Long Chain Phenols. Part 41a. The Synthesis of 2‐Hydroxymethyl Derivatives of Phenols.

Abstract

Alcohols Q 0230Long Chain Phenols. Part 41a. The Synthesis of 2-Hydroxymethyl Derivatives of Phenols. -Key step of the new approach to title compounds (IV) is the regiospecific reaction of phenols (I) with paraformaldehyde (II) in the presence of SnCl4 and NBu4. Cyclic acetals [cf. (VI)] of the intermediate aldehydes are readily accessible. -(PAYNE, P.; TYMAN*, J. H. P.; MEHET, S. K.; NINAGAWA, A.; J. Chem. Res. 2006, 6, 402-405; Dep. Chem., Brunel Univ., Uxbridge, Middlesex UB8 3PH, UK; Eng.) -H. Haber 46-104