It is true that some animal studies have suggested that the consumption of the n-3 fatty acids may result in an elevation of reactive oxygen species (ROS), which could contribute to brain aging (Dimitrova-Sumkovska et al, 2006;Hatanaka et al, 2006;Obajimi et al, 2007). Other animal studies, however, have reported no change in ROS levels (Sarkadi-Nagy et al, 2003). Of particular importance, clinical studies have found no effect of high-dose PUFA supplementation on ROS production (Richard et al, 2008).…”

Section: Safety and Possible Side Effectsmentioning

confidence: 99%

Polyunsaturated fatty acids and epilepsy

2010

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SUMMARYOmega-3 and omega-6 polyunsaturated fatty acids (PUFAs) are dietary fatty acids that are involved in a myriad of physiologic processes in the brain. There is some evidence suggesting that PUFAs-and particularly omega-3 PUFAs-may have anticonvulsant effects, both in humans and in animals. In the present review, we assess the evidence related to the antiseizure properties of the n-3 PUFAs, discuss their possible mechanism(s) of action, and make recommendations for future clinical trials. In general, the available data from cell cultures and whole animal studies support the idea that the n-3 PUFAs have antiseizure properties. Future clinical trials involving the n-3 PUFAs should involve higher doses and longer periods of administration in order to definitively assess their possible antiseizure effects.

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“…The consumption of N-3 has been shown to result in the elevation of reactive oxygen species (ROS) [39,40]. In another study, it was documented that there was no change in ROS level after the administration of N-3 [41]. Yet, some other researchers reported that N-3 reduce lipid peroxidation, and so improve the activities of the antioxidant system [42].…”

Section: Discussionmentioning

confidence: 96%

Effects of single or combined administration of salmon calcitonin and omega-3 fatty acids vs. diclofenac sodium in sodium monoiodoacetate-induced knee osteoarthritis in male Wistar rats

Adeyemi

Olayaki

2017

Journal of Basic and Clinical Physiology and Pharmacology

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Background: There is a continuous search for a better therapy in osteoarthritis (OA) management. Therefore, this study investigated the effects of salmon calcitonin (Sct) and/or omega-3 fatty acids (N-3) relative to diclofenac sodium (DF) in induced knee osteoarthritic male Wistar rats. Methods:The 40 rats that were used in this study were divided into 8 groups (n = 5 rats), viz: Normal control; OA control; OA + N-3; OA + Low dose of Sct (Sct.Lw); OA + High dose of Sct (Sct.Hi); OA + N-3 + SCt.Lw; OA + N-3 + Sct.Hi; and, OA + DF. OA was induced with 4 mg of sodium monoiodoacetate in 40 μL of saline. The solution was injected into the left knee joint space of anaesthetised rats. Sct was administered at 2.5 and 5.0 IU/kg b.w. (im), whereas N-3 and DF were administered at 200 and 1 mg/kg b.w. (p.o.), respectively. Treatments commenced 9 days after the induction of OA, and they lasted for 28 days. Results: Sct and/or N-3 significantly reduced c-telopeptide of type 1 collagen (CTX-1), collagen type 2 α-1 (C2M), malondialdehyde (MDA), uric acid (UA), and interleukin-6 (IL-6), but, significantly increased superoxide dismutase (SOD) after OA induction. Both therapies had additive effects on C2M, MDA, SOD, and catalase (CAT), but, nonadditive actions on UA, IL-6, and CTX-1. Like the Sct and N-3, DF significantly reduced CTX-1, C2M, UA, and IL-6. However, it had no significant effect on SOD and MDA, even though it significantly reduced CAT activity. None of the therapies had significant effect on total alkaline phosphatase activity, except N-3 + Sct.Lw. Conclusions:The combined, and sometimes the single administration of Sct and N-3 proved to be better therapies in OA management than DF.

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Long chain polyunsaturate supplementation does not induce excess lipid peroxidation of piglet tissues

Abstract: The results show that dietary vitamin E effectively prevented lipid peroxidation at the LCP concentrations investigated and suggest that levels presently in infant formulas are sufficient.

Cited by 20 publications

References 15 publications

Dose-response effect of fish oil substitution in parturition feed on erythrocyte membrane characteristics and sow performance

Dose-response effect of fish oil substitution in parturition feed on erythrocyte membrane characteristics and sow performance

Polyunsaturated fatty acids and epilepsy

Effects of single or combined administration of salmon calcitonin and omega-3 fatty acids vs. diclofenac sodium in sodium monoiodoacetate-induced knee osteoarthritis in male Wistar rats

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