Long-Chain Acyl-CoA Synthetase is Associated with the Growth of Malassezia spp.

Tenagy,; Tejima, Kengo; Chen, Xinyue; Iwatani, Shun; Kajiwara, Susumu

doi:10.3390/jof5040088

Cited by 11 publications

(14 citation statements)

References 32 publications

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“…Long-chain fatty acyl-CoA synthetase 1 (FAA1) recognizes and facilitates uptake of C 14 -C 16 fatty acids important for Malassezia growth. 67,68 PLAA in turn positively regulates cytosolic and calcium-independent phospholipase A2 activities. Phospholipases are a heterogenous group of enzymes that hydrolyse ester linkages in phospholipids by cleaving specific ester bonds.…”

Section: Discussionmentioning

confidence: 99%

“…[81][82][83] The enriched lipids are within the spectrum of fatty acids that are preferentially utilised by Malassezia (C12-C20). 84,85 Due to the lack of fatty acid synthetases, Malassezia depends on the assimilation of fatty acids from the host by means of lipases, phospholipases, and sphingomyelinases.…”

Section: Discussionmentioning

confidence: 99%

“…Importantly, we found enhanced metabolic activity of the fungus in AD-like skin that was manifested by altered gene expression compared to control skin. Notably, MpFAA1, a key fungal gene implicated in fatty acid uptake, activation and consequently in fungal growth, 67,68 was upregulated in the ADlike skin (Fig. 7H).…”

Section: Changes In Lipid Metabolism In Ad-like Skin Support Malassez...mentioning

confidence: 98%

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Epidermal barrier dysregulation in atopic skin predisposes for excessive growth of the allergy-associated yeastMalassezia

Ruchti,

Zwicky,

Becher

et al. 2023

Preprint

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The skin barrier is vital for protection against environmental threats including insults caused by skin-resident microbes. Dysregulation of the barrier is a hallmark of atopic dermatitis (AD) and ichthyosis, with variable consequences for host immune control of colonizing commensals and opportunistic pathogens. While sensitisation toMalassezia, the most abundant commensal fungus of the skin, is common in AD, its relevance for pathogenesis remains unclear. Here we show that in barrier-disrupted skin,Malasseziaacquires enhanced fitness. This is not a consequence of the dysregulated allergic immune status characteristic for AD but is rather explained by structural and metabolic changes in the cutaneous niche that provide increased accessibility and a favourable lipid profile, to which the lipid-dependent yeast adapts for enhanced nutrient assimilation. These findings reveal fundamental insights into the role of the mycobiota in the pathogenesis of common skin barrier disorders.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Changes In Lipid Metabolism In Ad-like Skin Support Malassez...mentioning

confidence: 98%

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Epidermal barrier dysregulation in atopic skin predisposes for excessive growth of the allergy-associated yeastMalassezia

Ruchti,

Zwicky,

Becher

et al. 2023

Preprint

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“…On a secondary alcohol degradation gene cluster, sadC is involved in the degradation of secondary alcohol; sadD, sadA, and sadB encode a BVMO, and two esterases catalyze secondary alcohol to the corresponding primary alcohols [ 34 ]. In the end, acyl-CoA synthetase encoded by FAT1 and FAA1 catalyzes fatty acid to enter the TCA cycle [ 35 ].…”

Section: Biodegradation Pathways and Related Genesmentioning

confidence: 99%

Bioengineering for the Microbial Degradation of Petroleum Hydrocarbon Contaminants

2023

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Petroleum hydrocarbons are relatively recalcitrant compounds, and as contaminants, they are one of the most serious environmental problems. n-Alkanes are important constituents of petroleum hydrocarbons. Advances in synthetic biology and metabolic engineering strategies have made n-alkane biodegradation more designable and maneuverable for solving environmental pollution problems. In the microbial degradation of n-alkanes, more and more degradation pathways, related genes, microbes, and alkane hydroxylases have been discovered, which provide a theoretical basis for the further construction of degrading strains and microbial communities. In this review, the current advances in the microbial degradation of n-alkanes under aerobic condition are summarized in four aspects, including the biodegradation pathways and related genes, alkane hydroxylases, engineered microbial chassis, and microbial community. Especially, the microbial communities of “Alkane-degrader and Alkane-degrader” and “Alkane-degrader and Helper” provide new ideas for the degradation of petroleum hydrocarbons. Surfactant producers and nitrogen providers as a “Helper” are discussed in depth. This review will be helpful to further achieve bioremediation of oil-polluted environments rapidly.

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“…Pityriasis versicolor (PV) also known as tinea versicolor is caused by basidiomycetous yeasts of the genus Malassezia , characterized by lipid-dependent growth [ 1 – 3 ] and narrow specialization in the context of occupied ecological niches [ 2 ]. With respect to human skin, species of the genus Malassezia may have positive as well as negative health impact [ 4 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

A case of anti- pityriasis versicolor therapy that preserves healthy mycobiome

et al. 2020

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Background The impact of Malassezia yeasts on skin mycobiome and health has received considerable attention recently. Pityriasis versicolor (PV), a common dermatosis caused by Malassezia genus worldwide, is a manifestation of dysbiosis. PV can be associated with hyper- and/or hypopigmented skin lesions. This disease entity is characterized by high percentage of relapses, which demands a proper antifungal therapy that is based on unambiguous species identification and drug susceptibility testing. Case presentation Comprehensive analysis of PV case in man presenting simultaneously hyper- and hypopigmented skin lesions was performed. Conventional and molecular diagnostic procedures revealed Malassezia furfur and Malassezia sympodialis, respectively as etiological agents of skin lesions observed. Susceptibility tests showed significantly lowered sensitivity of M. furfur cells to fluconazole. Based on susceptibility profiles local antifungal therapy with drugs characterized by entirely different mechanism of action was included. Conclusions Our study indicates that cases of PV represented by two types of skin lesions in one patient may be associated with distinct Malassezia species. Moreover, as observed in this case, each of the isolated etiological agents of PV may differ significantly in susceptibility to antifungals. This can significantly complicate the treatment of dermatosis, which by definition is associated with a significant percentage of relapses. In the presented case localized topical treatment was sufficient and successful while allowing maintaining the physiological mycobiome.

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Long-Chain Acyl-CoA Synthetase is Associated with the Growth of Malassezia spp.

Cited by 11 publications

References 32 publications

Epidermal barrier dysregulation in atopic skin predisposes for excessive growth of the allergy-associated yeastMalassezia

Epidermal barrier dysregulation in atopic skin predisposes for excessive growth of the allergy-associated yeastMalassezia

Bioengineering for the Microbial Degradation of Petroleum Hydrocarbon Contaminants

A case of anti- pityriasis versicolor therapy that preserves healthy mycobiome

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