Long-chain perfluoroalkyl carboxylic acids in Pacific cods from coastal areas in northern Japan: A major source of human dietary exposure

Fujii, Yukiko; Sakurada, Tsukasa; Harada, Kouji H.; Koizumi, Akio; Kimura, Osamu; Endo, Tokiko; Haraguchi, Koichi

doi:10.1016/j.envpol.2015.01.007

Cited by 27 publications

(8 citation statements)

References 27 publications

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“…Because the collection time and geographic area are the same, dietary exposure might be the factor of difference. Interestingly, Fujii et al (, ) analyzed long chain PFCAs in fish and human serum samples, and also found correlation between long chain PFCAs in diet intake and serum PFCA levels.…”

Section: Resultssupporting

confidence: 85%

Per‐ and polyfluoroalkyl substances in Northern California cats: Temporal comparison and a possible link to cat hyperthyroidism

Wang

Guo

Gardner³

et al. 2018

Enviro Toxic and Chemistry

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The indoor environment and dietary intake are considered to be major human exposure pathways to per- and polyfluoroalkyl substances (PFASs). Cats have similar exposures to humans by sharing their residential environments, although they have different diet, body sizes, and indoor activities. In the present study, we report PFAS levels in the serum of 2 groups of Northern California cats (>10 yr old) collected during 2 time periods: 2008 to 2010 (n = 21) and 2012 to 2013 (n = 22). Levels of ∑PFAS (geometric mean) were lower in the second period (geometric mean = 8.10 ng/mL) than the first time period (geometric mean = 15.8 ng/mL), although PFAS profiles remained similar. We also analyzed PFAS levels in human serum collected in the same time period (2008-2010) and geographic area, and compared the profiles and ∑PFAS levels (15.8 vs 14.3 ng/mL for cat and human, respectively). Long chain perfluorinated carboxylic acids, especially perfluorononanoic acid and perfluoroundecanoic acid, were significantly higher in cat serum than in humans. Furthermore, serum from hyperthyroid cats in the second time period showed higher ∑PFAS level (9.50 ng/mL) compared to nonhyperthyroid cats (7.24 ng/mL), and it is the perfluorooctanoic acid levels that were statistically significantly higher in hyperthyroid cats' serum (p < 0.05). This result may indicate a possible link between PFAS levels and cat hyperthyroid, warranting a larger study for further investigation. Environ Toxicol Chem 2018;37:2523-2529. © 2018 SETAC.

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Section: Resultssupporting

confidence: 85%

Per‐ and polyfluoroalkyl substances in Northern California cats: Temporal comparison and a possible link to cat hyperthyroidism

Wang

Guo

Gardner³

et al. 2018

Enviro Toxic and Chemistry

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“…Determination of PFCAs was carried out by gas chromatography-mass spectrometry (GC-MS, Agilent 6890GC/5973inertMSD) with electron-capture negative ionization based on the method used in previous studies [ 10 , [22] , [23] , [24] ]. Briefly, 10 μL of the supernatant fraction, 0.5 ng of 13 C 2 -labeled PFHxA, 13 C 4 -labeled PFOA, 13 C 5 -labeled PFNA, 13 C 2 -labeled PFDA, 13 C 2 -labeled PFUnDA and 13 C 2 -labeled PFDoDA were added to a vial and dried.…”

Section: Methodsmentioning

confidence: 99%

Effects of perfluoroalkyl carboxylic acids on the uptake of sulfobromophthalein via organic anion transporting polypeptides in human intestinal Caco-2 cells

Kimura

Fujii

Haraguchi

et al. 2020

Biochemistry and Biophysics Reports

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We performed a detailed investigation of the uptake of sulfobromophthalein (BSP) from the apical membrane of Caco-2 cells, which is a substrate for organic anion transporting polypeptides (OATPs), and calculated the kinetic parameters of BSP uptake as follows: K m = 13.9 ± 1.3 μM, V max = 1.15 ± 0.07 nmol (mg protein) −1 (5 min) −1 , and k d = 38.2 ± 0.53 μL (mg protein) −1 (5 min) −1 . Coincubation with medium-chain (C7–C11) perfluoroalkyl carboxylic acids (PFCAs), such as perfluoroheptanoic acid (PFHpA, C7), perfluorooctanoic acid (PFOA, C8), perfluorononanoic acid (PFNA, C9), perfluorodecanoic acid (PFDA, C10) and perfluoroundecanoic acid (PFUnDA, C11), significantly decreased BSP uptake by 27–55%, while coincubation with short- (C3–C6) and long-chain (C12–C14) PFCAs decreased the uptake only slightly. Dixon plotting suggested that PFOA, PFNA and PFDA competitively inhibited the BSP uptake with inhibition constant (K i ) values of 62.2 ± 1.3 μM, 35.3 ± 0.1 μM and 43.2 ± 0.3 μM, respectively. PFCAs with medium-chains could be substrates for OATPs, probably OATP2B1, which is the most abundantly expressed OATP isoform in Caco-2 cells.

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“…In the top predato lake trout ( Salvelinus namaycush ) of the Great Lakes, the main PFAS observed was PFOS at concentrations as high as 121 ± 14 ng/g (Furdui et al, 2007), and PFOA (0.65– 5.5 ng/L) (De Silva et al, 2011). Although the general population is exposed to low levels of PFAS from various sources such as food and consumer products, individuals can be exposed to higher levels near contaminated sites by consuming contaminated food or polluted drinking water (Fujii et al, 2015; Post et al, 2012). Certain PFAS, notably PFOS and long-chain perfluoroalkyl carboxylates (PFCAs), such as perfluoroundecanoic acid (PFUnA; C11), can accumulate in tissues (Labadie and Chevreuil, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…While the general population is exposed to low levels of PFAS from various sources such as food packaging and consumer products, individuals can be exposed to higher levels due to the consumption of contaminated food or drinking water (Fujii et al, 2015; Post et al, 2012). Numerous studies have also reported the presence of PFAS in the environment and wildlife (Barbo et al, 2023; Evich et al, 2022; Fair et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

PFAS assessment in fish – samples from Illinois waters

Sands,

Zhang,

Jensen

et al. 2023

Preprint

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Per- and Polyfluoroalkyl substances (PFAS) have been widely used in pesticide production, electroplating chemical industry, packaging, paper making, clean energy materials, and other industries. This study documented fish tissues in four target water bodies (16 sampling points) in Illinois collected during 2021-22. Concentrations of 17 PFASs were determined in nine fish species collected from four waterways/aquatic systems in the northwest corner of Illinois for the assessment of potential health risks. At least four PFAS (PFHxA, PFHxS, PFOS, and PFBS) were detected at each site. Across all waterbodies and sampling locations, the mean of the total (∑) PFAS levels varied from 7.32 to 335.05 ng/g wet weight (ww) in 2021 and from 13.19 to 146.13 ng/g wet weight (ww) in 2022. In individual fish fillet, the total PFAS ranged from 6.76 to 191.21 ng/g ww in 2021 samples and 1.39 ng/g ww to 37.50 ng/g ww in 2022 samples. The most abundant compound in each species was PFOS in 2021 and PFHxA in 2022, which accounted for 21.25 to 77.53% of the total PFASs. On an average, levels of PFOS in almost all fish were high enough to trig-ger fish consumption recommendations. More research is needed to further assess the sources and accumulation of PFAS in aquatics and the potential risk to the environment.

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Long-chain perfluoroalkyl carboxylic acids in Pacific cods from coastal areas in northern Japan: A major source of human dietary exposure

Cited by 27 publications

References 27 publications

Per‐ and polyfluoroalkyl substances in Northern California cats: Temporal comparison and a possible link to cat hyperthyroidism

Per‐ and polyfluoroalkyl substances in Northern California cats: Temporal comparison and a possible link to cat hyperthyroidism

Effects of perfluoroalkyl carboxylic acids on the uptake of sulfobromophthalein via organic anion transporting polypeptides in human intestinal Caco-2 cells

PFAS assessment in fish – samples from Illinois waters

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