Long chain alkyl and fluoroalkyl glucose and glucosamine derivatives as hyaluronic acid subunits—Scaffolds for drug delivery

Koroniak-Szejn, Katarzyna; Tomaszewska, Joanna; Grajewski, Jakub; Koroniak, Henryk

doi:10.1016/j.jfluchem.2019.01.004

Cited by 10 publications

(1 citation statement)

References 23 publications

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“…HA is a system susceptible to chemical modifications, which enables adapting its properties to pharmaceutical applications. One of the strategies involves the introduction of long fluorinated aliphatic chains to increase the lipophilicity of the system and, thus, more efficient transport across cell membranes [ 115 ]. Moreover, HA can be a precursor for preparing other DDS—porous calcium carbonate [ 116 ].…”

Section: Other Polysaccharidesmentioning

confidence: 99%

Recent Reports on Polysaccharide-Based Materials for Drug Delivery

Kurczewska

2022

Polymers

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Polysaccharides constitute one of the most important families of biopolymers. Natural polysaccharide-based drug delivery systems are of constant interest to the scientific community due to their unique properties: biocompatibility, non-toxicity, biodegradability, and high availability. These promising biomaterials protect sensitive active agents and provide their controlled release in targeted sites. The application of natural polysaccharides as drug delivery systems is also intensively developed by Polish scientists. The present review focuses on case studies from the last few years authored or co-authored by research centers in Poland. A particular emphasis was placed on the diversity of the formulations in terms of the active substance carried, the drug delivery route, the composition of the material, and its preparation method.

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Section: Other Polysaccharidesmentioning

confidence: 99%

Recent Reports on Polysaccharide-Based Materials for Drug Delivery

Kurczewska

2022

Polymers

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A New Efficient One‐Pot Three‐Component Synthesis of Diverse Pyrido[1,2‐a]pyrimidines

Goryaeva,

Kushch,

Surnina

et al. 2023

ChemistrySelect

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The pyrido[1,2‐a]pyrimidine scaffold has great potential for the creation of bioactive substances. Here we propose a simple, cost‐effective, efficient approach to forming this core based on a one‐pot three‐component reaction of commercially available 3‐oxo esters, α,β‐unsaturated aldehydes and 1,3‐diaminopropane. The developed strategy makes it possible to obtain diverse pyrido[1,2‐a]pyrimidines thanks to alternative intramolecular cyclization pathways that depend on the substituent in the 3‐oxo ester. Their diastereomeric structure was determined using NMR spectroscopy and XRD. A mechanism for the formation of new pyrido[1,2‐a]pyridines has been proposed.

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